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Scientists at NTU Singapore and KAIST uncover a new mechanism that causes Parkinson’s disease
The lead author, Dr Jeongjin Kim said, “The therapeutic implications of this study for the treatment of Parkinsonian symptoms are profound. It may soon become possible to remedy movement disorders without using L-DOPA, a pre-cursor to dopamine.” http://bit.ly/2xdI7qV
The lead author, Dr Jeongjin Kim said, “The therapeutic implications of this study for the treatment of Parkinsonian symptoms are profound. It may soon become possible to remedy movement disorders without using L-DOPA, a pre-cursor to dopamine.” http://bit.ly/2xdI7qV
stepan13
in
Cure Parkinson's
7 years ago
Anxiety in PD
My husband has had PD for 7 years. He is experiencing high anxiety. I understand that some anti anxiety medication interferes with dopamine. How is anxiety treated in patients with Parkinson's? What is an effective medication?
My husband has had PD for 7 years. He is experiencing high anxiety. I understand that some anti anxiety medication interferes with dopamine. How is anxiety treated in patients with Parkinson's? What is an effective medication?
leojohn
in
Cure Parkinson's
7 years ago
Dopamine agonists
Hi all, does anyone have any success stories on using DA's? I'm sure my Neuro is going to try and steer me this way soon but I'm wary having heard of so many bad experiences. Thanks.
Hi all, does anyone have any success stories on using DA's? I'm sure my Neuro is going to try and steer me this way soon but I'm wary having heard of so many bad experiences. Thanks.
seamus60680
in
Cure Parkinson's
7 years ago
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GET YOUR KNITTING NEEDLES OUT TO HELP ALLEVIATE PAIN...
Stitchlinks is the home for therapeutic knitting since 2005, it is a pioneering an exciting approach to healthcare which could have global implications and a massive, positive impact on your well-being. It is at the core of groundbreaking research, and a movement which utilises crafts, in particular,
Stitchlinks is the home for therapeutic knitting since 2005, it is a pioneering an exciting approach to healthcare which could have global implications and a massive, positive impact on your well-being. It is at the core of groundbreaking research, and a movement which utilises crafts, in particular,
Barmac5
in
Fibromyalgia Action UK
7 years ago
Controlling augmentation and impulse control issues
Ok I have no personal experience of this but as there are many on here going through the horrors of augmentation I thought I would pass on the experience of a poster on another rls forum. He was prescribed naltrexone for a separate issue but found that after he started naltrexone he was able to half
Ok I have no personal experience of this but as there are many on here going through the horrors of augmentation I thought I would pass on the experience of a poster on another rls forum. He was prescribed naltrexone for a separate issue but found that after he started naltrexone he was able to half
involuntarydancer
in
Restless Legs Syndrome
7 years ago
Help with research... identifying the cause of orthostatic hypotension & autonomic dysfunction
I know there are a select number of decent researchers on this site.... those who read their fair share of medical papers and journal publications. I need some help with research...I simply don't have time to read everything on my own. The problem I'm interested in needs to be tackled because it very
I know there are a select number of decent researchers on this site.... those who read their fair share of medical papers and journal publications. I need some help with research...I simply don't have time to read everything on my own. The problem I'm interested in needs to be tackled because it very
hopeful88
in
Cure Parkinson's
7 years ago
can we provide Soda or soft drinks to Parkinson patients
My father is suffering from ParkinsonD from last 10 - 12 yrs , presently he is taken approx. 700mg of levodopa & carbidopa. some time he behave normal after taken a medicine and some time not. when I saw a report on soft drink, on that report, on that report say soda or cold drinks release a dopamine
My father is suffering from ParkinsonD from last 10 - 12 yrs , presently he is taken approx. 700mg of levodopa & carbidopa. some time he behave normal after taken a medicine and some time not. when I saw a report on soft drink, on that report, on that report say soda or cold drinks release a dopamine
rishiraj09
in
Cure Parkinson's
7 years ago
Premotor Symptoms of Parkinson’s Disease - EHP 2013
Developing methods for researching Premotor symptoms in PD seems so very important. Here's an excerpt from a well-focused review. Research on the Premotor Symptoms of Parkinson’s Disease: Clinical and Etiological Implications Environ Health Perspect 2013 Nov-Dec; 121(11
Developing methods for researching Premotor symptoms in PD seems so very important. Here's an excerpt from a well-focused review. Research on the Premotor Symptoms of Parkinson’s Disease: Clinical and Etiological Implications Environ Health Perspect 2013 Nov-Dec; 121(11
aspergerian
in
Cure Parkinson's
7 years ago
Has anyone else tried GABA?
I am bringing this up for discussion and as a recommendation. Since RLS people have a shortage of GABA in their brains and an excess of glutamate, it helps to understand what these substances are and do. They are both neurotransmitters your body produces (one from the other) and while glutamate is
I am bringing this up for discussion and as a recommendation. Since RLS people have a shortage of GABA in their brains and an excess of glutamate, it helps to understand what these substances are and do. They are both neurotransmitters your body produces (one from the other) and while glutamate is
lauraflora
in
Restless Legs Syndrome
7 years ago
9 days & nights with no RLS or withdrawal symptoms--ahh!
After suffering through over a month of DAWS or Dopamine Agonist Withdrawal Syndrome when I went cold turkey off Ropinerole, I transitioned into Lyrica. It has been 9, no now 10 wonderful days -- I feel like a normal person again. No RLS symptoms at all!!! I'm taking 100 mgs 3x/day. Going cold turkey
After suffering through over a month of DAWS or Dopamine Agonist Withdrawal Syndrome when I went cold turkey off Ropinerole, I transitioned into Lyrica. It has been 9, no now 10 wonderful days -- I feel like a normal person again. No RLS symptoms at all!!! I'm taking 100 mgs 3x/day. Going cold turkey
Bganim1947
in
Restless Legs Syndrome
7 years ago
Phase 1b clinical trial of gene therapy (by Voyager) has impressive success
A year ago, Roy Prop alerted us all to the clinical trial of Voyager Therapeutics. https://www.technologyreview.com/s/602193/manufacturing-dopamine-in-the-brain-with-gene-therapy/ Instead of kicking a dying horse, the Substantia Nigra, Voyager had the daring, clever idea of working with a nearby brain
A year ago, Roy Prop alerted us all to the clinical trial of Voyager Therapeutics. https://www.technologyreview.com/s/602193/manufacturing-dopamine-in-the-brain-with-gene-therapy/ Instead of kicking a dying horse, the Substantia Nigra, Voyager had the daring, clever idea of working with a nearby brain
lempa_nik
in
Cure Parkinson's
7 years ago
So yesterday I went to see my neurologist and ......
By 2.30 he was running 1hr late. So I sat in the waiting area and thought " why the hell am I here". Everyone else needed his help . I was just adding to his backlog. I wanted advice on reducing 6mg Rotigotine patches . (I reasonably believe that my exercise routine including running
By 2.30 he was running 1hr late. So I sat in the waiting area and thought " why the hell am I here". Everyone else needed his help . I was just adding to his backlog. I wanted advice on reducing 6mg Rotigotine patches . (I reasonably believe that my exercise routine including running
Mike1942
in
Cure Parkinson's
7 years ago
Insomnia is the game.
Morning everyone I have had a DX of PD for 3yrs + now. This post will be timed about 0330. So you see my problem. But I am a fitness freak. To increase my own Dopamine I run. 5 ,km Park runs every Saturday. Plus other extreme exercise all week. I have a personal trainer and physio who repairs the
Morning everyone I have had a DX of PD for 3yrs + now. This post will be timed about 0330. So you see my problem. But I am a fitness freak. To increase my own Dopamine I run. 5 ,km Park runs every Saturday. Plus other extreme exercise all week. I have a personal trainer and physio who repairs the
Mike1942
in
Cure Parkinson's
7 years ago
AGM 2017
I attended the 2017 AGM in London yesterday and learnt about Isometric exercise. I learnt how it increases muscle mass and as a consequence, Dopamine amounts. The exercises demonstrated targeted thigh and calf muscles. As always, I developed RLS last night and therefore used these exercises. Weather
I attended the 2017 AGM in London yesterday and learnt about Isometric exercise. I learnt how it increases muscle mass and as a consequence, Dopamine amounts. The exercises demonstrated targeted thigh and calf muscles. As always, I developed RLS last night and therefore used these exercises. Weather
tmbg05857
in
Restless Legs Syndrome
7 years ago
YOUR INPUT
https://youtu.be/C3xM8sHGoiQ I have come to the conclusion that you will not be able to use symptoms to category Parkinson.s. The next step would be to categorize medications and are they helping your symptoms. You should be diagnosed for at least 3-4 years and there should also be the question are you
https://youtu.be/C3xM8sHGoiQ I have come to the conclusion that you will not be able to use symptoms to category Parkinson.s. The next step would be to categorize medications and are they helping your symptoms. You should be diagnosed for at least 3-4 years and there should also be the question are you
Serenity_finaly-1
in
Cure Parkinson's
7 years ago
Champix…The choice..!!
Seeing a lot of Champix quitters on the forum and being one myself I would like to explain what I have learned with the use of Champix: "Everything is a choice" (Anonymous). We can escape from the tyranny of our bad habits using any method that works. We have free will. The upside down mornings or
Seeing a lot of Champix quitters on the forum and being one myself I would like to explain what I have learned with the use of Champix: "Everything is a choice" (Anonymous). We can escape from the tyranny of our bad habits using any method that works. We have free will. The upside down mornings or
Hercu
Valued Contributor
in
No Smoking Day
7 years ago
Terminal density, terminal arbor size
Does anyone understand these terms and the likes of them and what their relevance to RLS might be? Here's three medical papers with such terms: "Effects of long-term treatment with dopamine receptor agonists and antagonists on terminal arbor size." https://www.ncbi.nlm.nih.gov/pubmed/12372014 "D2 Dopamine
Does anyone understand these terms and the likes of them and what their relevance to RLS might be? Here's three medical papers with such terms: "Effects of long-term treatment with dopamine receptor agonists and antagonists on terminal arbor size." https://www.ncbi.nlm.nih.gov/pubmed/12372014 "D2 Dopamine
ironbrain
in
Restless Legs Syndrome
7 years ago
Recently diagnosed with Parkinson's syndrome.
I had Dte In 2016 I fell backwards and hit my head on my street pretty hard. It was hard enough to cause u huge lump on the ack of my head. I also had passed out. I went to the ER, where they did an MRI and a CAT scan they found nothing. But now a little over a year I have had my left arm jerking
I had Dte In 2016 I fell backwards and hit my head on my street pretty hard. It was hard enough to cause u huge lump on the ack of my head. I also had passed out. I went to the ER, where they did an MRI and a CAT scan they found nothing. But now a little over a year I have had my left arm jerking
Hidden
in
Cure Parkinson's
7 years ago
A second medication
Hi everyone. I'm after a bit of advice. I'm looking for something I can take for RLS a couple of times a week that it not an opiate. I already take codeine but can't take it every day due to tolerance build up-it just doesn't work when I do that.I don't want to take a dopamine agonist for fear of augmentation
Hi everyone. I'm after a bit of advice. I'm looking for something I can take for RLS a couple of times a week that it not an opiate. I already take codeine but can't take it every day due to tolerance build up-it just doesn't work when I do that.I don't want to take a dopamine agonist for fear of augmentation
Jumpey
in
Restless Legs Syndrome
7 years ago
Augmentation, opiates, benzodiazepines
I read a lot on here about the danger of augmentation with dopamine agonists and of switching to opiates. But from what I read, opiates are also dopamine agonists. My doc is probably about as keen to let me have opiates or even benzodiazepines as offer an alcohol a drink. I, myself, have thought occasionally
I read a lot on here about the danger of augmentation with dopamine agonists and of switching to opiates. But from what I read, opiates are also dopamine agonists. My doc is probably about as keen to let me have opiates or even benzodiazepines as offer an alcohol a drink. I, myself, have thought occasionally
ironbrain
in
Restless Legs Syndrome
7 years ago
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