I am bringing this up for discussion and as a recommendation. Since RLS people have a shortage of GABA in their brains and an excess of glutamate, it helps to understand what these substances are and do. They are both neurotransmitters your body produces (one from the other) and while glutamate is Excitatory, Gaba is Inhibitory.
That means glutamate causes over-excitability to the nerves, etc., while GABA is calming and turns off that excitability.
I know here and there I have read that RLS people should not take GABA since it MAY turn back into glutamate. HOWEVER, I decided some time ago (back in early June) upon recommendation of Julia Ross's excellent book The Mood Cure, to take some GABA, along with some of the other things she recommends. I had to play around with dosage for a few days, when I took it, and what form seemed to work the best. BUT, if I left it out, trouble started again, so I have been taking it rather consistently since then.
I did not realize until recently quite how important it was. I now consider it one of the best of the amino acids recommended, for stopping/greatly lessening RLS and helping so much with sleep. I never have had any problem with it causing RLS ( by presumably turning back into glutamate.)
So, I am recommending to anyone out there to give it a try. I have used Solgar GABA 500 mg, and (this one I REALLY find effective)Source Naturals GABA CALM. It has a few other things in it, but the beauty of it is that it is sublingual (under your tongue,) so it gets into your system fast, as well as by-passes your digestive system (some things are better that way.) It is great before bed and in the middle of the night.
And, I will mention this also. Yes, I take an assortment of other things. This is because RLS has several causes (iron, folate, GABA, Dopamine deficiencies by problems with absorption or not crossing the blood/brain barrier). And stress (over- active adrenals) can make the problem worse. Plus food and environmental triggers. And spinal mis-alignment. So one does not always know which cause or body system or trigger is acting up at any one time. So I have an arsenal of things to address it. Sometimes it might be one thing, sometimes another.
BUT, I will say again that GABA is one of the best. At least for me. We are all different and what may work for me, may not work for someone else. But, I suggest giving it a try.