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PCPs take note
As I've just joined, let me say that I hope that general practitioners are aware of this website. In my experience, their understanding of how to treat RLS is minimal and leads to patients experiencing severe disease symptoms due to augmentation. My experience may be one of many more. I hope to share
As I've just joined, let me say that I hope that general practitioners are aware of this website. In my experience, their understanding of how to treat RLS is minimal and leads to patients experiencing severe disease symptoms due to augmentation. My experience may be one of many more. I hope to share
Perhapslove
in
Restless Legs Syndrome
1 year ago
Prolactin
I have been meaning to tackle prolactin (PRL) for at least a dozen years, but there are hundreds of PCa papers and who has the time? It's an important topic that is rarely mentioned. A recent paper (Jan 13, 2003 - my 75th birthday, so how could I ignore it?) has this in the intro (note - PRLR is the
I have been meaning to tackle prolactin (PRL) for at least a dozen years, but there are hundreds of PCa papers and who has the time? It's an important topic that is rarely mentioned. A recent paper (Jan 13, 2003 - my 75th birthday, so how could I ignore it?) has this in the intro (note - PRLR is the
pjoshea13
in
Fight Prostate Cancer
1 year ago
NURR1: Facilitating the transition of neural stem cells into functional dopaminergic neurons.
//////What is NURR1? Nuclear receptor related 1 protein (Nurr1) is an important transcription factor required for differentiation and maintenance of midbrain dopaminergic (DA) neurons. Since decrease in Nurr1 function either due to diminished expression or rare mutation is associated with Parkinson's
//////What is NURR1? Nuclear receptor related 1 protein (Nurr1) is an important transcription factor required for differentiation and maintenance of midbrain dopaminergic (DA) neurons. Since decrease in Nurr1 function either due to diminished expression or rare mutation is associated with Parkinson's
House2
in
Cure Parkinson's
1 year ago
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Gender Differences in Levodopa Pharmacokinetics in Levodopa-Naïve Patients With Parkinson’s Disease
The differences in plasma LD concentrations between men and women over time. Original research article Front. Med., 31 May 2022
https://www.frontiersin.org/articles/10.3389/fmed.2022.909936/full
On my search for the Pharmacokinetics, pharmacodynamics of the various C/L medications, I came
The differences in plasma LD concentrations between men and women over time. Original research article Front. Med., 31 May 2022
https://www.frontiersin.org/articles/10.3389/fmed.2022.909936/full
On my search for the Pharmacokinetics, pharmacodynamics of the various C/L medications, I came
Esperanto
in
Cure Parkinson's
1 year ago
MANF Stack Rationale
….FOR INFORMATIONAL PURPOSES ONLY…… Unconventional neurotrophic factor MANF targets midbrain structures, including the Substantia Nigra, through endoplasmic reticulum mediated mechanisms. The midbrain, also called the mesencephalon, region of the brain serves important functions in motor activity
….FOR INFORMATIONAL PURPOSES ONLY…… Unconventional neurotrophic factor MANF targets midbrain structures, including the Substantia Nigra, through endoplasmic reticulum mediated mechanisms. The midbrain, also called the mesencephalon, region of the brain serves important functions in motor activity
House2
in
Cure Parkinson's
1 year ago
Does anyone else suffer from these RLS symptoms? - Need Help, all comments appreciated
Hello, my name is Justin and I have been diagnosed with RLS for about a week now, but I have been suffering from SEVERE insomnia for about 7 weeks now, ever since I had a surgery. Most people that I read about on here, comment about how they have pain in their feet/legs which is why they have their
Hello, my name is Justin and I have been diagnosed with RLS for about a week now, but I have been suffering from SEVERE insomnia for about 7 weeks now, ever since I had a surgery. Most people that I read about on here, comment about how they have pain in their feet/legs which is why they have their
jdawg77
in
Restless Legs Syndrome
1 year ago
Most effective medications for suppressing Periodic Limb Movements of Sleep (PLMS)
An interesting article from the Journal of Clinical Sleep Medicine (Jan 24, 2023) https://doi.org/10.5664/jcsm.10440 I'm unable to access the full article but here's part of the abstract. STUDY OBJECTIVES:Periodic limb movements during sleep (PLMS) are a frequent finding in restless legs syndrome (
An interesting article from the Journal of Clinical Sleep Medicine (Jan 24, 2023) https://doi.org/10.5664/jcsm.10440 I'm unable to access the full article but here's part of the abstract. STUDY OBJECTIVES:Periodic limb movements during sleep (PLMS) are a frequent finding in restless legs syndrome (
Hidden
in
Restless Legs Syndrome
1 year ago
St. John’s wort, ursolic acid, Gardenia jasminoides
Hubby has been having a bad patch lately with symptoms deteriorating so we decided to try increasing his madopar from 3 1/2 x 50/12.5 tablets to 5 but he couldn’t tolerate the extra (usual extra rigidity and suicidal thinking) so reduced back to 4 1/2. PD nurse still thinks it isn’t enough. Maybe with
Hubby has been having a bad patch lately with symptoms deteriorating so we decided to try increasing his madopar from 3 1/2 x 50/12.5 tablets to 5 but he couldn’t tolerate the extra (usual extra rigidity and suicidal thinking) so reduced back to 4 1/2. PD nurse still thinks it isn’t enough. Maybe with
LAJ12345
in
Cure Parkinson's
1 year ago
Levodopa May Reduce Neuroinflammation
This intrigues me. Summary: Levodopa, a drug commonly prescribed for the treatment of Parkinson’s disease that increases dopamine in the brain was found to reverse the effects of neuroinflammation on the reward system and improve symptoms associated with depression. https://neurosciencenews.com/levodopa-inflammation-depression
This intrigues me. Summary: Levodopa, a drug commonly prescribed for the treatment of Parkinson’s disease that increases dopamine in the brain was found to reverse the effects of neuroinflammation on the reward system and improve symptoms associated with depression. https://neurosciencenews.com/levodopa-inflammation-depression
jimcaster
in
Cure Parkinson's
1 year ago
Neck and arm twitches at night leading to arm and leg spasms. Any treatment options?
I have not been sleeping much as recently I have muscle twitches in my neck. These occur every 15-20 seconds, on my left side and lead to a reflexive head or leg spasm. I have also been having these twitches in my left arm for months, leading to sleeping on my left side being very difficult. I have figured
I have not been sleeping much as recently I have muscle twitches in my neck. These occur every 15-20 seconds, on my left side and lead to a reflexive head or leg spasm. I have also been having these twitches in my left arm for months, leading to sleeping on my left side being very difficult. I have figured
Swimfast
in
Cure Parkinson's
1 year ago
blood sugar levels
I read that levodopa carbadopa increases your blood level of glucose does anyone take any non-dopamine therapy that works when I take levadopa I can’t stand up. And all of my te tendons, get weak and burn. I also have Lyme disease I’ll read that to her and dopamine enhance Lyme disease.
I read that levodopa carbadopa increases your blood level of glucose does anyone take any non-dopamine therapy that works when I take levadopa I can’t stand up. And all of my te tendons, get weak and burn. I also have Lyme disease I’ll read that to her and dopamine enhance Lyme disease.
Marcia123
in
Cure Parkinson's
1 year ago
NURR1
NURR1 and its transcriptional targets are downregulated in midbrain dopamine neurons that express high levels of the disease-causing protein α-synuclein, as observed in rodent models and patients with Parkinson diseaseα-Synuclein overexpression results in an almost complete blockade of GDNF trophic signalling
NURR1 and its transcriptional targets are downregulated in midbrain dopamine neurons that express high levels of the disease-causing protein α-synuclein, as observed in rodent models and patients with Parkinson diseaseα-Synuclein overexpression results in an almost complete blockade of GDNF trophic signalling
Little_apple
in
Cure Parkinson's
1 year ago
what do you do when you’re “off”
I have three main “off” symptoms. Tight left leg, left foot dystonia, and anxiety. Someone recently told me that dopamine breaks down to noradrenaline and then to adrenaline, which can feel anxiety especially when movement is difficult. My tendency is to want to sit still until this passes, which can
I have three main “off” symptoms. Tight left leg, left foot dystonia, and anxiety. Someone recently told me that dopamine breaks down to noradrenaline and then to adrenaline, which can feel anxiety especially when movement is difficult. My tendency is to want to sit still until this passes, which can
rebtar
in
Cure Parkinson's
1 year ago
Linking what we eat, with depression and brain conditions
Saw an article written in September last year on the site : The best brain possible. This article links diet to depression via the gut - and the 'brain around the gut'. That I thought was interesting. There are dietary tips to pick up from here - and additional information about dopamine and serotonin
Saw an article written in September last year on the site : The best brain possible. This article links diet to depression via the gut - and the 'brain around the gut'. That I thought was interesting. There are dietary tips to pick up from here - and additional information about dopamine and serotonin
Writeronstack
in
Headway
1 year ago
How do you approach managing your ADHD?
After being diagnosed a little over two months ago, and trying to figure out how to manage it, I've come up with how I'm approaching this and am curious how others have approached this? Maybe what's worked for you and what hasn't. I know we're all different so there's no "one size fits all" approach
After being diagnosed a little over two months ago, and trying to figure out how to manage it, I've come up with how I'm approaching this and am curious how others have approached this? Maybe what's worked for you and what hasn't. I know we're all different so there's no "one size fits all" approach
Old_Owl
in
CHADD's Adult ADHD Support
1 year ago
Morphine not working on RLS? Any experience?
Does anyone have any experience of morphine in the treatment of RLS? I have had to come off Buprenorphine, which did help with the RLS, but turned me into a complete zombie (extreme tiredness and depression, amongst other things). I’m now on morphine, and while it seems to make a little bit sleepy to
Does anyone have any experience of morphine in the treatment of RLS? I have had to come off Buprenorphine, which did help with the RLS, but turned me into a complete zombie (extreme tiredness and depression, amongst other things). I’m now on morphine, and while it seems to make a little bit sleepy to
Typicallygaslit
in
Restless Legs Syndrome
1 year ago
Getting ready to try a neurogenesis protocol.
I think I've got the neuroprotection and neurorehab down pretty well. Next up, neurogenesis... Until recently, neuroscientists believed that the central nervous system, including the brain, was incapable of neurogenesis and unable to regenerate. However, stem cells were discovered in parts of the adult
I think I've got the neuroprotection and neurorehab down pretty well. Next up, neurogenesis... Until recently, neuroscientists believed that the central nervous system, including the brain, was incapable of neurogenesis and unable to regenerate. However, stem cells were discovered in parts of the adult
House2
in
Cure Parkinson's
1 year ago
Post DAWS: Pregabalin Augmentation
Hi, All. I found a couple of older threads started by Joolsg inviting comments on some studies that suggested that the risk of augmentation was lower for pregabalin than it was for the dopamine agonists. Given their age--and since there is a slight twist to my story--I've enlarged the Subject to include
Hi, All. I found a couple of older threads started by Joolsg inviting comments on some studies that suggested that the risk of augmentation was lower for pregabalin than it was for the dopamine agonists. Given their age--and since there is a slight twist to my story--I've enlarged the Subject to include
Hidden
in
Restless Legs Syndrome
1 year ago
FUS PTT in Switzerland - 2 years update.
I leave here a copy of a reflextion i posted on my FB Sorry for the english, i'm not a native speaker "January 13, 2023 Exactly 2 years ago today my life changed radically. Exactly 2 years ago today I was in the city of Solothurn, in central Switzerland, undergoing an innovative surgery, in the
I leave here a copy of a reflextion i posted on my FB Sorry for the english, i'm not a native speaker "January 13, 2023 Exactly 2 years ago today my life changed radically. Exactly 2 years ago today I was in the city of Solothurn, in central Switzerland, undergoing an innovative surgery, in the
Markbit
in
Cure Parkinson's
2 years ago
S.Biomedics of Korea Okayed to test stem cell therapy for Parkinson’s disease
The study will evaluate the safety and efficacy of dopamine neural precursor cell transplantation therapy derived from homogeneous embryonic stem cells in patients who have been diagnosed with Parkinson's disease for more than five years. The trial will take place at Severance Hospital in the first half
The study will evaluate the safety and efficacy of dopamine neural precursor cell transplantation therapy derived from homogeneous embryonic stem cells in patients who have been diagnosed with Parkinson's disease for more than five years. The trial will take place at Severance Hospital in the first half
Farooqji
in
Cure Parkinson's
2 years ago
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