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Allergic Reaction to Sinemet?
I posted previously that after being on Pramipexole for over 30 years, I, at the direction of my PCP, completed about 2 weeks ago a transition over an 8 week period from P to Sinemet (100 carbidopa-200 levodopa). The transition went smoothly and I am now on two tablets, one taken at 3 pm and a second
I posted previously that after being on Pramipexole for over 30 years, I, at the direction of my PCP, completed about 2 weeks ago a transition over an 8 week period from P to Sinemet (100 carbidopa-200 levodopa). The transition went smoothly and I am now on two tablets, one taken at 3 pm and a second
robertff3401
in
Restless Legs Syndrome
1 year ago
Interesting Bits of News
Very often, I come across some bit of news that might give a hint about the cause of and/or ways to mitigate (live better with) PD. Sometimes (as is the case with the one below) it's about a review of studies on Alzheimer's. Of course, Alzheimer's isn't the same as PD, but I think many of us recognize
Very often, I come across some bit of news that might give a hint about the cause of and/or ways to mitigate (live better with) PD. Sometimes (as is the case with the one below) it's about a review of studies on Alzheimer's. Of course, Alzheimer's isn't the same as PD, but I think many of us recognize
JAS9
in
Cure Parkinson's
1 year ago
Goat Weed - Neuroprotective
Neuroprotective
Epimedium has been shown to improve cognition and memory and to boost energy.
The anti-inflammatory and antioxidant effects of icariin in the brain reduce various conditions associated with neurodegeneration. This activity, combined with its ability to improve neuronal energy
Neuroprotective
Epimedium has been shown to improve cognition and memory and to boost energy.
The anti-inflammatory and antioxidant effects of icariin in the brain reduce various conditions associated with neurodegeneration. This activity, combined with its ability to improve neuronal energy
Gcf51
in
Cure Parkinson's
1 year ago
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IRL1117, Potential Improvement on Levodopa, May Enter Clinical Trial
IRLAB Therapeutics has selected a dopamine receptor agonist candidate called IRL1117 to advance as a Parkinson’s disease treatment, potentially as a longer-lasting alternative to levodopa with lesser side effects. IRL1117 is designed to be a once-daily oral therapy for the hallmark symptoms of Parkinson
IRLAB Therapeutics has selected a dopamine receptor agonist candidate called IRL1117 to advance as a Parkinson’s disease treatment, potentially as a longer-lasting alternative to levodopa with lesser side effects. IRL1117 is designed to be a once-daily oral therapy for the hallmark symptoms of Parkinson
Farooqji
in
Cure Parkinson's
1 year ago
I don't know what this Melatonin blurb is trying to say
From this article: Antioxidants and Prooxidants: Effects on Health and Aging 2020 https://www.hindawi.com/journals/omcl/2020/2360872/ This line: [u]
In addition, administration of melatonin to humans promoted reduction of COX-2 activity, nitrites and nitrates, and lipid peroxides that correlated with
From this article: Antioxidants and Prooxidants: Effects on Health and Aging 2020 https://www.hindawi.com/journals/omcl/2020/2360872/ This line: [u]
In addition, administration of melatonin to humans promoted reduction of COX-2 activity, nitrites and nitrates, and lipid peroxides that correlated with
Bolt_Upright
in
Cure Parkinson's
1 year ago
Neurogenesis Cheat Sheet
Cheat Sheet Neurogenesis 1. Promote MANF Cistanche 1 DHA 2 Lithium 3 Black Pepper 4 2. Promote Nurr1 Melatonin 5-6 Astragalus 7 ////////////References 1. Lin, Y. et al. Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum
Cheat Sheet Neurogenesis 1. Promote MANF Cistanche 1 DHA 2 Lithium 3 Black Pepper 4 2. Promote Nurr1 Melatonin 5-6 Astragalus 7 ////////////References 1. Lin, Y. et al. Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum
House2
in
Cure Parkinson's
1 year ago
What to try next?
My 69 year old HwP has had tremor dominant PD for the past 7 years - taking only Azilect (that he started a year ago). The tremor is much worse, embarrassing him at work, so he needs more therapy. Shooting pain in one foot (and numbness in both) is another recent problem. The neurologist prescribed
My 69 year old HwP has had tremor dominant PD for the past 7 years - taking only Azilect (that he started a year ago). The tremor is much worse, embarrassing him at work, so he needs more therapy. Shooting pain in one foot (and numbness in both) is another recent problem. The neurologist prescribed
goldengrove
in
Cure Parkinson's
1 year ago
256+ Ways To Increase Dopamine Naturally (Supplements And Genetics)
https://mybiohack.com/blog/all-ways-increase-dopamine-naturally
https://mybiohack.com/blog/all-ways-increase-dopamine-naturally
Farooqji
in
Cure Parkinson's
1 year ago
Iron metabolism in RLS : iron transporter ferroportin & Magnesium Malate
Editing to preface: The important subject of iron metabolism deserves a much better post than this. I apologize for how confusing, messy, and inconsistent it is. Please disregard it or take it with a grain of salt. I would erase it but out of respect for the comments made, I wont. I cut and pasted
Editing to preface: The important subject of iron metabolism deserves a much better post than this. I apologize for how confusing, messy, and inconsistent it is. Please disregard it or take it with a grain of salt. I would erase it but out of respect for the comments made, I wont. I cut and pasted
Little_apple
in
Restless Legs Syndrome
1 year ago
“The three amino acids that are most effective at increasing dopamine levels are l-tyrosine, L-dopa, and phenylalanine.”
Anyone using these in combination? I think adding SAM-e to this might work synergistically? I’m learning other means of increasing dopamine to wean off of Azilect.
Anyone using these in combination? I think adding SAM-e to this might work synergistically? I’m learning other means of increasing dopamine to wean off of Azilect.
Little_apple
in
Cure Parkinson's
1 year ago
Edited: PD increases chance of RLS.(yes) Azilect worsens RLS.(wrong) Ambroxol, being an antihistamine I believe worsens RLS.(incorrect)
Edited to state that: I was wrong! Editing my edit: (yes, I know, but I’m trying) Not only do dopamine agonists make RLS worse but so do meds that increase dopamine. Azilect was not mentioned specifically but increasing dopamine is a “cause of RLS augmentation.” Levodopa increases augmentation meaning
Edited to state that: I was wrong! Editing my edit: (yes, I know, but I’m trying) Not only do dopamine agonists make RLS worse but so do meds that increase dopamine. Azilect was not mentioned specifically but increasing dopamine is a “cause of RLS augmentation.” Levodopa increases augmentation meaning
Little_apple
in
Cure Parkinson's
1 year ago
SAM-e is it beneficial to Parkinson’s? It increases dopamine
Animal studies show that chronic SAMe administration increases dopaminergic tone in brain regions, including rat striatum (24), and increases CNS beta-adrenergic receptor density and activity (25,26). Thus, studies of central monoaminergic neurotransmitters support proposed mechanisms for SAMe antidepressant
Animal studies show that chronic SAMe administration increases dopaminergic tone in brain regions, including rat striatum (24), and increases CNS beta-adrenergic receptor density and activity (25,26). Thus, studies of central monoaminergic neurotransmitters support proposed mechanisms for SAMe antidepressant
Little_apple
in
Cure Parkinson's
1 year ago
Be careful with B6/P5P
I have been toxic on B6 for quite some time with dosing just 30-40 mg of P5P. I only figured it out after running out of the supplement. It really made me more anxious and depressed and made my gait very strange. Modern medicine says that under 100mg is safe. Looking back, the worsening of symptoms
I have been toxic on B6 for quite some time with dosing just 30-40 mg of P5P. I only figured it out after running out of the supplement. It really made me more anxious and depressed and made my gait very strange. Modern medicine says that under 100mg is safe. Looking back, the worsening of symptoms
38yroldmale
in
Cure Parkinson's
1 year ago
RLS and iron metabolism and treating with dopamine agonists causes dopamine burnout
“That is exactly why almost any doctor you see prescribes dopamine-stimulating drugs for restless legs.But this logic is flawed, and even they know this. Here’s why.The biggest problem with restless legs is the bulk of your receptors that are SUPPOSED to receive dopamine aren’t receiving it. [2] Restless
“That is exactly why almost any doctor you see prescribes dopamine-stimulating drugs for restless legs.But this logic is flawed, and even they know this. Here’s why.The biggest problem with restless legs is the bulk of your receptors that are SUPPOSED to receive dopamine aren’t receiving it. [2] Restless
Little_apple
in
Cure Parkinson's
1 year ago
Stopping Azilect to change to Macuna? I need help.
Dopamine agonists worsen RLS over time (proven) and I believe in my case may have caused it. Finding this out has changed my opinion of Azilect. I was hopeful it might be Neuroprotective because of it being a Mao-B inhibitor but, it’s causing worsened RLS is the antithesis of Neuroprotective. (On a
Dopamine agonists worsen RLS over time (proven) and I believe in my case may have caused it. Finding this out has changed my opinion of Azilect. I was hopeful it might be Neuroprotective because of it being a Mao-B inhibitor but, it’s causing worsened RLS is the antithesis of Neuroprotective. (On a
Little_apple
in
Cure Parkinson's
1 year ago
Ketogenic Diet Parkinson's
Parkinson’s disease (PD) is a frequently observed neurodegenerative disease of the brain, the incidence of which has doubled since 1990. It develops particularly in elderly people, namely, in 1% of individuals aged over 60 years, although it is increasingly diagnosed in persons at a young age. It is
Parkinson’s disease (PD) is a frequently observed neurodegenerative disease of the brain, the incidence of which has doubled since 1990. It develops particularly in elderly people, namely, in 1% of individuals aged over 60 years, although it is increasingly diagnosed in persons at a young age. It is
House2
in
Cure Parkinson's
1 year ago
chatGPT's opinion on PD - Simple and wise
Unfortunately, there is no cure for Parkinson's disease, but there are several treatments available that can help manage the symptoms and improve quality of life. Here are some of the most common approaches to treating Parkinson's disease: Medications: There are several types of medications that
Unfortunately, there is no cure for Parkinson's disease, but there are several treatments available that can help manage the symptoms and improve quality of life. Here are some of the most common approaches to treating Parkinson's disease: Medications: There are several types of medications that
Xenos
in
Cure Parkinson's
1 year ago
MAOI for depression in Parkinson’s
I’ve been through everything for my Parkinson’s depression and anxiety anhedonia disorder but nothing touches it. Recently started Rasagiline which I’ve been on for about a month but not feeling anything from it. Next suggestion from my neuro psychiatrist is moclobimide but I read it doesn’t increase
I’ve been through everything for my Parkinson’s depression and anxiety anhedonia disorder but nothing touches it. Recently started Rasagiline which I’ve been on for about a month but not feeling anything from it. Next suggestion from my neuro psychiatrist is moclobimide but I read it doesn’t increase
Schofield81
in
Cure Parkinson's
1 year ago
More on the biomarker NFL
The identification of disease-modifying therapies is the Holy Grail of PD research, but to date no drug has been approved as such a therapy.1 There are numerous disease-modifying therapies currently in the pipeline attempting to modify the underlying pathomechanisms. In recent years, the results of
The identification of disease-modifying therapies is the Holy Grail of PD research, but to date no drug has been approved as such a therapy.1 There are numerous disease-modifying therapies currently in the pipeline attempting to modify the underlying pathomechanisms. In recent years, the results of
House2
in
Cure Parkinson's
1 year ago
Review of Genetic and Gene Therapy for Parkinson’s Disease
vFollowing Alzheimer's, PD has the highest number of neuronal degeneration among all neurodegenerative disorders. Deficiency of dopamine in the basal ganglia precedents motor symptoms, viz, later postural unsteadiness, rigidity, tremor, and bradykinesia. PD in most cases is instigated by an amalgamation
vFollowing Alzheimer's, PD has the highest number of neuronal degeneration among all neurodegenerative disorders. Deficiency of dopamine in the basal ganglia precedents motor symptoms, viz, later postural unsteadiness, rigidity, tremor, and bradykinesia. PD in most cases is instigated by an amalgamation
Farooqji
in
Cure Parkinson's
1 year ago
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