Cheat Sheet Neurogenesis
1. Promote MANF
Cistanche 1
DHA 2
Lithium 3
Black Pepper 4
2. Promote Nurr1
Melatonin 5-6
Astragalus 7
////////////References
1. Lin, Y. et al. Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson’s Disease. Evid.-Based Complement. Altern. Med. ECAM 2020, 1818307 (2020).
2. Belayev, L. et al. DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke. CNS Neurosci. Ther. 26, 1155–1167 (2020).
3. Abu-Hijleh, F. A. et al. Novel mechanism of action for the mood stabilizer lithium. Bipolar Disord. 23, 76–83 (2021).
4. Guo, J. et al. Piperine ameliorates SCA17 neuropathology by reducing ER stress. Mol. Neurodegener. 13, 4 (2018).
5. Sharma, R., Ottenhof, T., Rzeczkowska, P. A. & Niles, L. P. Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells. J. Pineal Res. 45, 277–284 (2008).
6. Niles, L. P., Sathiyapalan, A., Bahna, S., Kang, N. H. & Pan, Y. Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain. Int. J. Neuropsychopharmacol. 15, 1343–1350 (2012).
7. Gao, H., Dou, L., Shan, L., Sun, Y. & Li, W. Proliferation and committed differentiation into dopamine neurons of neural stem cells induced by the active ingredients of radix astragali. Neuroreport 29, 577–582 (2018).
Stem Cells Trials
