Animal studies show that chronic SAMe administration increases dopaminergic tone in brain regions, including rat striatum (24), and increases CNS beta-adrenergic receptor density and activity (25,26). Thus, studies of central monoaminergic neurotransmitters support proposed mechanisms for SAMe antidepressant effects.Dec 1, 2017
Sounds like it does everything but the dishes. It increases glutathione.
S-adenosylmethionine plays a role in methylation, a vital process that supports a number of biochemical reactions in the body, including the brain. Because the ability to methylate declines with age, the risk of neurodegenerative diseases, like Alzheimer’s, increases. Evidence indicates that SAM-e levels are lower in patients with Alzheimer’s, which may compromise their metabolism and brain function. (11)Also, S-adenosylmethionine is involved in glutathione production, a powerful antioxidant that works from within the cell. Studies suggest that decreased glutathione levels may be involved in the pathology of Alzheimer’s and other neurodegenerative diseases. (12)Like most benefits associated with S-adenosylmethionine, it’s still unclear whether or not the supplement can definitely improve cognitive impairment in humans, but there are some promising animal studies on the topic.An animal model meta-analysis that was published in PLoS One evaluated the effect of SAM-e on cognitive ability as measured by maze performance in mice. Maze performance is used to measure a rodent’s spatial learning and memory. After reviewing 13 experiments, researchers indicated that supplementing with SAM-e improved cognitive performance, especially in mice that were deficient in folate. They concluded that S-adenosylmethionine “may be useful in improving spatial memory in patients suffering from many dementia forms including Alzheimer’s disease.” (13)
@People who have a weakened immune system may be at increased risk of an infection caused by bacteria known as pneumocystis. SAMe may boost this microorganism's growth.”
Levodopa. SAMe might reduce the effectiveness of levodopa (Inbrija), a medication used to treat Parkinson's disease.
Preliminary evidence suggests that SAMe may improve cognitive symptoms, such as the ability to recall information and remember words. Researchers suspect SAMe acts on regions of the brain that regulate gene expression of amyloid proteins, one of the hallmarks of Alzheimer disease.Other Some studies suggest SAMe can effectively inhibit cancer tumor cells. Other studies suggest that taking the drug levodopa (L-dopa) for Parkinson disease may lower the levels of SAMe in the body, which may contribute to depression and increase the side effects of L-dopa. However, researchers have also found evidence that taking SAMe may make L-dopa less effective. If you have Parkinson disease, do not take SAMe without talking to your doctor first.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Dopamine
Chicory extracts increase neuronal survival in Parkinson’s 
Newly Discovered Trigger of Parkinson’s Upends Common Beliefs
How to Prevent/Reverse Dopamine Receptor Downregulation from Dopamine Agonists, Stimulants and other Causes 
Dopamine the problem? 
