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Dapagliflozin / Metformin
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The Impact of Metformin Use with Survival Outcomes.
New meta-analysis below [1]. "27 eligible studies were identified, including 123,212 participants. "In prostate cancer, patients using metformin have significant benefits for: ... recurrence (HR = 0.74 ...), ...{cancer-specific survival} (HR = 0.74 ...), and ... {overall survival} (HR = 0.76 ...).
New meta-analysis below [1]. "27 eligible studies were identified, including 123,212 participants. "In prostate cancer, patients using metformin have significant benefits for: ... recurrence (HR = 0.74 ...), ...{cancer-specific survival} (HR = 0.74 ...), and ... {overall survival} (HR = 0.76 ...).
pjoshea13
in
Advanced Prostate Cancer
3 years ago
SGLT2 new treatment for CDK; anyone on them?
I was listen to a Dr. in a podcast regarding new treatment for CDK. Even though these sodium inhibitors are used for heart patience and diabetics, they are showing promising results for non-diabetics with CKD and proteinuria. "Despite optimal treatment with renin-angiotensin-aldosterone-system (RAAS
I was listen to a Dr. in a podcast regarding new treatment for CDK. Even though these sodium inhibitors are used for heart patience and diabetics, they are showing promising results for non-diabetics with CKD and proteinuria. "Despite optimal treatment with renin-angiotensin-aldosterone-system (RAAS
RoxanneKidney
in
Kidney Disease
3 years ago
blood sugar control
having trouble controlling after breakfast bs spikes. Take metformin and glimepiride but am spikes frequently around 215. Any suggestions?? Last a1c was 6.3 so overall bs has improved.
having trouble controlling after breakfast bs spikes. Take metformin and glimepiride but am spikes frequently around 215. Any suggestions?? Last a1c was 6.3 so overall bs has improved.
mickeyba1
in
Kidney Disease
3 years ago
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Are you on ADT? Many/Most of us are. THIS IS A MUST WATCH VIDEO. 3 key points: Statins, Degelrix, Metformin. Grand Rounds in Urology.Mike
https://youtu.be/6duRbpY-WkI
https://youtu.be/6duRbpY-WkI
Spyder54
in
Advanced Prostate Cancer
3 years ago
Meds for Patient with HF with reduced Ejection fraction ( HF r EF )
Hello saw the Heart Nurse today first time in 18months she wants to introduce Forxiga ( dapagliflozin ) into the mix !! I currently take 7.5mg Bisoprolol one a day, Eplerenone 25mg one every other day, Omeprazole 20mg one a day, Entresto 49/51mg twice a day, Aspirin 75mg one a day, Pravastatin 10mg one
Hello saw the Heart Nurse today first time in 18months she wants to introduce Forxiga ( dapagliflozin ) into the mix !! I currently take 7.5mg Bisoprolol one a day, Eplerenone 25mg one every other day, Omeprazole 20mg one a day, Entresto 49/51mg twice a day, Aspirin 75mg one a day, Pravastatin 10mg one
Prada47
in
British Heart Foundation
3 years ago
Poor Circulation- does anyone else have this issue?
I have been having issues with the circulation to my hands and feet for a couple of years’ now. I only see my feet before I get dressed in the morning and after I undress in the evening but at those times they always look a very unhealthy shade of purple. My hands vary throughout the day and sometimes
I have been having issues with the circulation to my hands and feet for a couple of years’ now. I only see my feet before I get dressed in the morning and after I undress in the evening but at those times they always look a very unhealthy shade of purple. My hands vary throughout the day and sometimes
Crystalbowl
in
AF Association
3 years ago
Metformin,T2 Diabetes & hypothyroidism … effects?
Metformin lowers TSH https://www.cureus.com/articles/50564-exploring-the-effect-of-metformin-to-lower-thyroid-stimulating-hormone-in-euthyroid-and-hypothyroid-type-2-diabetic-patients Any link with A breakthrough-like effect of metformin reduces peripheral resistance to triiodothyronine in euthyroid,
Metformin lowers TSH https://www.cureus.com/articles/50564-exploring-the-effect-of-metformin-to-lower-thyroid-stimulating-hormone-in-euthyroid-and-hypothyroid-type-2-diabetic-patients Any link with A breakthrough-like effect of metformin reduces peripheral resistance to triiodothyronine in euthyroid,
MikeM46
in
Thyroid UK
3 years ago
Metformin - 4th transfer
Hi all, I'm back ahead of my 4th transfer. 2 unsuccessful, 1 ending in MMC after 9 weeks (Heartbeat seen, all going well, other than bleeding). I have also had one previous natural miscarriage. I have been found to have insulin resistance following a blood test and have been prescribed Metformin.
Hi all, I'm back ahead of my 4th transfer. 2 unsuccessful, 1 ending in MMC after 9 weeks (Heartbeat seen, all going well, other than bleeding). I have also had one previous natural miscarriage. I have been found to have insulin resistance following a blood test and have been prescribed Metformin.
strawberriesandcream
in
Fertility Network UK
3 years ago
Medication problems
Suffering with upper back and lower back pain, think it’s the one of the latest medication for diabetes and anticoagulant. Apixaban, metformin , Gliclazide Not had this pain since my partial knee replacement in 2019! Can anyone enlighten me please?
Suffering with upper back and lower back pain, think it’s the one of the latest medication for diabetes and anticoagulant. Apixaban, metformin , Gliclazide Not had this pain since my partial knee replacement in 2019! Can anyone enlighten me please?
LaceyLady
in
Atrial Fibrillation Support
3 years ago
Neuroprotective effect of rapamycin against Parkinson's disease in mice - 2018 https://pubmed.ncbi.nlm.nih.gov/30693687/
Conclusions: Rapamycin inhibits the activation of mTOR pathway, which contributes to protect against the loss of dopaminergic neurons and provide behavioral improvements in mice with Parkinson's disease. These results are partially related to the ability of rapamycin in inducing autophagy and reducing
Conclusions: Rapamycin inhibits the activation of mTOR pathway, which contributes to protect against the loss of dopaminergic neurons and provide behavioral improvements in mice with Parkinson's disease. These results are partially related to the ability of rapamycin in inducing autophagy and reducing
Bolt_Upright
in
Cure Parkinson's
3 years ago
Methotrexate? Is it too soon to go onto this drug
Hi everyone, I was diagnosed with PMR in August 2020 and have found this forum invaluable over the past 13 months. This is my first post as so far I have always found the answer to my questions somewhere on the site. However on this occasion I would really appreciate some advice. I’ve just updated
Hi everyone, I was diagnosed with PMR in August 2020 and have found this forum invaluable over the past 13 months. This is my first post as so far I have always found the answer to my questions somewhere on the site. However on this occasion I would really appreciate some advice. I’ve just updated
Tiggy70
in
PMRGCAuk
3 years ago
To take metformin or not?
Hi all 👋🏻 Think I’m having a last minute wobble but wanting to get some other opinions. I have PCOS and in the past have had 60+ day cycles. I pushed the clinic to give me metformin which (no surprise) made me feel crap so when I got covid in august I stopped taking it after only 3 weeks and never
Hi all 👋🏻 Think I’m having a last minute wobble but wanting to get some other opinions. I have PCOS and in the past have had 60+ day cycles. I pushed the clinic to give me metformin which (no surprise) made me feel crap so when I got covid in august I stopped taking it after only 3 weeks and never
RecipIVF
in
Fertility Network UK
3 years ago
Looking for anyone else with the RAD51B mutation with mets to liver.
New here but not new to Prostate cancer. I'm writing for my dad that was first diagnosed with prostate cancer in October 2010 via digital exam when PSA was only 2.8. Had robotic surgery Feb. 2011 - post Gleason Score 7 (4+3) minor component pattern 5, margins clean and no Seminal Vesicle involvement
New here but not new to Prostate cancer. I'm writing for my dad that was first diagnosed with prostate cancer in October 2010 via digital exam when PSA was only 2.8. Had robotic surgery Feb. 2011 - post Gleason Score 7 (4+3) minor component pattern 5, margins clean and no Seminal Vesicle involvement
Dadslove
in
Advanced Prostate Cancer
3 years ago
New to the site
Hi, I'm new to this site although registered for the CLL site. I'm a 72 yr old male with a history of high blood glucose and on metformin 500mg x2. In May of 2020 I began treatment for CLL which included both infusion (obinutuzumab) and oral (venetoclax) meds. Just after starting the infusions which
Hi, I'm new to this site although registered for the CLL site. I'm a 72 yr old male with a history of high blood glucose and on metformin 500mg x2. In May of 2020 I began treatment for CLL which included both infusion (obinutuzumab) and oral (venetoclax) meds. Just after starting the infusions which
marrix
in
Diabetes Support
3 years ago
Side affects of Spironolactone and Metformin
PCOS Spironolactone and metformin Pills…. I was diagnosed as have insulin resistant PCOS three months ago. I went to the docs due to excessive groin sweating being very hairy and headaches…. My blood showed high testosterone and something else sorry can’t remember so this with the symptoms led to
PCOS Spironolactone and metformin Pills…. I was diagnosed as have insulin resistant PCOS three months ago. I went to the docs due to excessive groin sweating being very hairy and headaches…. My blood showed high testosterone and something else sorry can’t remember so this with the symptoms led to
New-start2021
in
PCOS UK (Verity)
3 years ago
Metformin
I am on the maximum dose of Metformin. I find the laxative, breathing and shivering side-effects to be debilitating. My diabetes nurse is unwilling to change to an alternative so I have booked to see my GP. She said I wasn't drinking enough water but I am drinking 3 pints a day. I am just flushing it
I am on the maximum dose of Metformin. I find the laxative, breathing and shivering side-effects to be debilitating. My diabetes nurse is unwilling to change to an alternative so I have booked to see my GP. She said I wasn't drinking enough water but I am drinking 3 pints a day. I am just flushing it
bionicjohn
in
Diabetes & Hypertension Help Society
3 years ago
Dapavlifozin
I'm on dapagliflozin for heart failure and I'm having pins and needles in legs and feeling very dizzy, iv now been took off them, can I go on another drug to help me. Lynn
I'm on dapagliflozin for heart failure and I'm having pins and needles in legs and feeling very dizzy, iv now been took off them, can I go on another drug to help me. Lynn
Bigsock1234
in
British Heart Foundation
3 years ago
New member looking for advice
EDIT 2: Found New blood test where TSH is now up to 5.63 (only 3 months distance from previous test which showed 4.5!) FT4 was 16 however which is within range. But also showed MCH, MCHC and MCV borderline which could be related to iron deficient anaemia apparently. Test pic below. EDIT: oh wow! This
EDIT 2: Found New blood test where TSH is now up to 5.63 (only 3 months distance from previous test which showed 4.5!) FT4 was 16 however which is within range. But also showed MCH, MCHC and MCV borderline which could be related to iron deficient anaemia apparently. Test pic below. EDIT: oh wow! This
OudMood
in
Thyroid UK
3 years ago
Metformin Recall
Rosemont Pharmaceuticals is recalling some batches of Metformin. I am posting it as it is something easily missed.
Please see:
https://www.gov.uk/drug-device-alerts/class-2-medicines-recall-rosemont-pharmaceuticals-limited-metformin-hydrochloride-500mg-slash-5ml-oral-solution-pl-00427-slash
Rosemont Pharmaceuticals is recalling some batches of Metformin. I am posting it as it is something easily missed.
Please see:
https://www.gov.uk/drug-device-alerts/class-2-medicines-recall-rosemont-pharmaceuticals-limited-metformin-hydrochloride-500mg-slash-5ml-oral-solution-pl-00427-slash
MichaelJH
in
Diabetes Research & Wellness Foundation
3 years ago
Metformin Recall
I know a number of you here have Type II diabetes. Rosemont Pharmaceuticals are recalling some batches of Metformin. I am posting it as it is something easily missed. https://www.gov.uk/drug-device-alerts/class-2-medicines-recall-rosemont-pharmaceuticals-limited-metformin-hydrochloride-500mg-slash-5ml-oral-solution-pl
I know a number of you here have Type II diabetes. Rosemont Pharmaceuticals are recalling some batches of Metformin. I am posting it as it is something easily missed. https://www.gov.uk/drug-device-alerts/class-2-medicines-recall-rosemont-pharmaceuticals-limited-metformin-hydrochloride-500mg-slash-5ml-oral-solution-pl
MichaelJH
Heart Star
in
British Heart Foundation
3 years ago
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