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Acalabrutinib, venetoclax and obinutuzumab in relapsed CLL: Phase 2 CLL2-BAAG trial results from the German CLL Study Group
Some very encouraging news for those with unmutated IGHV and/or TP53 aberrations, who are wondering how they will fare with a subsequent treatment. This phase 2 trial of 44 relapsed patients included 34 (75.6%) who had unmutated IGHV and 14/44 (31.8%) who had TP53 aberrations. A Measurable Residual
Some very encouraging news for those with unmutated IGHV and/or TP53 aberrations, who are wondering how they will fare with a subsequent treatment. This phase 2 trial of 44 relapsed patients included 34 (75.6%) who had unmutated IGHV and 14/44 (31.8%) who had TP53 aberrations. A Measurable Residual
AussieNeil
Partner
in
CLL Support
3 months ago
IVF PGT pregnancy - high HCG at screening (low risk)
Hi everyone. I am currently 15 weeks pregnant with my first baby. It is an IVF pregnancy and it’s a PGT normal embryo that we transferred. Despite having a normal embryo we opted for combined screening. My results have come back low risk for my age - 1:260 and I’m aged 40. My NT was 1.9mm (mom = 1
Hi everyone. I am currently 15 weeks pregnant with my first baby. It is an IVF pregnancy and it’s a PGT normal embryo that we transferred. Despite having a normal embryo we opted for combined screening. My results have come back low risk for my age - 1:260 and I’m aged 40. My NT was 1.9mm (mom = 1
GB844
in
Fertility Network UK - Pregnancy Support
1 month ago
High HCG at screening - IVF pregnancy
Hi everyone. I am currently 15 weeks pregnant with my first baby. It is an IVF pregnancy and it’s a PGT normal embryo that we transferred. Meaning it was testing and deemed to have the correct number of chromosomes before being transferred. The false negative chance of this is low at around 1-2%.
Hi everyone. I am currently 15 weeks pregnant with my first baby. It is an IVF pregnancy and it’s a PGT normal embryo that we transferred. Meaning it was testing and deemed to have the correct number of chromosomes before being transferred. The false negative chance of this is low at around 1-2%.
GB844
in
Pregnancy and Parenting Support
1 month ago
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Single blastocyst FET day 12 hcg 98- any hope?
biochemical 3 months ago- double FET
biochemical 3 months ago- double FET
Responsible
in
Fertility Network UK
2 months ago
Help! 2WW struggles
After many years of TTC we had a double A grade embryo transfer on the 24/05. We are now 9dp5dt. I am really really struggling with my thoughts and fears and just thought this would be the best place to express them. These are our last 2 embryos and we’ve put everything into this cycle. For the
After many years of TTC we had a double A grade embryo transfer on the 24/05. We are now 9dp5dt. I am really really struggling with my thoughts and fears and just thought this would be the best place to express them. These are our last 2 embryos and we’ve put everything into this cycle. For the
BethanyDavey
in
Fertility Network UK
2 months ago
8DP5DT - FRER Line Progression
The first test was 6dp5dt at 5am The second test was 7dp5dt at 9pm (had time to darken which doesn't help) Third test was this morning at 5am. I also did a clear blue digital yesterday morning and got a big old positive I know that HCG doubles every 48-72 hours. I know that you should take the same
The first test was 6dp5dt at 5am The second test was 7dp5dt at 9pm (had time to darken which doesn't help) Third test was this morning at 5am. I also did a clear blue digital yesterday morning and got a big old positive I know that HCG doubles every 48-72 hours. I know that you should take the same
SurrogateFriend
in
Fertility Network UK
2 months ago
Both LH and HCG positive
This is my 6th week since first miscarriage. I have confirmed negative hcg 3 times before. Have been tracking my LH just to see how my body is reacting, which as usual started with very low LH. I'm getting high LH now since 5 days, I never ovulated on my own before (atleast never checked) and I was suspicious
This is my 6th week since first miscarriage. I have confirmed negative hcg 3 times before. Have been tracking my LH just to see how my body is reacting, which as usual started with very low LH. I'm getting high LH now since 5 days, I never ovulated on my own before (atleast never checked) and I was suspicious
Hope_1996
in
Fertility Network UK
2 months ago
Low vitamin d high serum ferritin
Hello My husband has been on watch and wait for 12 years. Due to a constant chronic cough he recently had a blood test which showed low vitamin D levels of 45 and high serum ferritin levels of 936. He has been referred back to haematology but in the meantime just wondering if anyone can tell me if there
Hello My husband has been on watch and wait for 12 years. Due to a constant chronic cough he recently had a blood test which showed low vitamin D levels of 45 and high serum ferritin levels of 936. He has been referred back to haematology but in the meantime just wondering if anyone can tell me if there
Debs4
in
CLL Support
3 months ago
Worried tests are getting lighter / hook effect
I'm really worried and sorry to be asking again. But I did a test today (5+6) after disappearance of my only symptom and the test was quite light (bottom test) compared to the one i did about 5 days ago. I had heard of the hook effect so tried it by diluting with water (top test) and the test line did
I'm really worried and sorry to be asking again. But I did a test today (5+6) after disappearance of my only symptom and the test was quite light (bottom test) compared to the one i did about 5 days ago. I had heard of the hook effect so tried it by diluting with water (top test) and the test line did
Skittles11
in
Fertility Network UK - Pregnancy Support
2 months ago
Low HCG levels
Hi all, just looking for some hope I guess. I had 5day FET. Was testing positive lightly from day 6. Has blood test 12 days after it was 72 then 4 days later was 205. Now I'm going to have my 3rd test today. Dr said it doesn't sound very promising 😔 my urine tests have progressively got darker but no
Hi all, just looking for some hope I guess. I had 5day FET. Was testing positive lightly from day 6. Has blood test 12 days after it was 72 then 4 days later was 205. Now I'm going to have my 3rd test today. Dr said it doesn't sound very promising 😔 my urine tests have progressively got darker but no
joanne2024
in
Fertility Network UK
2 months ago
Testing out the trigger
Curious to know when people got the first clear negative if you tested out the trigger? I took Ovitrelle 250 9 days ago and I am now 2dp5dt. I did a test today as I wanted to be sure the trigger was gone from my system but there was a clear but faint second line. Internet says it can stay for up
Curious to know when people got the first clear negative if you tested out the trigger? I took Ovitrelle 250 9 days ago and I am now 2dp5dt. I did a test today as I wanted to be sure the trigger was gone from my system but there was a clear but faint second line. Internet says it can stay for up
BlahBlah55
in
Fertility Network UK
2 months ago
*Sensitive* 6 weeks 3 days empty sac *UPDATE*
Hi girls, Sorry if you don't need to read this today - please scroll on by. I'm after a bit of reassurance really - I had good HCG on OTD and had my viability scan today - unfortunately the dr was only able to see an empty sac. No foetal pole or yolk. I'm desperately hoping it's too early but my
Hi girls, Sorry if you don't need to read this today - please scroll on by. I'm after a bit of reassurance really - I had good HCG on OTD and had my viability scan today - unfortunately the dr was only able to see an empty sac. No foetal pole or yolk. I'm desperately hoping it's too early but my
Millbanks
in
Fertility Network UK
2 months ago
late progynova dose at 4w5d (FET) - looking for reassurance
hi. I’m 4w5d pregnant following FET. I’m on quite a lot of medication due to having trouble getting my lining to thicken - 2x Cyclogest pessaries (taken rectally for the last 3 weeks because of irritation), 1x lubion injection, 6x2mg progynova tablets, and also estradiol patches 2x per week. On Tuesday
hi. I’m 4w5d pregnant following FET. I’m on quite a lot of medication due to having trouble getting my lining to thicken - 2x Cyclogest pessaries (taken rectally for the last 3 weeks because of irritation), 1x lubion injection, 6x2mg progynova tablets, and also estradiol patches 2x per week. On Tuesday
emma_g87
in
Fertility Network UK
2 months ago
Reassurance about clear blue digital tests.
Hi all When did people see 3+ weeks on there clear blue digital tests? I am currently 5 weeks and 4 days. My HCG levels on the 13th was 592 so by now should be over in the 9000 area. I have not had this retested. My test from this afternoon has read 2-3 weeks still. So I am now worried I am experiencing
Hi all When did people see 3+ weeks on there clear blue digital tests? I am currently 5 weeks and 4 days. My HCG levels on the 13th was 592 so by now should be over in the 9000 area. I have not had this retested. My test from this afternoon has read 2-3 weeks still. So I am now worried I am experiencing
Lulu9345
in
Fertility, Miscarriage & IVF Support
2 months ago
Symptoms - where are they?
Hi, I’m 5wk 5 days - FET and I have zero symptoms. I know it’s still early but I almost want them all to bring some reassurance. Yes I would say I’m more tired; but then I’m always tired 😂 but other than that nothing! I had my hcg bloods at 4+5 and repeated at 5 weeks and they had all but doubled (
Hi, I’m 5wk 5 days - FET and I have zero symptoms. I know it’s still early but I almost want them all to bring some reassurance. Yes I would say I’m more tired; but then I’m always tired 😂 but other than that nothing! I had my hcg bloods at 4+5 and repeated at 5 weeks and they had all but doubled (
Toffeepudding99
in
Fertility Network UK - Pregnancy Support
2 months ago
General Question re positive test lines
If you do a test on test day for fet and it were to say you were pregnant are the lines supposed to continue to get darker? Should you keep testing or just wait and do a hcg blood test? As I'm guessing how strong/diluted your urine is will also have impact on the darkness of the line? At what point would
If you do a test on test day for fet and it were to say you were pregnant are the lines supposed to continue to get darker? Should you keep testing or just wait and do a hcg blood test? As I'm guessing how strong/diluted your urine is will also have impact on the darkness of the line? At what point would
Flora14
in
Fertility Network UK
2 months ago
10 days post fresh embryo transfer
Hi everyone. Hope we are holding up. Please is it possible to get a urine positive test 9 or 10 days past embryo fresh transfer. I.e 16 days past hcg trigger injection? Really feel like testing😢
Hi everyone. Hope we are holding up. Please is it possible to get a urine positive test 9 or 10 days past embryo fresh transfer. I.e 16 days past hcg trigger injection? Really feel like testing😢
FioFio
in
Fertility Network UK
2 months ago
HCG Result- 9dpt
Hello Everyone, I just got my HCG tested today 9dpt , and it is 131.Do you think it is good? My clinic confirmed my pregnancy and booked me for a 6 week scan on the 3rd June. How will I know if my HCG is doubling? This makes me worry now.
Hello Everyone, I just got my HCG tested today 9dpt , and it is 131.Do you think it is good? My clinic confirmed my pregnancy and booked me for a 6 week scan on the 3rd June. How will I know if my HCG is doubling? This makes me worry now.
MrsXX
in
Fertility Network UK
2 months ago
Shocking turn of events and I'm terrified- reassurance appreciated
Hi - sorry in advance for long post!I've had a really shocking turn of events this week (I'm normally on the other forum) and hoping I can get some reassurance. The context is that I've been TTC for 5 years and have tried IVF multiple times. Had an early natural miscarriage back in 2020. In 2021 for
Hi - sorry in advance for long post!I've had a really shocking turn of events this week (I'm normally on the other forum) and hoping I can get some reassurance. The context is that I've been TTC for 5 years and have tried IVF multiple times. Had an early natural miscarriage back in 2020. In 2021 for
Skittles11
in
Fertility Network UK - Pregnancy Support
2 months ago
No Line Progression?? **5DPT to 8DPT**
Hi All, Today is 8DP5DT. I am so terrified that this transfer didn't work, as I cannot see any line progression. Is there any hope? My HCG is booked for tomorrow.
Hi All, Today is 8DP5DT. I am so terrified that this transfer didn't work, as I cannot see any line progression. Is there any hope? My HCG is booked for tomorrow.
MrsXX
in
Fertility Network UK
2 months ago
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