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Dr Slovin from MSKCC discusses treatments for advanced prostate cancer
Latest approaches to
Castration
Resistant Prostate Cancer, for patients who need to know https://youtu.be/7e51R8KPOsI
Latest approaches to
Castration
Resistant Prostate Cancer, for patients who need to know https://youtu.be/7e51R8KPOsI
Darryl
Partner
in
Advanced Prostate Cancer
1 year ago
CART trial, just FYI
The use of prostate stem cell antigen–targeted CAR T-cell therapy was well tolerated and produced evidence of anticancer effects in patients with metastatic
castration
-resistant prostate cancer. https://www.onclive.com/view/psca-targeted-car-t-cell-therapy-demonstrates-safety-anticancer-activity-in-mcrpc
The use of prostate stem cell antigen–targeted CAR T-cell therapy was well tolerated and produced evidence of anticancer effects in patients with metastatic
castration
-resistant prostate cancer. https://www.onclive.com/view/psca-targeted-car-t-cell-therapy-demonstrates-safety-anticancer-activity-in-mcrpc
Bkraus1
in
Advanced Prostate Cancer
1 year ago
FDA approves niraparib and abiraterone acetate plus prednisone for BRCA-mutated metastatic castration-resistant prostate cancer - 08/11/2023
.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated
castration
-resistant prostate cancer (mCRPC), as determined by an FDA-approved test.
.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated
castration
-resistant prostate cancer (mCRPC), as determined by an FDA-approved test.
cujoe
in
Fight Prostate Cancer
11 months ago
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#AskChatGPT : list of immunotherapy drugs for prostate cancer
Here are some of the notable ones: Sipuleucel-T (Provenge): Sipuleucel-T is an autologous cellular immunotherapy approved for the treatment of asymptomatic or minimally symptomatic metastatic
castration
-resistant prostate cancer (mCRPC).
Here are some of the notable ones: Sipuleucel-T (Provenge): Sipuleucel-T is an autologous cellular immunotherapy approved for the treatment of asymptomatic or minimally symptomatic metastatic
castration
-resistant prostate cancer (mCRPC).
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Kidney failure and future treatments
After that, he started chemotherapy with DOCETAXEL as the oncologist declared he was
castration
resistant. Since then, he had 3 rounds of chemotherapy and although he seemed to respond well at the very beginning, his PSA went up since this month (it was 10 by the end of March, and 23 now).
After that, he started chemotherapy with DOCETAXEL as the oncologist declared he was
castration
resistant. Since then, he had 3 rounds of chemotherapy and although he seemed to respond well at the very beginning, his PSA went up since this month (it was 10 by the end of March, and 23 now).
Yabaa
in
Advanced Prostate Cancer
1 year ago
Bipolar Androgen Therapy Followed by Androgen Receptor Inhibition as Sequential Therapy for Prostate Cancer
"Studies dating back nearly 30 years indicate that high expression of AR induced by prolonged
castration
becomes a vulnerability of CRPC cells in vitro and in mouse xenografts to supraphysiologic androgen (SPA), which induces cell death and growth arrest in this context."
"Studies dating back nearly 30 years indicate that high expression of AR induced by prolonged
castration
becomes a vulnerability of CRPC cells in vitro and in mouse xenografts to supraphysiologic androgen (SPA), which induces cell death and growth arrest in this context."
pjoshea13
in
Fight Prostate Cancer
1 year ago
Assessing the Benefit of CAR T-cell Therapies for mCRPC
A first-in-human phase 1 trial (NCT03873805) investigated the safety and bioactivity of prostate stem cell antigen-directed CAR T cells for patients with metastatic
castration
-resistant prostate cancer.
A first-in-human phase 1 trial (NCT03873805) investigated the safety and bioactivity of prostate stem cell antigen-directed CAR T cells for patients with metastatic
castration
-resistant prostate cancer.
God_Loves_Me
in
Advanced Prostate Cancer
14 days ago
Fosfestrol (Honvan)
"
Outcomes and toxicity of oral Fosfestrol in metastatic
-resistant prostate cancer-a real-world experience" This brought back memories of being in groups shortly after I was diagnosed.
"
Outcomes and toxicity of oral Fosfestrol in metastatic
-resistant prostate cancer-a real-world experience" This brought back memories of being in groups shortly after I was diagnosed.
pca2004
in
Fight Prostate Cancer
10 months ago
Elevated Body Mass Index Is Associated with Improved Overall Survival
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/145111-elevated-body-mass-index-is-associated-with-improved-overall-survival-in-
castration
-resistant-prostate-cancer-patients-undergoing-prostate-specific-membrane-antigen-directed-radioligand-therapy.html
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/145111-elevated-body-mass-index-is-associated-with-improved-overall-survival-in-
castration
-resistant-prostate-cancer-patients-undergoing-prostate-specific-membrane-antigen-directed-radioligand-therapy.html
Ahk1
in
Advanced Prostate Cancer
1 year ago
Questions about hormone therapy...
From what I can glean, even short-term hormone therapy has the effect of: - chemical
castration
- shrinkage of testicles to the point they cannot be felt - shrinkage of the penis - hot flashes - weight gain - tender breast tissue and breast growth I'm having a hard time wrapping my mind around
From what I can glean, even short-term hormone therapy has the effect of: - chemical
castration
- shrinkage of testicles to the point they cannot be felt - shrinkage of the penis - hot flashes - weight gain - tender breast tissue and breast growth I'm having a hard time wrapping my mind around
JetBoy
in
Prostate Cancer And Gay Men
1 year ago
Does this mean we sould not use ubiquinol?
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/144338-traf4-mediated-nonproteolytic-ubiquitination-of-androgen-receptor-promotes-
castration
-resistant-prostate-cancer.html
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/144338-traf4-mediated-nonproteolytic-ubiquitination-of-androgen-receptor-promotes-
castration
-resistant-prostate-cancer.html
cigafred
in
Fight Prostate Cancer
1 year ago
ADT for almost 2 years
In the event that it grows again, does that mean a recurrency again and that I am
Castration
-resistant? If so is this the end of the line? Some more data: On January 2022 I did a PET scan when PSA was rising, after radiotherapy having failed. It was 0.7 then.
In the event that it grows again, does that mean a recurrency again and that I am
Castration
-resistant? If so is this the end of the line? Some more data: On January 2022 I did a PET scan when PSA was rising, after radiotherapy having failed. It was 0.7 then.
Paulo1968
in
Advanced Prostate Cancer
9 months ago
Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance, Int J Mol Sci. 2022 Nov; 23(21): 13521
Almost all treatments target androgen metabolism pathways and AR, from
castration
-sensitive prostate cancer (CSPC) to
castration
-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance.
Almost all treatments target androgen metabolism pathways and AR, from
castration
-sensitive prostate cancer (CSPC) to
castration
-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance.
cujoe
in
Fight Prostate Cancer
1 year ago
A Phase 1, Open-Label, Multicenter Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer
I have a choice between this trial and a BAT trial. I’m already preferential to BAT, but without being too hasty, I wanted to see if anyone here has any experience with JANX00x before deciding.
I have a choice between this trial and a BAT trial. I’m already preferential to BAT, but without being too hasty, I wanted to see if anyone here has any experience with JANX00x before deciding.
No_stone_unturned
in
Advanced Prostate Cancer
5 months ago
#AskChatGPT - Top ADC Treatment for prostate cancer
Several antibody-drug conjugates (ADCs) are emerging as promising treatments for metastatic
castration
-resistant prostate cancer (mCRPC).
Several antibody-drug conjugates (ADCs) are emerging as promising treatments for metastatic
castration
-resistant prostate cancer (mCRPC).
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Pluvicto after long time androgen deprivation therapy
It certainly seems the case for
castration
-sensitive PC, not sure about
castration
-resistant PC. [i]Continuous long-term ADT significantly reduces the visibility of
castration
-sensitive PC on PSMA PET/CT.
It certainly seems the case for
castration
-sensitive PC, not sure about
castration
-resistant PC. [i]Continuous long-term ADT significantly reduces the visibility of
castration
-sensitive PC on PSMA PET/CT.
MyDad76
in
Advanced Prostate Cancer
1 year ago
The Evolving Role of Diet in Prostate Cancer Risk and Progression
"One of the mechanisms of
castration
resistance may be due to the induced hyperinsulinemia from the reciprocal crosstalk between the androgen-insulin axes. This possibility presents a unique opportunity for dietary intervention, ..." There is a section on that in the paper.
"One of the mechanisms of
castration
resistance may be due to the induced hyperinsulinemia from the reciprocal crosstalk between the androgen-insulin axes. This possibility presents a unique opportunity for dietary intervention, ..." There is a section on that in the paper.
pjoshea13
in
Fight Prostate Cancer
1 year ago
Is nmCRPC potentially curable?
I searched the internet and found this article from Fred Saad: Treatment of nonmetastatic
castration
-resistant prostate cancer: focus on second-generation androgen receptor inhibitors https://www.nature.com/articles/s41391-020-00310-3 I couldn't find anything about radiation therapy or surgery related
I searched the internet and found this article from Fred Saad: Treatment of nonmetastatic
castration
-resistant prostate cancer: focus on second-generation androgen receptor inhibitors https://www.nature.com/articles/s41391-020-00310-3 I couldn't find anything about radiation therapy or surgery related
Seasid
in
Advanced Prostate Cancer
7 months ago
Proteolysis Targeting Chimeras
"[i]The compounds ... significantly inhibit enzalutamide-resistant growth of
castration
resistant prostate cancer (CRPC) cells.
"[i]The compounds ... significantly inhibit enzalutamide-resistant growth of
castration
resistant prostate cancer (CRPC) cells.
pjoshea13
in
Fight Prostate Cancer
1 year ago
BAT therapy - NIH article
Efficacy and safety of bipolar androgen therapy in
castration
-resistant prostate cancer following abiraterone or enzalutamide resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z.
Efficacy and safety of bipolar androgen therapy in
castration
-resistant prostate cancer following abiraterone or enzalutamide resistance: A systematic review. You X, Huang S, Wang X, Yi C, Gong N, Yu J, Xu C, Xiang Z.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
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