Fosfestrol (Honvan): New paper from... - Fight Prostate Ca...

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Fosfestrol (Honvan)

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New paper from India [1].

"Outcomes and toxicity of oral Fosfestrol in metastatic castration-resistant prostate cancer-a real-world experience"

This brought back memories of being in groups shortly after I was diagnosed. There were men who discussed where to obtain Honvan (Forfestrol) a DES (Diethylstilbestrol) prodrug - usually Mexico. Some cut the pills up & managed to control progression with quite low doses. (These days, India may be a better bet than Mexico.)

The study was on men with metastatic CRPC.

"At the end of a median follow-up of 16 months, the median progression-free survival (PFS) was 8.3 months (CI 4.7-11.8) and the median overall survival (OS) was 27.5 months (CI 25.4-29.5)."

however, "patients who ... received prior abiraterone acetate therapy had worse survival outcomes."

A significant attraction of oral Honvan is that it is cheap.

It would be interesting to see how BAT + Honvan might improve survival in metastatic CRPC. (Testosterone cypioanate is also inexpensive.)

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/377...

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