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Immunotherapy for Prostate Cancer: Where Do We Go From Here?—PART 1: Prostate Cancer Vaccines
prostate cancer (NCT02649855), and
castration
-resistant prostate cancer (NCT01867333, NCT02933255) settings.
prostate cancer (NCT02649855), and
castration
-resistant prostate cancer (NCT01867333, NCT02933255) settings.
JLS1
in
Advanced Prostate Cancer
6 years ago
Castration resistant prostate cancer
Hello, I have metastatic prostate cancer (bony metastases). Thus far, I have had 39 radiation treatments, have been on Lupron for over one year (in tandem with Bicumulide first, and now Xtandi). Due to a recent increase in my PSA, I will soon begin Provenge treatment. I have no pain and have, from the
Hello, I have metastatic prostate cancer (bony metastases). Thus far, I have had 39 radiation treatments, have been on Lupron for over one year (in tandem with Bicumulide first, and now Xtandi). Due to a recent increase in my PSA, I will soon begin Provenge treatment. I have no pain and have, from the
N-Kitch
in
Advanced Prostate Cancer
7 years ago
ADT or Orchiectomy
Four months back the disease turned to
castration
resistant. My M.O has added zytiga. But I have to still continue Lupron injections. I am looking for the possibility of an Orchiectomy as an alternative for lupron injections to reduce my expenses. Is it a good decision?
Four months back the disease turned to
castration
resistant. My M.O has added zytiga. But I have to still continue Lupron injections. I am looking for the possibility of an Orchiectomy as an alternative for lupron injections to reduce my expenses. Is it a good decision?
dress2544
in
Advanced Prostate Cancer
7 years ago
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Phase II Study of Low-Dose Abiraterone With Food.
[Epub ahead of print] Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In
Castration
-Resistant Prostate Cancer.
[Epub ahead of print] Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In
Castration
-Resistant Prostate Cancer.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Issues New Guidelines for Optimizing Anticancer Therapy in Metastatic non-CRPC.
. - The appropriate regimen of abiraterone is 1,000 mg with either prednisolone or prednisone 5 mg once daily until treatment(s) for metastatic
castration
-resistant disease are initiated. - The panel noted that ADT plus docetaxel vs ADT plus abiraterone have not been compared, and it is unknown if some
. - The appropriate regimen of abiraterone is 1,000 mg with either prednisolone or prednisone 5 mg once daily until treatment(s) for metastatic
castration
-resistant disease are initiated. - The panel noted that ADT plus docetaxel vs ADT plus abiraterone have not been compared, and it is unknown if some
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Damned if you do/Damned if you don't....Old Expression with NEW meaning.
P.P.S. when I was describing the "joys of Lupron/
Castration
" to my chiropractor...he asked...but "how long do you have to do it?" ~~OY, when I said...not sure...but "as long as I live" is what it seems like...even he looked SAD ! ! !
P.P.S. when I was describing the "joys of Lupron/
Castration
" to my chiropractor...he asked...but "how long do you have to do it?" ~~OY, when I said...not sure...but "as long as I live" is what it seems like...even he looked SAD ! ! !
greatjohn
in
Advanced Prostate Cancer
6 years ago
A "Novel" CRPC Mechanism.
Persistence of intratumoral androgens has been found in
castration
-resistant prostate cancer and attributed to increased in situ synthesis. Recently, Sharifi and colleagues reported an additional mechanism that can enhance local androgenic exposure: downregulation of an androgen-inactivating enzyme.
Persistence of intratumoral androgens has been found in
castration
-resistant prostate cancer and attributed to increased in situ synthesis. Recently, Sharifi and colleagues reported an additional mechanism that can enhance local androgenic exposure: downregulation of an androgen-inactivating enzyme.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (Statin use & outcomes.)
{prednisone (P), abiraterone (AA)} -Patrick 230 Poster Session (Board #L6), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM Impact of statins on outcomes in patients (pts) with metastatic
castration
resistant prostate cancer (mCRPC): Post-hoc analysis of data from COU-AA-301 and COU-AA-302 trials.
{prednisone (P), abiraterone (AA)} -Patrick 230 Poster Session (Board #L6), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM Impact of statins on outcomes in patients (pts) with metastatic
castration
resistant prostate cancer (mCRPC): Post-hoc analysis of data from COU-AA-301 and COU-AA-302 trials.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
ASCO Genitourinary Cancers Symposium (Statins again)
-Patrick 277 Poster Session (Board #N9), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM Statin use and outcomes of patients (pts) with metastatic
castration
resistant prostate cancer (mCRPC) being treated with abiraterone (Abi). Jacob A Gordon, Bernhard J. Eigl, Jennifer A.
-Patrick 277 Poster Session (Board #N9), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM Statin use and outcomes of patients (pts) with metastatic
castration
resistant prostate cancer (mCRPC) being treated with abiraterone (Abi). Jacob A Gordon, Bernhard J. Eigl, Jennifer A.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Ralaniten [EPI-506]
Unfortunately, the clinical trial "Safety and Anti-Tumor Study of Oral EPI-506 for Patients With Metastatic
Castration
-Resistant Prostate Cancer" has been terminated: "At end of Phase 1 excessive high pill burden (18 capsules/day)" [3] 18 caps? Why, that's nothing to Nalakrats.
Unfortunately, the clinical trial "Safety and Anti-Tumor Study of Oral EPI-506 for Patients With Metastatic
Castration
-Resistant Prostate Cancer" has been terminated: "At end of Phase 1 excessive high pill burden (18 capsules/day)" [3] 18 caps? Why, that's nothing to Nalakrats.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Practical Guidance on the Role of Corticosteroids in the Treatment of Metastatic Castration-resistant Prostate Cancer
Good general information for reference regarding the use of corticosteroids in MCRPC https://www.sciencedirect.com/science/article/pii/S0090429516001461
Good general information for reference regarding the use of corticosteroids in MCRPC https://www.sciencedirect.com/science/article/pii/S0090429516001461
Hidden
in
Advanced Prostate Cancer
6 years ago
Quality of Life in Second-Line Treatment of Metastatic Castration-Resistant Prostate
Found a very interesting article on a trial done in Switzerland regarding quality of life in MCRPC patients who took different second-line treatments after ADT and Docetaxel chemotherapy. So many of the guidelines for second-line treatments I've found refer to "Chemotherapy-Naive" patients. Here, they
Found a very interesting article on a trial done in Switzerland regarding quality of life in MCRPC patients who took different second-line treatments after ADT and Docetaxel chemotherapy. So many of the guidelines for second-line treatments I've found refer to "Chemotherapy-Naive" patients. Here, they
Hidden
in
Advanced Prostate Cancer
6 years ago
Neutrophil-to-Lymphocyte ratio [NLR] & Abiraterone.
Baseline neutrophil-to-lymphocyte ratio predicts the prognosis of
castration
-resistant prostate cancer treated with abiraterone acetate. Yasui M1, Hasegawa Y2, Kawahara T1, Kumano Y1, Miyoshi Y1, Matsubara N2, Uemura H1.
Baseline neutrophil-to-lymphocyte ratio predicts the prognosis of
castration
-resistant prostate cancer treated with abiraterone acetate. Yasui M1, Hasegawa Y2, Kawahara T1, Kumano Y1, Miyoshi Y1, Matsubara N2, Uemura H1.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
I'm Struggling
Over the past 6 months (since chemo finished) my PSA has risen from 0.69 to 3.6 and my oncologist has confirmed
castration
resistance. I can handle this also. I have recently added Xtandi to the mix. The scary development has been progression in bony mets.
Over the past 6 months (since chemo finished) my PSA has risen from 0.69 to 3.6 and my oncologist has confirmed
castration
resistance. I can handle this also. I have recently added Xtandi to the mix. The scary development has been progression in bony mets.
paulofaus
in
Advanced Prostate Cancer
7 years ago
Vitamin K2.
I reviewed the literature a year ago in: "Foods/Supplements-Vitamins: Vitamin K" In the new study: "Vitamin K2, a menaquinone ... targets
castration
-resistant prostate cancer cell-line by activating apoptosis signaling."
I reviewed the literature a year ago in: "Foods/Supplements-Vitamins: Vitamin K" In the new study: "Vitamin K2, a menaquinone ... targets
castration
-resistant prostate cancer cell-line by activating apoptosis signaling."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Interesting result for BRCA patients from ASCO2018
"Effect of germline DNA repair gene mutations on outcomes in men with metastatic
castration
-resistant prostate cancer receiving first-line abiraterone and enzalutamide."
"Effect of germline DNA repair gene mutations on outcomes in men with metastatic
castration
-resistant prostate cancer receiving first-line abiraterone and enzalutamide."
snoraste
in
Advanced Prostate Cancer
7 years ago
ORCHIECTOMY OR ADT??
I have no hang up about
castration
since they have already done that with ADT. I do wonder if after surgery there is any improvement in the ADT symptoms. Is osteopenia a bigger concern long term if surgery is the method of
castration
? l
I have no hang up about
castration
since they have already done that with ADT. I do wonder if after surgery there is any improvement in the ADT symptoms. Is osteopenia a bigger concern long term if surgery is the method of
castration
? l
steinmother
in
Prostate Cancer Network
7 years ago
Quality of Life Follow up LATITUDE trial (Zytiga+Prednisone+ADT)
of the LATITUDE trial was designed to evaluate patient-reported outcomes with ADT plus abiraterone/prednisone or placebo in men with
castration
-naïve prostate cancer.
of the LATITUDE trial was designed to evaluate patient-reported outcomes with ADT plus abiraterone/prednisone or placebo in men with
castration
-naïve prostate cancer.
snoraste
in
Advanced Prostate Cancer
7 years ago
Long-term remission of prostate cancer with extensive bone metastases upon immuno- and virotherapy: A case report
In a phase III trial, following vaccination with activated autologous DC, a prolonged overall survival time was demonstrated in patients suffering from
castration
-resistant prostate cancer (4).
In a phase III trial, following vaccination with activated autologous DC, a prolonged overall survival time was demonstrated in patients suffering from
castration
-resistant prostate cancer (4).
JLS1
in
Advanced Prostate Cancer
6 years ago
Recent article about Lutetium 177 treatment in advanced mCRPC by doctors at the Technical University of Munich
Munich, Munich, Germany; Technical University of Munich, Munich, Germany Abstract Disclosures Background: To report our clinical experience with 177Lutetium-labeled prostate-specific membrane antigen-ligand (177Lu-PSMA-I&T) for systemic radioligand therapy in 100 consecutive patients with metastatic
castration
-resistant
Munich, Munich, Germany; Technical University of Munich, Munich, Germany Abstract Disclosures Background: To report our clinical experience with 177Lutetium-labeled prostate-specific membrane antigen-ligand (177Lu-PSMA-I&T) for systemic radioligand therapy in 100 consecutive patients with metastatic
castration
-resistant
Hidden
in
Advanced Prostate Cancer
6 years ago
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