Ralaniten [EPI-506]

[pjoshea13]

A new review [1] of anti-androgens mentions Ralaniten (aka EPI-506) as a:

"novel first-in-class drug ... which binds to a unique region in the N-terminus domain of both the full-length and the truncated constitutively active splice variants of the AR, {&} is currently in clinical trials for patients who previously received abiraterone, enzalutamide, or both."

i.e. could be useful with Zytiga/Xtandi resistance due to AR-V7.

(The only additional thing I can discover about it from PubMed is that it is derived from a sponge [2].)

Unfortunately, the clinical trial "Safety and Anti-Tumor Study of Oral EPI-506 for Patients With Metastatic Castration-Resistant Prostate Cancer" has been terminated:

"At end of Phase 1 excessive high pill burden (18 capsules/day)" [3]

18 caps? Why, that's nothing to Nalakrats. I've seen him take handfuls before, during & after lunch!

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/294...

[2] ncbi.nlm.nih.gov/pubmed/284...

[3] clinicaltrials.gov/ct2/show...

[gusgold]

You are right...nalakrats also takes a quart of Gator Blood a day...but it has not been without side effects...see latest pic of Nalakrats below

img15.deviantart.net/f8c6/i...

[j-o-h-n in reply to gusgold]

Problem Alert!!! He should have combined the Gator Blood with the dead dingo's donga sausages to clear up his skin.

Good Luck and Good Health.

j-o-h-n Sunday 03/04/2018 1:33 PM EST

[Dan59]

Patrick , Thank You for your always persistant posting of studies for us.