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Castration
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Have you repeated chemo so far in your journey?
Lupron, Docetaxel (worked very well), Surgical
Castration
..... after 3 months, PSA takes a significant jump. Now on Zytiga for 3 months, PSA better but unstable. After 14 months of these drugs and no testosterone, my physical body is not what it was when it all began.
Lupron, Docetaxel (worked very well), Surgical
Castration
..... after 3 months, PSA takes a significant jump. Now on Zytiga for 3 months, PSA better but unstable. After 14 months of these drugs and no testosterone, my physical body is not what it was when it all began.
TenscTexan
in
Advanced Prostate Cancer
6 years ago
Metastasis-free Survival - Enzalutamide.
We hypothesized that enzalutamide, which prolongs overall survival among patients with metastatic,
castration
-resistant prostate cancer, would delay metastasis in men with nonmetastatic,
castration
-resistant prostate cancer and a rapidly rising PSA level.
We hypothesized that enzalutamide, which prolongs overall survival among patients with metastatic,
castration
-resistant prostate cancer, would delay metastasis in men with nonmetastatic,
castration
-resistant prostate cancer and a rapidly rising PSA level.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Zytiga, Akt & PTEN.
Abstract PURPOSE: PI3K-Akt-mTOR and AR signaling are commonly aberrantly activated in metastatic
castration
-resistant prostate cancer (mCRPC), with PTEN loss associating with poor prognosis.
Abstract PURPOSE: PI3K-Akt-mTOR and AR signaling are commonly aberrantly activated in metastatic
castration
-resistant prostate cancer (mCRPC), with PTEN loss associating with poor prognosis.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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Are we jumping the gun here, can we see if Zytiga settles my PSA first before hitting me with Chemo Again?
In fear Lupron wasn't doing enough and knowing more cancer drugs would be coming, I had surgical
castration
in September.
In fear Lupron wasn't doing enough and knowing more cancer drugs would be coming, I had surgical
castration
in September.
TenscTexan
in
Advanced Prostate Cancer
6 years ago
[177Lu]-PSMA-617 Has Activity in Castration-Resistant Prostate Cancer
Patients with progressive metastatic
castration
-resistant prostate cancer have limited treatment options, and new therapeutic approaches are needed.
Patients with progressive metastatic
castration
-resistant prostate cancer have limited treatment options, and new therapeutic approaches are needed.
tango65
in
Advanced Prostate Cancer
6 years ago
Study Backs Warren Buffett Protocol On crMPCa
Looks like a DQ double cheeseburger - large fries - milk shake - Blizzard improves overall survival in late stage cancer..no longer do you have to eat tree bark like Eaul Gibbons and die of a bleeding ulcer https://prostatecancernewstoday.com/2018/05/21/obesity-linked-to-better-overall-survival-in-
castration
-resistant-prostate-cancer-study-shows
Looks like a DQ double cheeseburger - large fries - milk shake - Blizzard improves overall survival in late stage cancer..no longer do you have to eat tree bark like Eaul Gibbons and die of a bleeding ulcer https://prostatecancernewstoday.com/2018/05/21/obesity-linked-to-better-overall-survival-in-
castration
-resistant-prostate-cancer-study-shows
gusgold
in
Advanced Prostate Cancer
6 years ago
Enzalutamide Product info, FYI
I got the following info regarding Enzalutamide by email...I thought to post and share, just as an FYI MECHANISM OF ACTIONEnzalutamide is a second generation androgen receptor inhibitor INDICATIONEnzalutamide indicated for the treatment of patients with non-metastatic
castration
-resistant prostate
I got the following info regarding Enzalutamide by email...I thought to post and share, just as an FYI MECHANISM OF ACTIONEnzalutamide is a second generation androgen receptor inhibitor INDICATIONEnzalutamide indicated for the treatment of patients with non-metastatic
castration
-resistant prostate
Darryl
Partner
in
Advanced Prostate Cancer
6 years ago
Apalutamide product info, just an FYI
MECHANISM OF ACTIONApalutamide is a second generation androgen receptor inhibitor INDICATIONApalutamide indicated for the treatment of patients with non-metastatic
castration
-resistant prostate cancer.
MECHANISM OF ACTIONApalutamide is a second generation androgen receptor inhibitor INDICATIONApalutamide indicated for the treatment of patients with non-metastatic
castration
-resistant prostate cancer.
Darryl
Partner
in
Advanced Prostate Cancer
6 years ago
Phase 1b-2 Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant PC
Anyone have any experience with this clinical trial? If my PSA continues to increase my doctor is interested in my signing up for this. I’ve been on the Prednisone, Zytiga, Apalutemide Clinical trial for 16 months but, alas, the s.o.b. Is starting to win again. I’m treated at MD Anderson in Houston
Anyone have any experience with this clinical trial? If my PSA continues to increase my doctor is interested in my signing up for this. I’ve been on the Prednisone, Zytiga, Apalutemide Clinical trial for 16 months but, alas, the s.o.b. Is starting to win again. I’m treated at MD Anderson in Houston
scarlino
in
Advanced Prostate Cancer
6 years ago
EAU18 - Copenhagen. PROSPER Trial.
Prostate Cancer (nmCRPC) Prostate-Specific Antigen Response in Men with Nonmetastatic
Castration
-Resistant Prostate Cancer Treated with Enzalutamide: Results from PROSPER Watch: Meeting an Unmet Need in the Non-Metastatic
Castration
Resistant Prostate Cancer Patient Population - Maha Hussain Watch
Prostate Cancer (nmCRPC) Prostate-Specific Antigen Response in Men with Nonmetastatic
Castration
-Resistant Prostate Cancer Treated with Enzalutamide: Results from PROSPER Watch: Meeting an Unmet Need in the Non-Metastatic
Castration
Resistant Prostate Cancer Patient Population - Maha Hussain Watch
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Testosterone metabolites inhibit proliferation of castration- and therapy-resistant PCa.
KEYWORDS: 3a-androstendiol; 3b-androstendiol; AKR1C1; AKR1C2 and AKR1C3;
castration
resistant prostate cancer PMID: 29682196 PMCID: PMC5908297 DOI: 10.18632/oncotarget.24763
KEYWORDS: 3a-androstendiol; 3b-androstendiol; AKR1C1; AKR1C2 and AKR1C3;
castration
resistant prostate cancer PMID: 29682196 PMCID: PMC5908297 DOI: 10.18632/oncotarget.24763
pjoshea13
in
Advanced Prostate Cancer
6 years ago
18F-fluorodeoxyglucose PET
We also demonstrate that patients exhibiting a high IPFU had an increased risk of biochemical and
castration
resistance, thus revealing an aggressive behaviour of PCa foci with increased glucose uptake.
We also demonstrate that patients exhibiting a high IPFU had an increased risk of biochemical and
castration
resistance, thus revealing an aggressive behaviour of PCa foci with increased glucose uptake.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
EAU18 - Copenhagen. Castration Resistant PCa [CRPC]
Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre, twitter: @GoldbergHanan at the 2018 European Association of Urology Meeting EAU18, 16-20 March, 2018 Copenhagen, Denmark" -Patrick https://www.urotoday.com/conference-highlights/eau-2018/eau-2018-prostate-cancer/102991-eau-2018-
castration
-resistant-prostate-cancer.html
Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre, twitter: @GoldbergHanan at the 2018 European Association of Urology Meeting EAU18, 16-20 March, 2018 Copenhagen, Denmark" -Patrick https://www.urotoday.com/conference-highlights/eau-2018/eau-2018-prostate-cancer/102991-eau-2018-
castration
-resistant-prostate-cancer.html
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Trials NCT 03338790 or NCT02897375 Decided on NCT 03338790 trial
Anyone on either of this trials NCT 03338790 (An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic
Castration
-resistant Prostate Cancer (CheckMate 9KD)) or NCT02897375 (Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors
Anyone on either of this trials NCT 03338790 (An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic
Castration
-resistant Prostate Cancer (CheckMate 9KD)) or NCT02897375 (Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors
cjkn2000
in
Advanced Prostate Cancer
6 years ago
A Million Flaccid Men's March on Washington!
All of the generations of "real" men who have done this have done VERY little for the fight for an actual cure...or even BETTER treatment options...
Castration
as a treatment option sucks 10 MILLION times more than losing a boob.
All of the generations of "real" men who have done this have done VERY little for the fight for an actual cure...or even BETTER treatment options...
Castration
as a treatment option sucks 10 MILLION times more than losing a boob.
greatjohn
in
Advanced Prostate Cancer
6 years ago
IMAAGEN - Abiraterone Acetate & Prednisone in non-mCRPC.
Abstract PURPOSE: To evaluate the use of abiraterone acetate (1000 mg) plus prednisone (5mg) [AA+P] in patients with high-risk non-metastatic
castration
resistant prostate cancer (nmCRPC).
Abstract PURPOSE: To evaluate the use of abiraterone acetate (1000 mg) plus prednisone (5mg) [AA+P] in patients with high-risk non-metastatic
castration
resistant prostate cancer (nmCRPC).
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Yonsa vs Zytiga
In February 2018, Zytiga was approved in combination with prednisone for patients with metastatic high-risk
castration
-sensitive prostate cancer.
In February 2018, Zytiga was approved in combination with prednisone for patients with metastatic high-risk
castration
-sensitive prostate cancer.
JLS1
in
Advanced Prostate Cancer
6 years ago
Prostectomy possible after radiation
Now the disease is
castration
resistant and I am on zytiga + Prednisone. Last psa one month ago was 1.0. Latest psma pet scan showed the prostate gland and nearby organs are free of cancer. Even though there is cancer still in the iliac node, the size is not increased for the last two years.
Now the disease is
castration
resistant and I am on zytiga + Prednisone. Last psa one month ago was 1.0. Latest psma pet scan showed the prostate gland and nearby organs are free of cancer. Even though there is cancer still in the iliac node, the size is not increased for the last two years.
dress2544
in
Advanced Prostate Cancer
6 years ago
[177Lu]-PSMA-617 Radionuclide Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer
Nothing earth shattering - but worth a quick glimpse https://www.practiceupdate.com/c/67930/1/1/?elsca1=emc_enews_expert-insight&elsca2=email&elsca3=practiceupdate_onc&elsca4=oncology&elsca5=newsletter&rid=MzEwODYyNTk2NjA2S0&lid=10332481
Nothing earth shattering - but worth a quick glimpse https://www.practiceupdate.com/c/67930/1/1/?elsca1=emc_enews_expert-insight&elsca2=email&elsca3=practiceupdate_onc&elsca4=oncology&elsca5=newsletter&rid=MzEwODYyNTk2NjA2S0&lid=10332481
snoraste
in
Advanced Prostate Cancer
6 years ago
A year ago today, still waiting for some good news.
I asked if surgical
castration
would be an option to the Lupron, as maybe it wasn't working well on me, he said he wouldn't try to talk me out of it but it would have to wait until 6 weeks after chemo, so late September.
I asked if surgical
castration
would be an option to the Lupron, as maybe it wasn't working well on me, he said he wouldn't try to talk me out of it but it would have to wait until 6 weeks after chemo, so late September.
TenscTexan
in
Advanced Prostate Cancer
6 years ago
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