Search
Search
About
Log in
Join
Experiences with
Castration
Posts
Communities
1,150 public posts
Filter results
high dose testosterone and androgen receptors
Small sample, no longer term follow up but interesting. http://abstracts.asco.org/239/AbstView_239_270633.html "AR changes in circulating-tumor DNA (ctDNA) in patients with metastatic
castration
-resistant prostate cancer (mCRPC) treated with high-dose testosterone.
Small sample, no longer term follow up but interesting. http://abstracts.asco.org/239/AbstView_239_270633.html "AR changes in circulating-tumor DNA (ctDNA) in patients with metastatic
castration
-resistant prostate cancer (mCRPC) treated with high-dose testosterone.
kaptank
in
Advanced Prostate Cancer
5 years ago
Apalutamide Submitted to FDA for Treatment of Metastatic Castration-Sensitive Prostate Cancer
https://www.targetedonc.com/news/apalutamide-submitted-to-fda-for-treatment-of-metastatic-castrationsensitive-prostate-cancer
https://www.targetedonc.com/news/apalutamide-submitted-to-fda-for-treatment-of-metastatic-castrationsensitive-prostate-cancer
Longterm101
in
Advanced Prostate Cancer
5 years ago
New Drug BAY1841788 (ODM-201) has been successful for CRPC patients, Clinical trial Phase III completed.
This drug is for patients with
Castration
Resistance Prostate Cancer , apparently the clinical trial (NCT02200614) was completed on September 3, 2018, and was successful. Increases the life expectancy from 18.4 to 40.4.
This drug is for patients with
Castration
Resistance Prostate Cancer , apparently the clinical trial (NCT02200614) was completed on September 3, 2018, and was successful. Increases the life expectancy from 18.4 to 40.4.
bboby
in
Advanced Prostate Cancer
5 years ago
Want to take advantage of all our features? Just log in!
Log in
or
Join
asking for members' input
I do not like the idea of just staying on ADT and waiting for
castration
resistance. His oncologist is willing to go straight to abiraterone (I understand there is no evidence for this, but it seems like a sensible thing to do. What do you guys think?
I do not like the idea of just staying on ADT and waiting for
castration
resistance. His oncologist is willing to go straight to abiraterone (I understand there is no evidence for this, but it seems like a sensible thing to do. What do you guys think?
mediocra
in
Advanced Prostate Cancer
5 years ago
Overturning Dogma -- Using Testosterone in Prostate Cancer
The concern has been that testosterone will accelerate the growth of prostate cancer cells, and indeed, usual treatment aims to lower testosterone levels with "chemical
castration
" using androgen deprivation therapy.
The concern has been that testosterone will accelerate the growth of prostate cancer cells, and indeed, usual treatment aims to lower testosterone levels with "chemical
castration
" using androgen deprivation therapy.
kryciakrycia
in
Advanced Prostate Cancer
5 years ago
Local ablative radiotherapy: A means to revert low volume castration-resistant prostate cancer into a hormone-sensitive status?
Sounds promising. These patients had a PSADT of 3.2 months before RT. After RT, it took 15.6 months for the PSA to increase from nadir to nadir+2. Looking forward to the prospective study. ---------- https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.6_suppl.188 --------- Conclusions: A relevant subset
Sounds promising. These patients had a PSADT of 3.2 months before RT. After RT, it took 15.6 months for the PSA to increase from nadir to nadir+2. Looking forward to the prospective study. ---------- https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.6_suppl.188 --------- Conclusions: A relevant subset
tango65
in
Advanced Prostate Cancer
5 years ago
Has anyone seen testosterone rise on xtandi while still on lupron?
After starting xtandi 3 months ago due to developing
castration
resistance, my T has risen to 63 which is above castrate level. Not sure if it's worth staying on 3 month eligard shot if it's not keeping me below castrate level. Xtandi has been very good at lowering Psa, now undetectable
After starting xtandi 3 months ago due to developing
castration
resistance, my T has risen to 63 which is above castrate level. Not sure if it's worth staying on 3 month eligard shot if it's not keeping me below castrate level. Xtandi has been very good at lowering Psa, now undetectable
joeguy
in
Advanced Prostate Cancer
5 years ago
LATITUDE - Final report.
-Patrick [1] https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30082-8/fulltext#%20
Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic
-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind
-Patrick [1] https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30082-8/fulltext#%20
Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic
-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind
pjoshea13
in
Advanced Prostate Cancer
5 years ago
TP53 Outperforms Other Androgen Receptor Biomarkers to Predict Outcomes With Abiraterone or Enzalutamide in mCRPC
TAKE-HOME MESSAGE Precision targeting within the androgen signaling pathway remains critical in the care of patients with metastatic
castration
-resistant prostate cancer (mCRPC).
TAKE-HOME MESSAGE Precision targeting within the androgen signaling pathway remains critical in the care of patients with metastatic
castration
-resistant prostate cancer (mCRPC).
tango65
in
Advanced Prostate Cancer
5 years ago
Zitga needed?
Sytiga is aimed at
castration
resistant tumors and the mets disappeared since Dec 17. (hurray) Zytiga is killing my energy! Thanks
Sytiga is aimed at
castration
resistant tumors and the mets disappeared since Dec 17. (hurray) Zytiga is killing my energy! Thanks
sandbergc9
in
Advanced Prostate Cancer
5 years ago
Adrenal androgens rescue prostatic dihydrotestosterone production and growth of prostate cancer cells after castration.
[Epub ahead of print]
Adrenal androgens rescue prostatic dihydrotestosterone production and growth of prostate cancer cells after
. Wu Y1, Tang L2, Azabdaftari G3, Pop E4, Smith GJ4.
[Epub ahead of print]
Adrenal androgens rescue prostatic dihydrotestosterone production and growth of prostate cancer cells after
. Wu Y1, Tang L2, Azabdaftari G3, Pop E4, Smith GJ4.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Does this make sense?
Given the functional roles of FKBP52 in receptor-specific phenotypes, and its direct participation in the aberrant AR hyperactivity observed in prostate cancer, FKBP52 has emerged as a novel therapeutic target with the potential to treat
castration
-resistant prostate cancer, thereby filling a major unmet
Given the functional roles of FKBP52 in receptor-specific phenotypes, and its direct participation in the aberrant AR hyperactivity observed in prostate cancer, FKBP52 has emerged as a novel therapeutic target with the potential to treat
castration
-resistant prostate cancer, thereby filling a major unmet
cesanon
in
Advanced Prostate Cancer
5 years ago
Exceptional Response to 177-Lutetium PSMA in Prostate Cancer Harboring DNA Repair Defects
New phase II result : "This case study reports an exceptional response to 177lutetium PSMA in a patient with metastatic
castration
-resistant prostate cancer with DNA repair defects, including frameshift mutation in exon 11 of the BRCA2 gene." https://www.practiceupdate.com/C/79795/56?
New phase II result : "This case study reports an exceptional response to 177lutetium PSMA in a patient with metastatic
castration
-resistant prostate cancer with DNA repair defects, including frameshift mutation in exon 11 of the BRCA2 gene." https://www.practiceupdate.com/C/79795/56?
snoraste
in
Advanced Prostate Cancer
5 years ago
Prednisone to Blame for ERA 223 Trial Failure?
"The ERA 223 trial was a randomized phase 3 study that enrolled 806 men with asymptomatic or mildly symptomatic men with chemotherapy-naïve
castration
-resistant prostate cancer (CRPC) and bone metastases (more than 2 bone metastatic lesions).
"The ERA 223 trial was a randomized phase 3 study that enrolled 806 men with asymptomatic or mildly symptomatic men with chemotherapy-naïve
castration
-resistant prostate cancer (CRPC) and bone metastases (more than 2 bone metastatic lesions).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Not rising psa
https://www.targetedonc.com/publications/ targeted-therapies-cancer/2018/2018-april/dramatic-response-to-olaparib-in-a-patient-with-metastatic-
castration
-resistant-prostate-cancer
https://www.targetedonc.com/publications/ targeted-therapies-cancer/2018/2018-april/dramatic-response-to-olaparib-in-a-patient-with-metastatic-
castration
-resistant-prostate-cancer
Annie1373
in
Advanced Prostate Cancer
5 years ago
Casodex & metformin
First enrolled 42 patients with
castration
resistant prostate cancer who were treated with metformin, 1,000 mg twice daily. Two patients had ≥ 50% PSA decline and in 23 patients (52.3%) had a prolongation of PSA doubling time.
First enrolled 42 patients with
castration
resistant prostate cancer who were treated with metformin, 1,000 mg twice daily. Two patients had ≥ 50% PSA decline and in 23 patients (52.3%) had a prolongation of PSA doubling time.
Ahk1
in
Advanced Prostate Cancer
5 years ago
Chemotherapy with ADT & Radiotherapy for Localized High-Risk PCa.
with metastatic disease.8 Taken together, these studies suggest that there is a positive effect of docetaxel CT in subsets of men with
castration
-sensitive prostate cancer but reinforce the need for improved patient selection to better define these subsets.
with metastatic disease.8 Taken together, these studies suggest that there is a positive effect of docetaxel CT in subsets of men with
castration
-sensitive prostate cancer but reinforce the need for improved patient selection to better define these subsets.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Real World Effectiveness of Docetaxel for Castration Sensitive Prostate Cancer
https://www.practiceupdate.com/C/78589/56?elsca1=emc_enews_topic-alert
https://www.practiceupdate.com/C/78589/56?elsca1=emc_enews_topic-alert
Balsam01
in
Advanced Prostate Cancer
6 years ago
Becoming castration resistance or not?
My question is this why his psa decreasing slowly as compared to april'18 Is he slowly becoming
castration
resistant. Why the response is slow .
My question is this why his psa decreasing slowly as compared to april'18 Is he slowly becoming
castration
resistant. Why the response is slow .
Hidden
in
Advanced Prostate Cancer
6 years ago
Advanced prostate cancer and Low Hb.
How his psa responding to hormone therapy Is he getting
castration
resistance?
How his psa responding to hormone therapy Is he getting
castration
resistance?
Hidden
in
Advanced Prostate Cancer
6 years ago
1
...
42
43
44
...
58
Next page
10
20
30
40
50
Filter results
Clear filters
Posted in
All communities
Advanced Prostate Cancer
1024 results
Fight Prostate Cancer
70 results
Prostate Cancer Network
25 results
View top 10 communities
Sort by
Most Relevant
Newest