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Local Ablative Radiotherapy Reverts CRPC to Earlier Disease Stage
elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=MjE1MTA5NDQ5Nzg2S0&lid=10332481 After radiation 73% of the 15 patients analysed had a decreased PSA value in spite of being
castration
resistant. 6 patients got
elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=MjE1MTA5NDQ5Nzg2S0&lid=10332481 After radiation 73% of the 15 patients analysed had a decreased PSA value in spite of being
castration
resistant. 6 patients got
GP24
in
Advanced Prostate Cancer
5 years ago
Enzalutamide & Abiraterone ... higher T = more favorable prognosis.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and Abiraterone-Treated
Castration
-Resistant Prostate Cancer.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and Abiraterone-Treated
Castration
-Resistant Prostate Cancer.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Local Ablative Radiotherapy Reverts CRPC to Earlier Disease Stage
European Association of Urology Can Local Ablative Radiotherapy Revert
Castration
-Resistant Prostate Cancer to an Earlier Stage of Disease?
European Association of Urology Can Local Ablative Radiotherapy Revert
Castration
-Resistant Prostate Cancer to an Earlier Stage of Disease?
Balsam01
in
Advanced Prostate Cancer
5 years ago
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Clinical Utility of CTC AR-V7 Status in mCRPC
PATIENT SUMMARY Liquid biopsies that determine circulating tumour cell androgen receptor splice variant-7 status have the potential to impact treatment decisions in metastatic
castration
-resistant prostate cancer patients.
PATIENT SUMMARY Liquid biopsies that determine circulating tumour cell androgen receptor splice variant-7 status have the potential to impact treatment decisions in metastatic
castration
-resistant prostate cancer patients.
Balsam01
in
Advanced Prostate Cancer
5 years ago
AR-V7 and Circulating Tumor Cell DNA Testing - Availability and Use
I am also considering initiating therapy with the next treatment before
castration
resistance fully develops (please see evolutionary and game theory posts by fellow members on this forum, highly recommended).
I am also considering initiating therapy with the next treatment before
castration
resistance fully develops (please see evolutionary and game theory posts by fellow members on this forum, highly recommended).
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
3 Years Post Diagnosis.
About 6 months later (1.5 years after diagnosis) my PSA tarted to rise rapidly whilst o Zoladex and I was declared '
castration
resistant'.
About 6 months later (1.5 years after diagnosis) my PSA tarted to rise rapidly whilst o Zoladex and I was declared '
castration
resistant'.
paulofaus
in
Advanced Prostate Cancer
5 years ago
Periprostatic Fat & ADT
The connection between androgen deprivation therapy, obesity, inflammation, and prostate cancer progression is well-established in clinical settings; however, an understanding of the changes in adipose tissue at the molecular level induced by
castration
therapies is missing.
The connection between androgen deprivation therapy, obesity, inflammation, and prostate cancer progression is well-established in clinical settings; however, an understanding of the changes in adipose tissue at the molecular level induced by
castration
therapies is missing.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in
Castration
-Resistant Prostate Cancer Bryden Considine, DODaniel P.
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in
Castration
-Resistant Prostate Cancer Bryden Considine, DODaniel P.
JLS1
in
Advanced Prostate Cancer
5 years ago
T levels and Zytiga
My understanding is that 50 ng/dl is considered
castration
level, but with prostate cancer you really want to try to get it under 20. My test came back at "<7", which means I don't have enough T for the test to detect.
My understanding is that 50 ng/dl is considered
castration
level, but with prostate cancer you really want to try to get it under 20. My test came back at "<7", which means I don't have enough T for the test to detect.
tom67inMA
in
Advanced Prostate Cancer
5 years ago
Has anyone done docetaxel with ADT as a first line treatment?
Also, are there any trials or studies right now for using these drugs prior to demonstrated
castration
-resistance?
Also, are there any trials or studies right now for using these drugs prior to demonstrated
castration
-resistance?
CantChoose
in
Advanced Prostate Cancer
5 years ago
Metastatic Castration-Sensitive Prostate Cancer: Optimizing Patient Selection and Treatment
https://ascopubs.org/doi/full/10.1200/EDBK_200967 Thought this was the best summary I've read yet. Has all the trials and medications.
https://ascopubs.org/doi/full/10.1200/EDBK_200967 Thought this was the best summary I've read yet. Has all the trials and medications.
CantChoose
in
Advanced Prostate Cancer
5 years ago
Two Paid Research Opportunities $1025 for Chicago residents and $100 for anywhere by phone
Two Paid Research Opportunities $1025 for Chicago residents and $100 for anywhere by phone Patients with a diagnosis of metastatic prostate cancer who have not been told they are
castration
-resistant, are needed to participate in a 60-minute phone interview using a computer at the end of May.
Two Paid Research Opportunities $1025 for Chicago residents and $100 for anywhere by phone Patients with a diagnosis of metastatic prostate cancer who have not been told they are
castration
-resistant, are needed to participate in a 60-minute phone interview using a computer at the end of May.
Darryl
Partner
in
Advanced Prostate Cancer
5 years ago
TAT-11: Expanding the Horizon of Targeted Alpha Therapy with Thorium Conjugates
Bayer currently has Xofigo, a drug using Radium-223(Cl2) approved in 54 countries for the treatment of patients with
castration
-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
Bayer currently has Xofigo, a drug using Radium-223(Cl2) approved in 54 countries for the treatment of patients with
castration
-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
tango65
in
Advanced Prostate Cancer
5 years ago
Simvastatin delays CRPC metastasis and AR antagonist resistance by regulating the expression of caveolin‑1.
Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of
castration
‑resistant prostate cancer (CRPC).
Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of
castration
‑resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
AUA 2019: PCa Papers
AUA 2019: Impact of Bone-Targeted Therapies in Patients with Chemotherapy-Naïve Metastatic
Castration
-Resistance Prostate Cancer on Enzalutamide: Post Hoc Analysis of PREVAIL AUA 2019: Low Free Testosterone is an Independent Risk Factor for High Grade Prostate Cancer AUA 2019: Decipher Biopsy Genomic
AUA 2019: Impact of Bone-Targeted Therapies in Patients with Chemotherapy-Naïve Metastatic
Castration
-Resistance Prostate Cancer on Enzalutamide: Post Hoc Analysis of PREVAIL AUA 2019: Low Free Testosterone is an Independent Risk Factor for High Grade Prostate Cancer AUA 2019: Decipher Biopsy Genomic
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Abiraterone Acetate Plus Prednisone in Newly Diagnosed High-Risk Metastatic Castration-Sensitive Prostate Cancer: Final OS Results
The Lancet Oncology Abiraterone Acetate Plus Prednisone in Patients With Newly Diagnosed High-Risk Metastatic
Castration
-Sensitive Prostate Cancer (LATITUDE): Final Overall Survival Analysis of a Randomised, Double-Blind, Phase 3 Trial Lancet Oncol 2019 Apr 12;[EPub Ahead of Print], K Fizazi, N Tran
The Lancet Oncology Abiraterone Acetate Plus Prednisone in Patients With Newly Diagnosed High-Risk Metastatic
Castration
-Sensitive Prostate Cancer (LATITUDE): Final Overall Survival Analysis of a Randomised, Double-Blind, Phase 3 Trial Lancet Oncol 2019 Apr 12;[EPub Ahead of Print], K Fizazi, N Tran
Balsam01
in
Advanced Prostate Cancer
5 years ago
Has anyone had a CTC Circulating Tumor Blood Test (CTC) for prostate cancer ? CELLSEARCH
These patients are commonly described as having androgen-independent, hormone-resistant, or
castration
-resistant prostate cancer.
These patients are commonly described as having androgen-independent, hormone-resistant, or
castration
-resistant prostate cancer.
Longterm101
in
Advanced Prostate Cancer
5 years ago
Abiraterone Acetate Plus Prednisone in Newly Diagnosed High-Risk Metastatic Castration-Sensitive Prostate Cancer
The Lancet Oncology Abiraterone Acetate Plus Prednisone in Patients With Newly Diagnosed High-Risk Metastatic
Castration
-Sensitive Prostate Cancer (LATITUDE): Final Overall Survival Analysis of a Randomised, Double-Blind, Phase 3 Trial Lancet Oncol 2019 Apr 12;[EPub Ahead of Print], K Fizazi, N Tran
The Lancet Oncology Abiraterone Acetate Plus Prednisone in Patients With Newly Diagnosed High-Risk Metastatic
Castration
-Sensitive Prostate Cancer (LATITUDE): Final Overall Survival Analysis of a Randomised, Double-Blind, Phase 3 Trial Lancet Oncol 2019 Apr 12;[EPub Ahead of Print], K Fizazi, N Tran
Balsam01
in
Advanced Prostate Cancer
5 years ago
Metformin?
Is anyone here with metastatic stage 4 hormone naive (not yet
castration
resistant) PCa taking Metformin, in addition to ADT (Lupron or Eligard or degarelix)? If so what are your observations regarding effectiveness? Thank-you.
Is anyone here with metastatic stage 4 hormone naive (not yet
castration
resistant) PCa taking Metformin, in addition to ADT (Lupron or Eligard or degarelix)? If so what are your observations regarding effectiveness? Thank-you.
6357axbz
in
Advanced Prostate Cancer
5 years ago
Veteran looking for some correct guidance and help !
My local Doctor suggested I go back to the VA and the next step is a Chemical
Castration
. I don't trust the VA anymore & looking for alternatives and suggestion's. Many Thanks Jack
My local Doctor suggested I go back to the VA and the next step is a Chemical
Castration
. I don't trust the VA anymore & looking for alternatives and suggestion's. Many Thanks Jack
Coleman53
in
Advanced Prostate Cancer
5 years ago
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