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Bipolar Androgen Therapy [BAT] & CRPC - Sam Denmeade, Hopkins.
They barely reach
castration
before the next T shot. "
SUO 2019: Bipolar Androgen Therapy for Men with
Resistant Prostate Cancer Washington, DC (UroToday.com) As part of the SUO 2019 advanced prostate cancer session, Dr.
They barely reach
castration
before the next T shot. "
SUO 2019: Bipolar Androgen Therapy for Men with
Resistant Prostate Cancer Washington, DC (UroToday.com) As part of the SUO 2019 advanced prostate cancer session, Dr.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate Cancer.
Author information Erratum in Correction: Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in
Castration
-Resistant Prostate Cancer.
Author information Erratum in Correction: Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in
Castration
-Resistant Prostate Cancer.
JLS1
in
Advanced Prostate Cancer
4 years ago
Sulfasalazine improves the anti cancer effect of Vitamin C in prostate cancer
prostate cancer cells via a glutathione-dependent mechanism Zijie Zheng, Ganhua Luo, Xinchong Shi, Yali Long, Wanqing Shen, Zhoulei Li & Xiangsong Zhang Cellular Oncology volume 43, pages95–106(2020)Cite this article Abstract Traditional treatment regimens for advanced prostate cancer, especially
castration
-resistant
prostate cancer cells via a glutathione-dependent mechanism Zijie Zheng, Ganhua Luo, Xinchong Shi, Yali Long, Wanqing Shen, Zhoulei Li & Xiangsong Zhang Cellular Oncology volume 43, pages95–106(2020)Cite this article Abstract Traditional treatment regimens for advanced prostate cancer, especially
castration
-resistant
Graham49
in
Advanced Prostate Cancer
4 years ago
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Can melatonin control AR amplification and therefore help mCRPC drugs work better and longer?
Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in
Castration
-Resistant Prostate Cancer (CRPC) Therapy https://www.ncbi.nlm.nih.gov
Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in
Castration
-Resistant Prostate Cancer (CRPC) Therapy https://www.ncbi.nlm.nih.gov
JLS1
in
Advanced Prostate Cancer
4 years ago
The Thymus.
"The atrophy is due to the increased circulating level of sex hormones, and chemical or physical
castration
of an adult results in the thymus increasing in size and activity." When I became aware of this, I wondered what the implications were for men on ADT.
"The atrophy is due to the increased circulating level of sex hormones, and chemical or physical
castration
of an adult results in the thymus increasing in size and activity." When I became aware of this, I wondered what the implications were for men on ADT.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Presentations at the 20th Annual Meeting of the Society of Urologic Oncology (SUO), Dec 04 - 06, 2019 in Washington DC.
start=0
SUO 2019 Prostate Cancer
SUO 2019: Bipolar AR Therapy SUO 2019: Bipolar Androgen Therapy for Men with
Castration
Resistant Prostate Cancer SUO 2019: Optimal Management of Metastatic
Castration
Sensitive Prostate Cancer SUO 2019: PARP Inhibitors for Prostate Cancer SUO 2019: Implementation
start=0
SUO 2019 Prostate Cancer
SUO 2019: Bipolar AR Therapy SUO 2019: Bipolar Androgen Therapy for Men with
Castration
Resistant Prostate Cancer SUO 2019: Optimal Management of Metastatic
Castration
Sensitive Prostate Cancer SUO 2019: PARP Inhibitors for Prostate Cancer SUO 2019: Implementation
pjoshea13
in
Advanced Prostate Cancer
5 years ago
CRPC & Transdermal Estrogen
Corticosteroids and estrogens are also useful agents in
castration
-resistant prostate cancer (CRPC). However, oral estrogens are associated with thromboembolic events, which limits their use, and transdermal estrogens may offer a safer alternative.
Corticosteroids and estrogens are also useful agents in
castration
-resistant prostate cancer (CRPC). However, oral estrogens are associated with thromboembolic events, which limits their use, and transdermal estrogens may offer a safer alternative.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
PSMA in circulating tumor cells is a new poor prognostic marker for castration-resistant PCa - Plos One - Published: January 27, 2020
However, most patients eventually progress to
castration
-resistant prostate cancer (CRPC), which is then treated with sequential therapy [1].
However, most patients eventually progress to
castration
-resistant prostate cancer (CRPC), which is then treated with sequential therapy [1].
cujoe
in
Fight Prostate Cancer
4 years ago
Xtandi from herbsandmeds.com
My cancer is now
castration
resistent and I went to Finland for a PET.scan for Lu-177 treatment three weeks ago and they told me I was suitable for the treatment. The doctor also told me I should take Xtandi during lutetium treatment.
My cancer is now
castration
resistent and I went to Finland for a PET.scan for Lu-177 treatment three weeks ago and they told me I was suitable for the treatment. The doctor also told me I should take Xtandi during lutetium treatment.
Axolotl2
in
Advanced Prostate Cancer
5 years ago
Luteolin & Androgen Receptor splice variant 7 [AR-V7].
MiR-8080 induced by luteolin intake enhanced the therapeutic effect of enzalutamide on 22Rv1 xenografts under
castration
conditions.
MiR-8080 induced by luteolin intake enhanced the therapeutic effect of enzalutamide on 22Rv1 xenografts under
castration
conditions.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Surgical Versus Medical Castration.
CONCLUSION: In a contemporary, real-world cohort, use of surgical
castration
is low and decreasing despite its potential advantages and similar survival compared to medical
castration
.
CONCLUSION: In a contemporary, real-world cohort, use of surgical
castration
is low and decreasing despite its potential advantages and similar survival compared to medical
castration
.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Prognostic Nutritional Index (PNI)
There is also another earlier 2017 paper, for advance PCa titled: "Prognostic nutritional index predicts initial response to treatment and prognosis in metastatic
castration
‐resistant prostate cancer patients treated with abiraterone". https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.23381
There is also another earlier 2017 paper, for advance PCa titled: "Prognostic nutritional index predicts initial response to treatment and prognosis in metastatic
castration
‐resistant prostate cancer patients treated with abiraterone". https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.23381
Hidden
in
Advanced Prostate Cancer
4 years ago
Dr says Enzalutimide... what about Cabazitaxel?
My thinking was inspired by this recent study (https://www.ncbi.nlm.nih.gov/pubmed/31566937) "CONCLUSIONS: Cabazitaxel significantly improved a number of clinical outcomes, as compared with the androgen-signaling-targeted inhibitor (abiraterone or enzalutamide), in patients with metastatic
castration
-resistant
My thinking was inspired by this recent study (https://www.ncbi.nlm.nih.gov/pubmed/31566937) "CONCLUSIONS: Cabazitaxel significantly improved a number of clinical outcomes, as compared with the androgen-signaling-targeted inhibitor (abiraterone or enzalutamide), in patients with metastatic
castration
-resistant
Tak-Druk
in
Advanced Prostate Cancer
4 years ago
Nadir - variation prior to castration resistance
Once one reaches their PSA nadir on ADT what is the expected variation in PSA readings while still
castration
sensitive?
Once one reaches their PSA nadir on ADT what is the expected variation in PSA readings while still
castration
sensitive?
6357axbz
in
Advanced Prostate Cancer
5 years ago
PSMA avid or not
At the time he was
castration
positive, I’m wondering if PSMA is changed when you become castrate resistant or if once your identified as PSMA avid you will always be PSMA avid? Does anyone know of data on this? Thanks!
At the time he was
castration
positive, I’m wondering if PSMA is changed when you become castrate resistant or if once your identified as PSMA avid you will always be PSMA avid? Does anyone know of data on this? Thanks!
Blair77
in
Advanced Prostate Cancer
5 years ago
Exceptional Response to Pembrolizumab in a Patient With Castration-Resistant Prostate Cancer With Pancytopenia From Myelophthisis: A Case Re
Metastatic
castration
-resistant prostate cancer (CRPC) remains lethal despite recent therapeutic advances. Although a survival benefit led to the U.S.
Metastatic
castration
-resistant prostate cancer (CRPC) remains lethal despite recent therapeutic advances. Although a survival benefit led to the U.S.
JLS1
in
Advanced Prostate Cancer
5 years ago
Clinical Trials Using Disulfiram
Copper Chloride, Disulfiram and Copper Gluconate in Treating Patients with Metastatic
Castration
-Resistant Prostate Cancer.... I found several articles on the subject on the internet.What is your opinion on this topic, did any of you try?
Copper Chloride, Disulfiram and Copper Gluconate in Treating Patients with Metastatic
Castration
-Resistant Prostate Cancer.... I found several articles on the subject on the internet.What is your opinion on this topic, did any of you try?
donits
in
Advanced Prostate Cancer
5 years ago
"HOW ENDOMETRIOSIS IS TACKLED BY THE MEDICAL COMMUNITY" TIMELINE
The current paradigm in endometriosis assumes endometriosis is chronic, that it will always return, and worse... it’s managed with denial, delays, drugs (that don’t eliminate disease or prevent progression),
castration
(chemical,or surgical) and ineffective ablation (burning the top of the lesion) and
The current paradigm in endometriosis assumes endometriosis is chronic, that it will always return, and worse... it’s managed with denial, delays, drugs (that don’t eliminate disease or prevent progression),
castration
(chemical,or surgical) and ineffective ablation (burning the top of the lesion) and
StefaniaJW
in
Endometriosis UK
5 years ago
more possibilities after exhausting SOC?: Enzalutamide-resistant castration-resistant prostate cancer: challenges and solutions
Published online 2018 Oct 24. doi: 10.2147/OTT.S153764 PMCID: PMC6204864 PMID: 30425524 Enzalutamide-resistant
castration
-resistant prostate cancer: challenges and solutions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204864/ "AR amplification and overexpression Up to 80% of CRPC patients show AR
Published online 2018 Oct 24. doi: 10.2147/OTT.S153764 PMCID: PMC6204864 PMID: 30425524 Enzalutamide-resistant
castration
-resistant prostate cancer: challenges and solutions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204864/ "AR amplification and overexpression Up to 80% of CRPC patients show AR
JLS1
in
Advanced Prostate Cancer
4 years ago
HCA, does it make any sense?
Many ACLY inhibitors were developed as anti-cancer agents." (2018) [4] c) "Targeting ACLY sensitizes
castration
-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism...
Many ACLY inhibitors were developed as anti-cancer agents." (2018) [4] c) "Targeting ACLY sensitizes
castration
-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism...
Hidden
in
Prostate Cancer Network
4 years ago
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