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Survival Outcomes for Sequential Use of New Agents in Metastatic Castration-Resistant Prostate Cancer
TAKE-HOME MESSAGE •Although there are many new treatments for metastatic
castration
-resistant prostate cancer (MCRPC), including cabazitaxel, enzalutamide, and abiraterone, the optimal sequence is poorly understood.
TAKE-HOME MESSAGE •Although there are many new treatments for metastatic
castration
-resistant prostate cancer (MCRPC), including cabazitaxel, enzalutamide, and abiraterone, the optimal sequence is poorly understood.
Balsam01
in
Advanced Prostate Cancer
4 years ago
Stopping Casodex before stopping Lupron
The hormone therapy is medical
castration
and hence will bring your testosterone down. In addition, your PSA has responded appropriately."
The hormone therapy is medical
castration
and hence will bring your testosterone down. In addition, your PSA has responded appropriately."
SooHwa99
in
Advanced Prostate Cancer
4 years ago
Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer
•Depending on gene alterations, rucaparib may be of some benefit to patients with metastatic
castration
-resistant prostate cancer.
•Depending on gene alterations, rucaparib may be of some benefit to patients with metastatic
castration
-resistant prostate cancer.
Balsam01
in
Advanced Prostate Cancer
4 years ago
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Combination of Statin/Vitamin D and Metastatic Castration-Resistant Prostate Cancer (CRPC) ...
Keywords: Abiraterone;
Castration
-resistant prostate cancer; Statins; Survival; Vitamin D.
Keywords: Abiraterone;
Castration
-resistant prostate cancer; Statins; Survival; Vitamin D.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Published in Oncology News · March 20, 2020 HOPA 2020: Metformin Shows Signs of Benefit in Metastatic Prostate Cancer
Patients were known to suffer from either metastatic hormone-sensitive (n = 205; 73.2%) or metastatic
castration
-resistant (n = 75; 26.8%) prostate cancer. Overall, 66 patients took metformin (23.5%); 215 did not (76.5%).
Patients were known to suffer from either metastatic hormone-sensitive (n = 205; 73.2%) or metastatic
castration
-resistant (n = 75; 26.8%) prostate cancer. Overall, 66 patients took metformin (23.5%); 215 did not (76.5%).
Balsam01
in
Advanced Prostate Cancer
4 years ago
CCW702 - FDA clears its IND for new immunotherapeutic for treating prostate cancer Aug 21 2019
First-in-human Study of CCW702 in Patients With Metastatic
Castration
Resistant Prostate Cancer https://www.clinicaltrials.gov/ct2/show/NCT04077021 Looks like it hasn't started yet?
First-in-human Study of CCW702 in Patients With Metastatic
Castration
Resistant Prostate Cancer https://www.clinicaltrials.gov/ct2/show/NCT04077021 Looks like it hasn't started yet?
JLS1
in
Advanced Prostate Cancer
4 years ago
Liver Function Abnormalities Rare in Men With Metastatic Prostate Cancer Treated With Abiraterone Acetate
BACKGROUND Abiraterone acetate (abiraterone) combined with prednisone is a standard of care in metastatic
castration
-resistant prostate cancer.
BACKGROUND Abiraterone acetate (abiraterone) combined with prednisone is a standard of care in metastatic
castration
-resistant prostate cancer.
TNCanuck
in
Advanced Prostate Cancer
4 years ago
Survival Outcomes for Sequential Use of New Agents in Metastatic Castration-Resistant Prostate Cancer
Johnson, MD INTRODUCTION The sequential use of a number of new agents (NAs) have improved the overall survival (OS) of patients with metastatic
castration
-resistant prostate cancer whose disease progresses after docetaxel (DOC) treatment.
Johnson, MD INTRODUCTION The sequential use of a number of new agents (NAs) have improved the overall survival (OS) of patients with metastatic
castration
-resistant prostate cancer whose disease progresses after docetaxel (DOC) treatment.
TNCanuck
in
Advanced Prostate Cancer
4 years ago
Recent 2020 research report, and one in 2017 showing Xofigo may have a much higher risk of serious side effects on bone marrow than thought!
A Single-center Retrospective Analysis of the Effect of Radium-223 (Xofigo) on Pancytopenia in Patients with Metastatic
Castration
-resistant Prostate Cancer. https://www.ncbi.nlm.nih.gov/pubmed/32140364 Another study, from Dec 2017: "The analysis of these parameters suggests that, in patients with a
A Single-center Retrospective Analysis of the Effect of Radium-223 (Xofigo) on Pancytopenia in Patients with Metastatic
Castration
-resistant Prostate Cancer. https://www.ncbi.nlm.nih.gov/pubmed/32140364 Another study, from Dec 2017: "The analysis of these parameters suggests that, in patients with a
JLS1
in
Advanced Prostate Cancer
4 years ago
MONOTHERAPY FOR NEWLY DIAGNOSED PROSTATE CANCER
Castration
can be done physically, hormonally or chemically. "Why should that be," asked I. "Just because the PCa cells have mutated (again) doesn't mean they're not still Ca, still lose reproductive ability when radiated."
Castration
can be done physically, hormonally or chemically. "Why should that be," asked I. "Just because the PCa cells have mutated (again) doesn't mean they're not still Ca, still lose reproductive ability when radiated."
RICH22
in
Advanced Prostate Cancer
4 years ago
"Oligomatastic", "Remission", & "Cure"--The Power of Words.
He even spoke of (in a couple of years) possibly being able to stop Lupron (
castration
) if this treatment gets my PSA down to undetectable as he feels it has a chance of doing.
He even spoke of (in a couple of years) possibly being able to stop Lupron (
castration
) if this treatment gets my PSA down to undetectable as he feels it has a chance of doing.
greatjohn
in
Advanced Prostate Cancer
4 years ago
Lynparza (olaparib )approved for mCRPC
The FDA has approved olaparib (Lynparza) for the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic
castration
-resistant prostate cancer (mCRPC) who have progressed following prior treatment with enzalutamide
The FDA has approved olaparib (Lynparza) for the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic
castration
-resistant prostate cancer (mCRPC) who have progressed following prior treatment with enzalutamide
Darryl
Partner
in
Advanced Prostate Cancer
4 years ago
Just evaluated as castration resistant
My urologist indicates that it appears I am becoming
castration
resistant. Assuming I am
castration
resistant, what would be the next step in SOC. I have been on Lupron alone since 9/2016. Also, can anyone recommend a medical oncologist in SW Florida?
My urologist indicates that it appears I am becoming
castration
resistant. Assuming I am
castration
resistant, what would be the next step in SOC. I have been on Lupron alone since 9/2016. Also, can anyone recommend a medical oncologist in SW Florida?
33947
in
Advanced Prostate Cancer
5 years ago
Latest results from MDA immunotherapy. trial for mCRPC using ipilimumab. MedPageToday & Science Translational Medicine - April 2020
From the MedPageToday article:
[i]A small clinical study of checkpoint inhibitors for metastatic
castration
-resistant prostate cancer (mCRPC) identified favorable and unfavorable subgroups that might help inform use of the drugs in a disease that generally has proven unresponsive to immunotherapy
From the MedPageToday article:
[i]A small clinical study of checkpoint inhibitors for metastatic
castration
-resistant prostate cancer (mCRPC) identified favorable and unfavorable subgroups that might help inform use of the drugs in a disease that generally has proven unresponsive to immunotherapy
cujoe
in
Fight Prostate Cancer
4 years ago
Appointment with MO what to do after abiraterone ( other version of zytiga )
perhaps he's going to be
castration
resistant from being hormone sensitive...are there chances of psa may stop at some point?..
perhaps he's going to be
castration
resistant from being hormone sensitive...are there chances of psa may stop at some point?..
Nirman
in
Advanced Prostate Cancer
5 years ago
Erleada in the EU for metastatic prostate cancer
Erleada is already approved in the EU for the treatment of men with non-metastatic
castration
-resistant prostate cancer.
Erleada is already approved in the EU for the treatment of men with non-metastatic
castration
-resistant prostate cancer.
Darryl
Partner
in
Advanced Prostate Cancer
4 years ago
Enzalutamide-Resistant PCa & 5-LOX Inhibition.
PMID: 32313135 DOI: 10.1038/s41598-020-62845-8 Abstract Much of the morbidity and mortality due to prostate cancer happen because of
castration
-resistant prostate cancer (CRPC) which invariably develops after anti-androgenic therapy.
PMID: 32313135 DOI: 10.1038/s41598-020-62845-8 Abstract Much of the morbidity and mortality due to prostate cancer happen because of
castration
-resistant prostate cancer (CRPC) which invariably develops after anti-androgenic therapy.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
BRN4, BRN2, Enzaludimide, and Neuroendrocine Prostate Cancer
Still as high as 40 percent of patients develop
castration
-resistant prostate cancer within a few years.
Still as high as 40 percent of patients develop
castration
-resistant prostate cancer within a few years.
Goldenwheels
in
Advanced Prostate Cancer
5 years ago
Overall Survival in Men With Bone Metastases From Castration-Resistant Prostate Cancer Treated With Bone-Targeting Radioisotopes
Both α-emitting and β-emitting bone-targeted radioisotopes (RIs) have been developed to treat men with metastatic
castration
-resistant prostate cancer (CRPC).
Both α-emitting and β-emitting bone-targeted radioisotopes (RIs) have been developed to treat men with metastatic
castration
-resistant prostate cancer (CRPC).
Balsam01
in
Advanced Prostate Cancer
5 years ago
New here, looking for some advice!
However the combination of ADT (androgen deprivation treatment (chemical
castration
)) and / or reactions to the drug Eligard itself, really took its tole on my cognitive ability and executive functions. Not trying to write a novel here but want to include pertinent info / history.
However the combination of ADT (androgen deprivation treatment (chemical
castration
)) and / or reactions to the drug Eligard itself, really took its tole on my cognitive ability and executive functions. Not trying to write a novel here but want to include pertinent info / history.
Jimhoy
in
Anxiety and Depression Support
4 years ago
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