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Castration
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Nivolumab+docetaxel trial
Hello, After ADT +Zytiga treatment, my cancer became
castration
-resistant. My MO suggested me to participate in Nivolumab/placebo + docetaxel trial, Phase 3. I checked the results of Phase 2, and, honestly, I was not very impressed with results.
Hello, After ADT +Zytiga treatment, my cancer became
castration
-resistant. My MO suggested me to participate in Nivolumab/placebo + docetaxel trial, Phase 3. I checked the results of Phase 2, and, honestly, I was not very impressed with results.
Catfish21
in
Advanced Prostate Cancer
2 years ago
In rare flop, Merck calls it quits on Keytruda-Lynparza combo in prostate cancer
Case in point: Merck & Co. just found out that a pairing of Keytruda and Lynparza wasn’t any better than an anti-androgen therapy in patients with previously treated metastatic
castration
-resistant prostate cancer (mCRPC).
Case in point: Merck & Co. just found out that a pairing of Keytruda and Lynparza wasn’t any better than an anti-androgen therapy in patients with previously treated metastatic
castration
-resistant prostate cancer (mCRPC).
fmenninger
in
Advanced Prostate Cancer
2 years ago
Preventing Drug Resistance - Thinking Outside The Box - PRINT Phase 2 Study
It is titled "Apalutamide, Darolutamide and Enzalutamide for Nonmetastatic
Castration
-Resistant Prostate Cancer (nmCRPC): A Critical Review" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997634/ In section 2.7 titled "Not All That Glitters Is Gold" they state: "Despite the exciting results of the SPARTAN
It is titled "Apalutamide, Darolutamide and Enzalutamide for Nonmetastatic
Castration
-Resistant Prostate Cancer (nmCRPC): A Critical Review" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997634/ In section 2.7 titled "Not All That Glitters Is Gold" they state: "Despite the exciting results of the SPARTAN
jazj
in
Advanced Prostate Cancer
2 years ago
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Lu PSMA treatment updates
I was diagnosed a year ago with metastatic PCa, and my reaction to Degerelix and Lupron soon revealed that it was already
castration
resistant. I’ve been through most SOC treatments and started Lu-PSMA in November through the early access program. Here’s my experience so far.
I was diagnosed a year ago with metastatic PCa, and my reaction to Degerelix and Lupron soon revealed that it was already
castration
resistant. I’ve been through most SOC treatments and started Lu-PSMA in November through the early access program. Here’s my experience so far.
Javelin18
in
Advanced Prostate Cancer
3 years ago
CAR-T Cell Therapy Trials
Prostate Cancer (mCRPC) Status: Recruiting Study Results: No Results Available Conditions: Prostatic Neoplasms,
Castration
-Resistant|Neoplasms by Histologic Type|Neoplasms, Prostate|Prostate Cancer|Metastatic
Castration
-resistant Prostate Cancer|Neoplasms|Prostatic Neoplasms|Genital Neoplasms, Male|
Prostate Cancer (mCRPC) Status: Recruiting Study Results: No Results Available Conditions: Prostatic Neoplasms,
Castration
-Resistant|Neoplasms by Histologic Type|Neoplasms, Prostate|Prostate Cancer|Metastatic
Castration
-resistant Prostate Cancer|Neoplasms|Prostatic Neoplasms|Genital Neoplasms, Male|
Hidden
in
Advanced Prostate Cancer
3 years ago
Should Early Use of Chemotherapy Be Avoided in the Treatment of Metastatic Prostate Cancer?
Previously, docetaxel was the only drug with evidences showing improved overall survival (OS) in metastatic
castration
-resistant prostate cancer (CRPC).
Previously, docetaxel was the only drug with evidences showing improved overall survival (OS) in metastatic
castration
-resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Abiraterone-Related Hypokalemia
PMID: 35505742 PMCID: PMC9055788 DOI: 10.7759/cureus.23678 Abstract Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating
castration
-resistant prostate cancer (CRPC).
PMID: 35505742 PMCID: PMC9055788 DOI: 10.7759/cureus.23678 Abstract Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating
castration
-resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Niraparib in Patients With Metastatic Castration-Resistant Prostate Cancer and DNA Repair Gene Defects
BACKGROUND Metastatic
castration
-resistant prostate cancers are enriched for DNA repair gene defects (DRDs) that can be susceptible to synthetic lethality through inhibition of PARP proteins.
BACKGROUND Metastatic
castration
-resistant prostate cancers are enriched for DNA repair gene defects (DRDs) that can be susceptible to synthetic lethality through inhibition of PARP proteins.
Balsam01
in
Advanced Prostate Cancer
2 years ago
New Member from Seattle
However as soon as the Chemo was done PSA started to climb, first to 4.1 in Feb, then by May up to 22.7… This is when Dr Zhao suggested genetic testing… Which found the BRCA2 mutation… Which explained the rising PSA… I am now diagnosed as Metastatic
Castration
Resistant!!
However as soon as the Chemo was done PSA started to climb, first to 4.1 in Feb, then by May up to 22.7… This is when Dr Zhao suggested genetic testing… Which found the BRCA2 mutation… Which explained the rising PSA… I am now diagnosed as Metastatic
Castration
Resistant!!
subliminaldood
in
Advanced Prostate Cancer
3 years ago
Talabostat Plus Pembrolizumab shows promise for mCRPC with Adenocarcinoma
BXCL701: First-in-class oral activator of systemic innate immunity combined with pembrolizumab, in patients with metastatic
castration
-resistant prostate cancer (mCRPC) of adenocarcinoma phenotype — Phase 2a results. Presented at: ASCO-GU 2022; February 17-19, 2022; Abstract 125.
BXCL701: First-in-class oral activator of systemic innate immunity combined with pembrolizumab, in patients with metastatic
castration
-resistant prostate cancer (mCRPC) of adenocarcinoma phenotype — Phase 2a results. Presented at: ASCO-GU 2022; February 17-19, 2022; Abstract 125.
Graham49
in
Advanced Prostate Cancer
2 years ago
Overview of 177Lu PSMA trials
pii=S0923-7534%2821%2903389-5 , https://clinicaltrials.gov/ct2/show/NCT04720157 and the PSMAfore trial for metastatic,
castration
resistant patients who had Zytiga or Xtandi but no chemo yet. https://clinicaltrials.gov/ct2/show/NCT04689828 This image is from a recent article by Zhang et al. https://www.mdpi.com
pii=S0923-7534%2821%2903389-5 , https://clinicaltrials.gov/ct2/show/NCT04720157 and the PSMAfore trial for metastatic,
castration
resistant patients who had Zytiga or Xtandi but no chemo yet. https://clinicaltrials.gov/ct2/show/NCT04689828 This image is from a recent article by Zhang et al. https://www.mdpi.com
GP24
in
Advanced Prostate Cancer
3 years ago
Digging into STAMPEDE data fir SBRT
It seems reasonable to me that patients with higher metastatic burden would be more likely to have
castration
resistant disease, since they would have had the disease, and been under ADT treatment, for a longer time.
It seems reasonable to me that patients with higher metastatic burden would be more likely to have
castration
resistant disease, since they would have had the disease, and been under ADT treatment, for a longer time.
Javelin18
in
Advanced Prostate Cancer
3 years ago
Questions for 2nd Meeting with MO tomorrow about reaction to 2 months on Orgovyx and Zytiga
Just read all replies to question about ADT and
castration
resistance . Feeling a bit overwhelmed . Started 2 months ago with a Firmagon shot then added Zytiga and switched to Orgovyx pills instead of Firmagon injection . I start 26 sessions of radiation on 1/6.
Just read all replies to question about ADT and
castration
resistance . Feeling a bit overwhelmed . Started 2 months ago with a Firmagon shot then added Zytiga and switched to Orgovyx pills instead of Firmagon injection . I start 26 sessions of radiation on 1/6.
PBnative
in
Advanced Prostate Cancer
3 years ago
Darolutamide & Simvastatin?
Statin derivatives as therapeutic agents for
castration
-resistant prostate cancer. Cancer Lett. 2016;383(1):94-105. Adashek JJ, Jain RK, Zhang J. Clinical development of PARP inhibitors in treating metastatic
castration
-resistant prostate.
Statin derivatives as therapeutic agents for
castration
-resistant prostate cancer. Cancer Lett. 2016;383(1):94-105. Adashek JJ, Jain RK, Zhang J. Clinical development of PARP inhibitors in treating metastatic
castration
-resistant prostate.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Assessment of Pain and HRQoL Scores With Olaparib Use in Patients With mCRPC
TAKE-HOME MESSAGE This open-label, randomised, phase III trial analyzed the effect of olaparib versus two control drugs on pain and health-related quality-of-life (HRQoL) measures in patients with metastatic
castration
-resistant prostate cancer (mCRPC) who had homologous recombination repair gene alterations
TAKE-HOME MESSAGE This open-label, randomised, phase III trial analyzed the effect of olaparib versus two control drugs on pain and health-related quality-of-life (HRQoL) measures in patients with metastatic
castration
-resistant prostate cancer (mCRPC) who had homologous recombination repair gene alterations
Balsam01
in
Advanced Prostate Cancer
2 years ago
Niraparib - GALAHAD trial
I had to smile at the opening sentence: "Metastatic
castration
-resistant prostate cancers are [i]enriched[/i] for DNA repair gene defects ..." Puts a positive spin on treatment-emergent adaptations responsible for CRPC.
I had to smile at the opening sentence: "Metastatic
castration
-resistant prostate cancers are [i]enriched[/i] for DNA repair gene defects ..." Puts a positive spin on treatment-emergent adaptations responsible for CRPC.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
VERU-111 (sabizabulin)
To be eligible, you have to have metastatic
castration
-resistant PCa and have failed at least one of: abiraterone,enzalutamide, darolutamide, or apalutamide. You may have had up to 2 cycles of chemo, but it had to be over a year ago.
To be eligible, you have to have metastatic
castration
-resistant PCa and have failed at least one of: abiraterone,enzalutamide, darolutamide, or apalutamide. You may have had up to 2 cycles of chemo, but it had to be over a year ago.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
My experience with Lu-177
This trial, still ongoing, is reserved for cancer resistant to
castration
never having received chemotherapy. In excellent physical condition with excellent blood patterns, I was scheduled to give me six LU-177 injections, one every six weeks.
This trial, still ongoing, is reserved for cancer resistant to
castration
never having received chemotherapy. In excellent physical condition with excellent blood patterns, I was scheduled to give me six LU-177 injections, one every six weeks.
Loujaro
in
Advanced Prostate Cancer
3 years ago
Rank Neutraceuticals / Off-Label Drugs By Most Likely Most Beneficial
So another question is do nutraceuticals that have a mild ADT-like effect essentially accelerate the cancer to become
castration
-resistant like ADT but just to a slower degree?
So another question is do nutraceuticals that have a mild ADT-like effect essentially accelerate the cancer to become
castration
-resistant like ADT but just to a slower degree?
jazj
in
Advanced Prostate Cancer
2 years ago
treatment post surgical castration
Chose surgical
castration
instead of Lupron. PSA went from 68 in July to 1.1 in Sept (10 days later), 0.6 in Oct. to 0.4 Nov. 2nd. Oncologist wants to start Nubega which is for non-metastatic
castration
-resistant pc, and has some pretty nasty side effects.
Chose surgical
castration
instead of Lupron. PSA went from 68 in July to 1.1 in Sept (10 days later), 0.6 in Oct. to 0.4 Nov. 2nd. Oncologist wants to start Nubega which is for non-metastatic
castration
-resistant pc, and has some pretty nasty side effects.
Pops78
in
Advanced Prostate Cancer
3 years ago
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