VERU-111 (sabizabulin)

[Tall_Allen]

I was just reading about the very positive findings for sabizabulin in treating Covid-19 and remembered that several members had been in early clinical trials for prostate cancer (under the name VERU-111).

fortune.com/2022/04/12/expe...

The reason it may work for prostate cancer is similar. In COVID-19, it prevents the virus from forming replicant virus copies. It is a "tubulin disrupter." Tubulin is the structure in all cells that allows the cell to hold its shape. When a cell replicates, it deconstructs the tubulin to allow the cell to form two cells (fission). Then each of the two cells reconstructs the tubulin, which allows the new cells to take shape and survive.

Taxanes (like docetaxel and cabazitaxel) stabilize the tubulin so the cancer cell cannot undergo fission into two cells. Cells that are trying to actively replicate die.

Sabizabulin disrupts the tubulin so that the cell cannot use it to form a stable cell. The hope is that it will be less toxic than taxane chemotherapy while being similarly effective.

In early trials, diarrhea was a common occurrence. The "enteric" cells of the intestines are actively growing, so it isn't surprising to see that side effect. But neutropenia and neuropathathy, which can be troubling side effects of taxane chemo, were not seen. They have adjusted the dose and give it with anti-diarrheal medication in new trials. So far, results have been good - certainly worth pursuing in Phase 3 trials.

aacrjournals.org/clincancer...

Phase 3 trials ("VERACITY") are recruiting throughout the US. To be eligible, you have to have metastatic castration-resistant PCa and have failed at least one of: abiraterone,enzalutamide, darolutamide, or apalutamide. You may have had up to 2 cycles of chemo, but it had to be over a year ago. Patients are randomized 2:1 to either get sabizabulin or one of the other advanced hormone therapies. Here are the details:

clinicaltrials.gov/ct2/show...

[HarGreg]

Thank you TA for being here for all of us!

[SPEEDYX]

Always on top of things...appreciate your dedication!

[j-o-h-n in reply to SPEEDYX]

So where's my praise?

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 04/15/2022 12:57 PM DST - Uncle Sam's original Birthday

[GeorgeGlass in reply to j-o-h-n]

Thanks John. You da man! 🍺

[j-o-h-n in reply to GeorgeGlass]

No No man you Da Man!!! 🥂

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 04/15/2022 1:15 PM DST - Uncle Sam's original Birthday

[SPEEDYX in reply to j-o-h-n]

To j-o-h-n who is always on top!!! And I appreciate his dedication for trying to make us laugh...one day he may succeed...that will be praise worthy for sure!!!!😍

[j-o-h-n in reply to SPEEDYX]

To sPEEDyx,

In boxing that's called an uppercut......(not expected).....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 04/15/2022 3:17 PM DST - Uncle Sam's original Birthday

[SPEEDYX in reply to j-o-h-n]

That was my best weapon!

[j-o-h-n in reply to SPEEDYX]

Yea but normally boxers use their hands not their knees....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 04/15/2022 3:45 PM DST - Uncle Sam's original Birthday

[SPEEDYX in reply to j-o-h-n]

No marquise of queens berry rules in brooklyn

[j-o-h-n in reply to SPEEDYX]

But since I live in Queens, the rules apply........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 04/15/2022 3:51 PM DST - Uncle Sam's original Birthday

[SPEEDYX in reply to j-o-h-n]

Your still better then ever!!!

[SPEEDYX in reply to j-o-h-n]

I can still sPeedyx fast!

[j-o-h-n in reply to SPEEDYX]

Yea but only lying down......

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 04/15/2022 3:46 PM DST - Uncle Sam's original Birthday

[SPEEDYX in reply to j-o-h-n]

This is true!

[Spyder54]

Sounds promising TA. Saved the post.

Best,

Mike

[cesces]

So very very very interesting.

[NickJoy]

Thank you TA. Do you think this would work on neuroendrochine cells ?

[Tall_Allen in reply to NickJoy]

Idk. But taxanes don’t work for NEPC.

[NickJoy in reply to Tall_Allen]

Ok thank you.

[Cateydid]

Thank you so much!! We see the on on the 27th, so I’ll review the study to develop thoughtful questions regarding my Joe’s next steps…

[j-o-h-n]

Thank you T_A

Good Luck, Good Health and Good Humo.

j-o-h-n Thursday 04/14/2022 7:33 PM EST

[shuckymesh62]

The new treatments are bittersweet for me, since my husband died 14 months ago. On the other hand, I feel this is awesome news.

[JamesHughs]

Thank you Tall Allen. Once again, I applaud you for your knowledge and caring. Thanks, Jim

[dorke]

Thank you TA.As always you bring up to date info.

Encouraging the amount of research been done on PC

[Tall_Allen in reply to dorke]

This is the tip of an iceberg of research. For every 10,000 compounds screened->250 (2.5%) are entered into a preclinical study -> just 5 (2% of those) are worth testing in clinical trials -> 1 gets FDA approval. That's why I never waste my and patient's time with the myriad of lab studies you can find posted on this site. Phase 3 trials are rare but worth our attention (and participation).

[Rocketman1960 in reply to Tall_Allen]

Running through the gates. Hoping for even more breakthroughs!

[Gabby643 in reply to Tall_Allen]

Thanks again T A!

[Cooolone]

Thank you for posting!

[dhccpa]

Very interesting indeed.

[twostrats]

Awesome to see a post like this from you

[anonymoose2]

Great information TA saved in favorites

Blessings 👍

[Shooter1]

This drug and trial looked good to me. It was especially good acct close in Spokane Washington. Only 2 1/2 hrs away. Sadly, to many cycles of chemo. My MO is looking at it for patients who are newer to their aPca trip.