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Castration
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Elevated PSA #’s from sex (after RT & ADT)
I’ve been on Active Surveillance since completing my ADT and RT both in 2017 &18 finally coming out of
castration
in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
I’ve been on Active Surveillance since completing my ADT and RT both in 2017 &18 finally coming out of
castration
in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
Jimhoy
in
Active Surveillance - Prostate Cancer
2 years ago
Genetics - Some answers but not all
ERG induces taxane resistance in
castration
-resistant prostate cancer. Nat. Commun. 2014;5:5548. doi: 10.1038/ncomms6548. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
ERG induces taxane resistance in
castration
-resistant prostate cancer. Nat. Commun. 2014;5:5548. doi: 10.1038/ncomms6548. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
spw1
in
Advanced Prostate Cancer
1 year ago
Xtandi (enzalutamide) alone is superior to ADT alone at preventing metastases in "high-risk" recurrent men
Also improved time to PSA progression/
castration
-resistance and time to chemo. No data yet on overall survival. Men achieving PSA≤ 0.2 ng/ml were given a vacation from therapy until PSA rose again. No QOL data yet.
Also improved time to PSA progression/
castration
-resistance and time to chemo. No data yet on overall survival. Men achieving PSA≤ 0.2 ng/ml were given a vacation from therapy until PSA rose again. No QOL data yet.
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
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It's the tumor stupid
The bureaucracy says those and other treatments that may be curative are reserved for patients for whom
castration
and radiation have failed. The bureacracy also wants us to wait for five year survival numbers.
The bureaucracy says those and other treatments that may be curative are reserved for patients for whom
castration
and radiation have failed. The bureacracy also wants us to wait for five year survival numbers.
traxcavator
in
Advanced Prostate Cancer
2 years ago
Statin Use Is Associated with Better Prognosis of Patients with Prostate Cancer after Definite Therapies:
Castration
therapy continues to be a "popular" PCa therapy. Early resistance continues to be common, even with add-on androgen-axis drugs. One form of resistance involves the generation of androgens from cholesterol - within the cancer cell. Statin use is insurance against that.
Castration
therapy continues to be a "popular" PCa therapy. Early resistance continues to be common, even with add-on androgen-axis drugs. One form of resistance involves the generation of androgens from cholesterol - within the cancer cell. Statin use is insurance against that.
pjoshea13
in
Fight Prostate Cancer
2 years ago
Cabergoline/ Dostinex/ Casodex - Prolactin suppression to remain Hormone sensitive
This leads to the development of “androgen-independent” malignancy; which is the status of advanced prostate cancer (
castration
resistant prostate cancer; CRPC). Androgen-independent advanced prostate cancer results in patient death generally in 2-5 years.
This leads to the development of “androgen-independent” malignancy; which is the status of advanced prostate cancer (
castration
resistant prostate cancer; CRPC). Androgen-independent advanced prostate cancer results in patient death generally in 2-5 years.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
PSA suppression
With Denmeade's BAT, testosterone levels are modulated - and there is no
castration
-only phase. In my original protocol, there was an abrupt shift from high-normal to castrate testosterone.
With Denmeade's BAT, testosterone levels are modulated - and there is no
castration
-only phase. In my original protocol, there was an abrupt shift from high-normal to castrate testosterone.
pca2004
in
Fight Prostate Cancer
8 months ago
How can I increase blood platelets?
This coincides with
castration
resistance setting in. Are there certain supplements that can raise the platelet count? What is the likely cause of the lower platelet count, which is normally about 130-140k for me. My recent tests have shown the count to be 100, 90, 86 and 110.
This coincides with
castration
resistance setting in. Are there certain supplements that can raise the platelet count? What is the likely cause of the lower platelet count, which is normally about 130-140k for me. My recent tests have shown the count to be 100, 90, 86 and 110.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Terbium-161 instead of Lutetium-177
VIOLET: A phase I/II trial evaluation of radioligand treatment in men with metastatic
castration
-resistant prostate cancer with [161Tb]Tb-PSMA-I&T. https://meetings.asco.org/abstracts-presentations/217246
VIOLET: A phase I/II trial evaluation of radioligand treatment in men with metastatic
castration
-resistant prostate cancer with [161Tb]Tb-PSMA-I&T. https://meetings.asco.org/abstracts-presentations/217246
TeleGuy
in
Advanced Prostate Cancer
2 years ago
Eliquis and Xtandi - Drug Interaction
Enzalutamide, a novel, oral androgen receptor antagonist used for the treatment of metastatic,
castration
-resistant prostate cancer, has been shown to improve overall and progression-free survival, prolong time to initiation of chemotherapy, reduce skeletal-related events, and carry a favorable adverse
Enzalutamide, a novel, oral androgen receptor antagonist used for the treatment of metastatic,
castration
-resistant prostate cancer, has been shown to improve overall and progression-free survival, prolong time to initiation of chemotherapy, reduce skeletal-related events, and carry a favorable adverse
Hawk56
in
Advanced Prostate Cancer
1 year ago
Actual duration of Lupron Depot 22.5 mg/12 weeks X 2.
Testoterone was below ''
Level'' from July 29th 2020 to March 10th 2021.
My PSA went from
[u]
0.18μg/L
[/u]
, July 29th 2020 down to 0.03μg/L on September 07 2022
Testoterone was below ''
Level'' from July 29th 2020 to March 10th 2021.
My PSA went from
[u]
0.18μg/L
[/u]
, July 29th 2020 down to 0.03μg/L on September 07 2022
doc1947g
in
Advanced Prostate Cancer
2 years ago
actual castration instead of ADT
I’m just throwing this out for discussion. I’m 62 in good over shape and recently started Lupron and Zytiga. I am told I will be on these or some form of ADT for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could
I’m just throwing this out for discussion. I’m 62 in good over shape and recently started Lupron and Zytiga. I am told I will be on these or some form of ADT for the rest of my life. Since the goal is to eliminate testosterone wouldn’t it make sense to remove the source of it? By doing so one could
OldGuysRule
in
Advanced Prostate Cancer
2 years ago
Мой опыт и мои мысли о прохождении радиолигандной терапии с использованием лиганда PSMA-617, содержащего изотопы 177Lu и 225Ac. Часть 2.
Also, I was advised to continue ADT in order to keep my Testosterone at
castration
values. Let me remind you that, by that time, I had not taken any antiandrogens. Dr.
Also, I was advised to continue ADT in order to keep my Testosterone at
castration
values. Let me remind you that, by that time, I had not taken any antiandrogens. Dr.
RusLand
in
Advanced Prostate Cancer
2 years ago
FYI: from the VA research information on Veterans
Drug could delay prostate cancer spread—In 2018, the Food and Drug Administration approved the use of apalutamide for
castration
-resistant prostate cancer that has not spread to other parts of the body.
Drug could delay prostate cancer spread—In 2018, the Food and Drug Administration approved the use of apalutamide for
castration
-resistant prostate cancer that has not spread to other parts of the body.
MouseAddams
in
Advanced Prostate Cancer
10 months ago
Advanced PC with a 90 years old
When he becomes
castration
resistant in the future, I'm afraid he won't have many options because of his age and health condition. With
castration
resistance, is ADT and another AR inhibitor or CYP17 inhibitor still a treatment option for him?
When he becomes
castration
resistant in the future, I'm afraid he won't have many options because of his age and health condition. With
castration
resistance, is ADT and another AR inhibitor or CYP17 inhibitor still a treatment option for him?
TN1932
in
Advanced Prostate Cancer
2 years ago
When is it time to discuss death with your oncologist?
He is the coordinating researcher of CAPRI (
CAstration
-resistant Prostate cancer RegIstry) https://youtu.be/wwvQXJo2aJE
He is the coordinating researcher of CAPRI (
CAstration
-resistant Prostate cancer RegIstry) https://youtu.be/wwvQXJo2aJE
Darryl
Partner
in
Advanced Prostate Cancer
2 years ago
Opinions on Lu-PSMA-617 Clinical Trial
Hello all, my father’s oncologist has suggested we start looking into clinical trials or chemotherapy now for his metastatic
castration
resistant prostate cancer (metastasized to the coccyx/pelvic bone in 2019). The trial the oncologist suggested is in the title.
Hello all, my father’s oncologist has suggested we start looking into clinical trials or chemotherapy now for his metastatic
castration
resistant prostate cancer (metastasized to the coccyx/pelvic bone in 2019). The trial the oncologist suggested is in the title.
PHnerd
in
Advanced Prostate Cancer
2 years ago
Long Term Zoloft/Sertraline, or other SSRI Treatment, might increase Coronary Artery Atherosclerosis and stroke risk
Nowadays, I fight mild depression (caused by cancer and
castration
meds) by exercising, listening to music I love, on good headphones, and drinking Jade Leaf Matcha green tea powder. I feel happiest after jogging with the headphone music playing.
Nowadays, I fight mild depression (caused by cancer and
castration
meds) by exercising, listening to music I love, on good headphones, and drinking Jade Leaf Matcha green tea powder. I feel happiest after jogging with the headphone music playing.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
New articles from the NIH
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
Magnus1964
in
Prostate Cancer Network
1 year ago
New NIH articles on prostate cancer
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with
castration
-resistant prostate cancer and skeletal metastases.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
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