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Carbidopa / Levodopa
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Has anyone tried Camicinal as a co-therapy with levodopa
A trial was run for the administration of Camicinal as an adjunct therapy with L-dopa and following was the outcome: In total 19 patients received the inactive placebo and 37 received 50mg of the study medicine GSK 962040, also called Camicinal. Those patients who took Camicinal showed an improvement
A trial was run for the administration of Camicinal as an adjunct therapy with L-dopa and following was the outcome: In total 19 patients received the inactive placebo and 37 received 50mg of the study medicine GSK 962040, also called Camicinal. Those patients who took Camicinal showed an improvement
Farooqji
in
Cure Parkinson's
3 months ago
Infusion therapy better than pills at reducing Parkinson’s symptoms
An international, multisite phase 3 trial published in the Lancet Neurology has found that continuous, 24-hour levodopa delivery through a subcutaneous infusion pump is safe and effective at reducing symptoms for longer periods of time. For the trial, 381 patients with Parkinson's disease in 16 countries
An international, multisite phase 3 trial published in the Lancet Neurology has found that continuous, 24-hour levodopa delivery through a subcutaneous infusion pump is safe and effective at reducing symptoms for longer periods of time. For the trial, 381 patients with Parkinson's disease in 16 countries
Farooqji
in
Cure Parkinson's
3 months ago
Levodopa only?
I was wondering if there are members of this forum who have been on large doses Levodopa - Madopar or Sinemet only - up to 1100 mg per 24h, for 5+ years.I would be grateful if you could comment on your present quality of life, and do you think that things could improve if other medications are added
I was wondering if there are members of this forum who have been on large doses Levodopa - Madopar or Sinemet only - up to 1100 mg per 24h, for 5+ years.I would be grateful if you could comment on your present quality of life, and do you think that things could improve if other medications are added
Daisies22
in
Cure Parkinson's
3 months ago
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Levodopa absorption
What makes absorption of the last (evening) Levodopa dose very poor regardless of the last meal taken before, or even on empty stomach?
What makes absorption of the last (evening) Levodopa dose very poor regardless of the last meal taken before, or even on empty stomach?
gesundheight
in
Cure Parkinson's
3 months ago
Request help
My RLS starts around 1 pm .and I take 1 50/200 Carbidopa which when busy helps . Later around 3 take 1 more . Still busy so ok . Then at 7pm when the body is resting " bam " the legs start . I then take 2 which sometime work but most of the time it takes 3-4 hours .. My concern is not the time as
My RLS starts around 1 pm .and I take 1 50/200 Carbidopa which when busy helps . Later around 3 take 1 more . Still busy so ok . Then at 7pm when the body is resting " bam " the legs start . I then take 2 which sometime work but most of the time it takes 3-4 hours .. My concern is not the time as
Dopa1
in
Restless Legs Syndrome
7 months ago
I don’t care which supplement is working.
I feel awesome; the combo could be placebo. Today I took: - 2 scoops of Inulin and a Probiotic first thing in the morning. My whole body felt tingly for 45 minutes. (Tingly may be the wrong word, it wasn’t unpleasant, more like a glow.) - Hour later: 1 Neurogan’s Urolithin A 700mg, 1 Fatty15, 1-1/
I feel awesome; the combo could be placebo. Today I took: - 2 scoops of Inulin and a Probiotic first thing in the morning. My whole body felt tingly for 45 minutes. (Tingly may be the wrong word, it wasn’t unpleasant, more like a glow.) - Hour later: 1 Neurogan’s Urolithin A 700mg, 1 Fatty15, 1-1/
Gcf51
in
Cure Parkinson's
3 months ago
Off Dyskinesia-anyone else have it? What's your fix?
Approximate 11 years into taking sinemet my pharmacy started only carrying generic versions. Which I'd when I started experiencing dyskinesia when the Carbidopa/levadopa started to wear off. And was told snd treated by a movement specialist that I was over medicated and attempted to reduce my dosage
Approximate 11 years into taking sinemet my pharmacy started only carrying generic versions. Which I'd when I started experiencing dyskinesia when the Carbidopa/levadopa started to wear off. And was told snd treated by a movement specialist that I was over medicated and attempted to reduce my dosage
YOParky
in
Cure Parkinson's
7 months ago
Awakenings...
Has anyone ever watched the movie
"Awakenings".
Really Awesome that people in a comatose state where awaken after 30 yr only to develop dyskinesia from high dose levodopa. I had tears in my eyes when they were awakened. The movie never mentioned that after
only one summer
that their dyskinesia
Has anyone ever watched the movie
"Awakenings".
Really Awesome that people in a comatose state where awaken after 30 yr only to develop dyskinesia from high dose levodopa. I had tears in my eyes when they were awakened. The movie never mentioned that after
only one summer
that their dyskinesia
Gcf51
in
Cure Parkinson's
4 months ago
Why Won't My Neurologist Listen (Explanation)
In a study of patients with early stage Parkinson’s disease, who were treated with
levodopa
/
carbidopa
or entacapone, in combination with
levodopa
/
carbidopa
for an average of about 3 years, prostate cancer was reported more frequently, in the group of patients that received entacapone.
In a study of patients with early stage Parkinson’s disease, who were treated with
levodopa
/
carbidopa
or entacapone, in combination with
levodopa
/
carbidopa
for an average of about 3 years, prostate cancer was reported more frequently, in the group of patients that received entacapone.
72andnotout
in
Cure Parkinson's
1 year ago
Arm swinging and levodopa
I was just wondering if anyone have their arm start to swing again after taking levodopa. My left arm does not swing freely when walking. Left leg also does not move well either.
I was just wondering if anyone have their arm start to swing again after taking levodopa. My left arm does not swing freely when walking. Left leg also does not move well either.
Glenfarclas
in
Cure Parkinson's
4 months ago
A good article on Levodopa (dosage, toxicity, precautions etc)
https://www.ncbi.nlm.nih.gov/books/NBK482140/#:~:text=Patients%20should%20take%20the%20oral,hours%20after%20meals%20containing%20protein.
https://www.ncbi.nlm.nih.gov/books/NBK482140/#:~:text=Patients%20should%20take%20the%20oral,hours%20after%20meals%20containing%20protein.
Farooqji
in
Cure Parkinson's
4 months ago
Supplement Cocktail is working (Massive B1 OD) or is it the Fatty15
5/8/24: I am one of two PwP (that I know of) that are taking Fatty15. They have never found their B1 sweet-spot. They are lowering their B1 dose in hopes of finding their sweet-spot. I started lowering my dose of B1 on day 15 of taking Fatty15.
There is a good possibility that Fatty15 is responsible
5/8/24: I am one of two PwP (that I know of) that are taking Fatty15. They have never found their B1 sweet-spot. They are lowering their B1 dose in hopes of finding their sweet-spot. I started lowering my dose of B1 on day 15 of taking Fatty15.
There is a good possibility that Fatty15 is responsible
Gcf51
in
Cure Parkinson's
4 months ago
Dyspnea when off
does anybody gets shortness of breath when levodopa is wearing off😳😳😳😥😥😥😥
does anybody gets shortness of breath when levodopa is wearing off😳😳😳😥😥😥😥
Rupa88
in
Cure Parkinson's
4 months ago
reasons for bad balance/dizzziness
I have identified 5 possible reasons for dizziness/lack of balance. 1. decreasing rasagiline too quickly 2. too much carbidopa 3. nOH (neurogenic orthostatic hypotension) Can be caused by rasagilene+rytary) 4. side effect of midodrine (increases when combined with rasagiline) 5. BPPV (a sort
I have identified 5 possible reasons for dizziness/lack of balance. 1. decreasing rasagiline too quickly 2. too much carbidopa 3. nOH (neurogenic orthostatic hypotension) Can be caused by rasagilene+rytary) 4. side effect of midodrine (increases when combined with rasagiline) 5. BPPV (a sort
pmmargo
in
Cure Parkinson's
7 months ago
Concentration of levodopa in plasma vs time curves for Madopar 100/25 IR, Madopar 100/25 CR, and Madopar 50/12.5 dispersible
Hello, I have been trying (unsuccessfully) to find the above graphs. In case someone has them, I would be really grateful if they could share the data. A link to a peer-reviewed paper would be best. Thank you in advance. D.
Hello, I have been trying (unsuccessfully) to find the above graphs. In case someone has them, I would be really grateful if they could share the data. A link to a peer-reviewed paper would be best. Thank you in advance. D.
Daisies22
in
Cure Parkinson's
4 months ago
IPX203 ;promising new PD drug?
I currently take rytary 4-5 times per day. My neuro thinks I may be a good candidate for this drug. In July 2023, thr drug manufacturer, Amneal,(if i understnd correctly) was working with FDA about safety of carbidopa in IPx203 https://parkinsonsnewstoday.com/ipx203-for-parkinsons-disease/ january
I currently take rytary 4-5 times per day. My neuro thinks I may be a good candidate for this drug. In July 2023, thr drug manufacturer, Amneal,(if i understnd correctly) was working with FDA about safety of carbidopa in IPx203 https://parkinsonsnewstoday.com/ipx203-for-parkinsons-disease/ january
Jmellano
in
Cure Parkinson's
7 months ago
Weakness in the legs
Dear all, My neurologist once said that Parkinson's disease is such that it requires 24-hour treatment. When it is ON, when it is OFF, etc. The weakness in my legs and the first step bother me the most. It helps me to make the first step longer, to encourage a proper gait. It helps me to step in place
Dear all, My neurologist once said that Parkinson's disease is such that it requires 24-hour treatment. When it is ON, when it is OFF, etc. The weakness in my legs and the first step bother me the most. It helps me to make the first step longer, to encourage a proper gait. It helps me to step in place
Margot59
in
Cure Parkinson's
4 months ago
Levodopa Phobia
An interesting tweet by Dr Okun, found worth sharing The term ‘Levodopa Phobia,' do you know where it came from? Should we be more careful about how we apply this term? Should we be careful of applying labels to people and scenarios? Should we be considering the perspective of the person with Parkinson's
An interesting tweet by Dr Okun, found worth sharing The term ‘Levodopa Phobia,' do you know where it came from? Should we be more careful about how we apply this term? Should we be careful of applying labels to people and scenarios? Should we be considering the perspective of the person with Parkinson's
Farooqji
in
Cure Parkinson's
4 months ago
Carpidopa RX
Do many people JUST take carbidopa with mucuna for better results? I want to ask my MDS for a RX, but I was quoted today that 30 would cost $248! Since it’s an old generic, I thought it would be dirt cheap! I’m wondering if it’s worth it to help Mucuna cross the BBB for better efficacy. I’m just dipping
Do many people JUST take carbidopa with mucuna for better results? I want to ask my MDS for a RX, but I was quoted today that 30 would cost $248! Since it’s an old generic, I thought it would be dirt cheap! I’m wondering if it’s worth it to help Mucuna cross the BBB for better efficacy. I’m just dipping
Ob6842
in
Cure Parkinson's
7 months ago
Co-Careledopa - what does science say - when to start taking
Hello, I was diagnosed Macrh '22. My doctor prescribed me 12.5mg / 50mg, two tablets to be taken three times per day. I feel fine just taking 1 tablet per day, two if I have a stressful day at work. Though I can imagine stepping up to two per day soon. I recently saw my Doctor. He recommended,
Hello, I was diagnosed Macrh '22. My doctor prescribed me 12.5mg / 50mg, two tablets to be taken three times per day. I feel fine just taking 1 tablet per day, two if I have a stressful day at work. Though I can imagine stepping up to two per day soon. I recently saw my Doctor. He recommended,
Nb11
in
Cure Parkinson's
11 months ago
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