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PSA to have stabilized after skyrocketing. What does this mean?
With PSA rising very rapidly four months ago after finishing Eclipse Trial, I had SBRT done immediately followed by Provenge. PSA on the day of SBRT was 2.0. It’s my understanding that Provenge will not affect PSA testing so it’s hard to determine progress. Obviously, there is still cancer still there
With PSA rising very rapidly four months ago after finishing Eclipse Trial, I had SBRT done immediately followed by Provenge. PSA on the day of SBRT was 2.0. It’s my understanding that Provenge will not affect PSA testing so it’s hard to determine progress. Obviously, there is still cancer still there
SViking
in
Advanced Prostate Cancer
5 months ago
mHSPCa with undetectable PSA - chemo-only?
Is chemo-only justified, without ADT/androgen receptor pathway inhibitors, in a case like mine with two new mets discovered and with PSA less than 0.1? I have had no SOC medication since 2.5 years, after SRBR to a single identified met. Gleason 9. This study points to ADT not being of benefit to low-PSA
Is chemo-only justified, without ADT/androgen receptor pathway inhibitors, in a case like mine with two new mets discovered and with PSA less than 0.1? I have had no SOC medication since 2.5 years, after SRBR to a single identified met. Gleason 9. This study points to ADT not being of benefit to low-PSA
Purple-Bike
in
Advanced Prostate Cancer
5 months ago
Platinum resistance
Hello, I'm stage 4 HGOC diagnosed Jan 2018. Had the usual surgery and chemo. Tried Parp Rubraca after recurrence and it didn't work reoccurred again last year, ended chemo of carboplatin and caelyx in October 2023. I've had CT scan and it's back again but as I'm now considered platinum resistant can
Hello, I'm stage 4 HGOC diagnosed Jan 2018. Had the usual surgery and chemo. Tried Parp Rubraca after recurrence and it didn't work reoccurred again last year, ended chemo of carboplatin and caelyx in October 2023. I've had CT scan and it's back again but as I'm now considered platinum resistant can
Fizzgirl
in
My Ovacome
5 months ago
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Update: NEPC Treatment
A few people messaged me regarding updates about my dad’s participation in Duke CHAMP trial for small cell/NEPC. He was admitted into trial Dec ‘23 and received 3 immunotherapy infusions until he had a very severe allergic reaction causing intense itching and grade 4 red rash all over his body. He admitted
A few people messaged me regarding updates about my dad’s participation in Duke CHAMP trial for small cell/NEPC. He was admitted into trial Dec ‘23 and received 3 immunotherapy infusions until he had a very severe allergic reaction causing intense itching and grade 4 red rash all over his body. He admitted
antisocialsocialwrkr
in
Advanced Prostate Cancer
3 months ago
Delay date for Lupron injection
I am due to get my third 6 monthly dose of Lupron injection in late May. I plan to travel during that time. Is there any harm if I should postpone the injection date by 2 or 3 weeks beyond the 6 months dateline?My PSA reading is currently below 0.1 ug/l. Secondly, I am contemplating going on ADT vacation
I am due to get my third 6 monthly dose of Lupron injection in late May. I plan to travel during that time. Is there any harm if I should postpone the injection date by 2 or 3 weeks beyond the 6 months dateline?My PSA reading is currently below 0.1 ug/l. Secondly, I am contemplating going on ADT vacation
John347
in
Advanced Prostate Cancer
5 months ago
Low PSA + high Gleason-FYI
I’ve just heard that this is a thing. Unfortunately it seems to affect my outcome. For instance, I had an initial PSA of 4.8 (4.6 after retesting), and I’m Gleason 9. Three of my doctors have mentioned it to me in passing (most recently today), which led me to Google it. https://www.ncbi.nlm.nih.gov
I’ve just heard that this is a thing. Unfortunately it seems to affect my outcome. For instance, I had an initial PSA of 4.8 (4.6 after retesting), and I’m Gleason 9. Three of my doctors have mentioned it to me in passing (most recently today), which led me to Google it. https://www.ncbi.nlm.nih.gov
Jpburns
in
Advanced Prostate Cancer
5 months ago
Malecare newsletter reports Finish study glucocorticoids (e.g. prednisone, prednisolone, dexamethasone) can lead to castrate resistance
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
“However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer. In prostate cancer, the glucocorticoid receptor can replace the activity of the androgen receptor, which is main oncogenic factor in this
Graham49
in
Advanced Prostate Cancer
3 months ago
OsteoDex: for mCRPC bone metastasis!
clinical trials are going well, and results are better than with zometa or Denosumab! https://mb.cision.com/Main/11652/3853506/2358495.pdf
clinical trials are going well, and results are better than with zometa or Denosumab! https://mb.cision.com/Main/11652/3853506/2358495.pdf
Maxone73
in
Advanced Prostate Cancer
5 months ago
Docetaxel results so far
People want to know if Docetaxel is worth doing due to the side effects. My husband just had a recent PSMA PET scan after 5 treatments and the result is compared with the same scan method done before treatment began: [i]Impression (Summary)[/i] [i]Mild improvement in subcarinal adenopathy, left lung
People want to know if Docetaxel is worth doing due to the side effects. My husband just had a recent PSMA PET scan after 5 treatments and the result is compared with the same scan method done before treatment began: [i]Impression (Summary)[/i] [i]Mild improvement in subcarinal adenopathy, left lung
Tinuriel
in
Advanced Prostate Cancer
5 months ago
It's Back!
This post should be good for newbies also. This should show you guys how long you can go!Anyways, 13 years ago I was diagnosed with PCA Gleason 7 PSA 44. With spread outside of prostate. Did 39 treatments off radiation and have been mostly on ADT for the duration except during COVID I took a break
This post should be good for newbies also. This should show you guys how long you can go!Anyways, 13 years ago I was diagnosed with PCA Gleason 7 PSA 44. With spread outside of prostate. Did 39 treatments off radiation and have been mostly on ADT for the duration except during COVID I took a break
Tjc1
in
Advanced Prostate Cancer
5 months ago
Looking for advice for my newly diagnosed dad
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Springsunshi
in
Advanced Prostate Cancer
3 months ago
Froedtert & the Medical College of Wisconsin Cancer Network created the Bone Metastasis Program
there will also be clinical trials focused on bone metastasis https://www.froedtert.com/stories/treating-cancer-spreads-bones
there will also be clinical trials focused on bone metastasis https://www.froedtert.com/stories/treating-cancer-spreads-bones
Maxone73
in
Advanced Prostate Cancer
5 months ago
Phase 2 trial recruiting: revert hormone resistance with apalutamide and ENV105
In phase 1 it worked with 44% of patients it seems, it's multisite, it could be worth trying for our warrior with mCRPC (metastatic castrate resistant prostate cancer) https://www.biospace.com/article/releases/kairos-pharma-doses-first-patient-in-phase-2-trial-of-lead-drug-candidate-env105-with-apalutamide-to-improve-therapy-sensitivity-for-castrate-resistant-prostate-cancer
In phase 1 it worked with 44% of patients it seems, it's multisite, it could be worth trying for our warrior with mCRPC (metastatic castrate resistant prostate cancer) https://www.biospace.com/article/releases/kairos-pharma-doses-first-patient-in-phase-2-trial-of-lead-drug-candidate-env105-with-apalutamide-to-improve-therapy-sensitivity-for-castrate-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
5 months ago
Ovarian cancer metastases to spine, hips and ribs
Hello ladies 🙂 My mother today was diagnosed with ovarian cancer that has metastases to her spine, hips and ribs. I read on the web that five-year survival rate [edited by moderator] sounds so little. I read some of your stories and I see that many of you have already live much longer. My mother soon
Hello ladies 🙂 My mother today was diagnosed with ovarian cancer that has metastases to her spine, hips and ribs. I read on the web that five-year survival rate [edited by moderator] sounds so little. I read some of your stories and I see that many of you have already live much longer. My mother soon
Tsioutsiou
in
My Ovacome
5 months ago
thy3f thyroid nodules on either side - doctors recommend total thyroidectomy
hi there I was recently diagnosed with 2 thy3f nodules on either side of my thyroid. Thy3f is an indeterminate result (25%malignancy 75% benign). I have no symptoms recently had a baby, breastfeeding, busy mom of 3 on no medication. Has anyone elected watch and wait tactic instead of thyroidectomy?
hi there I was recently diagnosed with 2 thy3f nodules on either side of my thyroid. Thy3f is an indeterminate result (25%malignancy 75% benign). I have no symptoms recently had a baby, breastfeeding, busy mom of 3 on no medication. Has anyone elected watch and wait tactic instead of thyroidectomy?
Indianyellow
in
Thyroid UK
5 months ago
Radiation?
just got my psa results after my first round of 4 months leuprolide and 3 months Zytiga and prednisone…..initially 18 now 0.04. Nurse told me that my MO would like to see me early to discuss more radiation( recent psma found areas of avidity only in prostate bed……initial tx was 48 grey imrt back in
just got my psa results after my first round of 4 months leuprolide and 3 months Zytiga and prednisone…..initially 18 now 0.04. Nurse told me that my MO would like to see me early to discuss more radiation( recent psma found areas of avidity only in prostate bed……initial tx was 48 grey imrt back in
Tommyj2
in
Advanced Prostate Cancer
5 months ago
Genitourinary Cancers Symposium Meeting Coverage, MedPage Today, January 2024
Latest 2024 PCa-related GuCS Meeting Coverage from MedPage Today: [i]
More Evidence That ARSIs for Prostate Cancer Differ in Cognitive Effects -More fatigue, depression, worse reaction time with enzalutamide as compared with abiraterone, January 29, 2024:
[/i] https://www.medpagetoday.com/meetingcoverage
Latest 2024 PCa-related GuCS Meeting Coverage from MedPage Today: [i]
More Evidence That ARSIs for Prostate Cancer Differ in Cognitive Effects -More fatigue, depression, worse reaction time with enzalutamide as compared with abiraterone, January 29, 2024:
[/i] https://www.medpagetoday.com/meetingcoverage
cujoe
in
Fight Prostate Cancer
5 months ago
Autovaccination seems a hot topic lately: Mt. Sinai autovaccination technique to turn cold prostate cancer hot (Phase 1)
ok, I am exposing myself to j-o-h-n in more than one way with that title... This is for regional leagues (locally advanced PCa), while we are the NFL of prostate cancer here, but the fact that a cold cancer was turned hot is very promising as it has always been the main limit of immuno therapies applied
ok, I am exposing myself to j-o-h-n in more than one way with that title... This is for regional leagues (locally advanced PCa), while we are the NFL of prostate cancer here, but the fact that a cold cancer was turned hot is very promising as it has always been the main limit of immuno therapies applied
Maxone73
in
Advanced Prostate Cancer
3 months ago
Barry
Hi, stage 4 prostate cancer 9 months in on anti testerone injections degatelix psa level has risen from 77 to 323, what are my chances?
Hi, stage 4 prostate cancer 9 months in on anti testerone injections degatelix psa level has risen from 77 to 323, what are my chances?
littlemount
in
Advanced Prostate Cancer
5 months ago
LATITUDE secondary analysis - Concurrent use of Abiraterone and NSAIDs - higher risk of Prostate Cancer Specific Mortality and inferior OS
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
Graham49
in
Advanced Prostate Cancer
5 months ago
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