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Benign prostatic hyperplasia
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Gleason 6, 1 Yr AS, now Gleason 3+4
Hi, I'm 65, fit, active. , 2 yrs ago noticed PSA doubled to 2.4, last yr 3.5 so had MRI and urine exosome test, "liquid biopsy". Range is 1-100, less than 15 and you are ok, o/w suggest a biopsy. Mine was 48. Oh, the 3 markers in this test are for more aggressive disease. BTW MRI only showed diffuse
Hi, I'm 65, fit, active. , 2 yrs ago noticed PSA doubled to 2.4, last yr 3.5 so had MRI and urine exosome test, "liquid biopsy". Range is 1-100, less than 15 and you are ok, o/w suggest a biopsy. Mine was 48. Oh, the 3 markers in this test are for more aggressive disease. BTW MRI only showed diffuse
Muggs1
in
Prostate Cancer Network
10 months ago
Oleic acid(OA), increases proliferation of highly malignant PC3 & DU145 PCa cells.Docetaxel cytotoxic action is significantly reduced by OA.
Of relevance, we found that FFA1/GPR40 is significantly overexpressed in tissue specimens of PCa, compared to
benign
prostatic
hyperplasia
tissues, at both mRNA and protein expression level, analyzed by Real Time RT-PCR and immunofluorescence experiments, respectively.
Of relevance, we found that FFA1/GPR40 is significantly overexpressed in tissue specimens of PCa, compared to
benign
prostatic
hyperplasia
tissues, at both mRNA and protein expression level, analyzed by Real Time RT-PCR and immunofluorescence experiments, respectively.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
clioquinol + zinc
PSA 44 started clioquinol +zinc Aug 11. Aug 30 PSA 48 with severe UTI. U of Maryland says Clio + zinc kills cancer cells. They give two cases of prostate cancer terminated. I'm trying it.
PSA 44 started clioquinol +zinc Aug 11. Aug 30 PSA 48 with severe UTI. U of Maryland says Clio + zinc kills cancer cells. They give two cases of prostate cancer terminated. I'm trying it.
agnut
in
Advanced Prostate Cancer
10 months ago
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PSA up to 150 on Olaprib, any insight on what’s next?
Hi all, my dads history is mostly in my profile but in short he started on Zytiga a year ago. Zytiga worked well but had major side effects and lead to a switch to Erleada. Erleada failed at the time shown in the picture with the orange circle and he switched to Olaprib by the time he got the PSA results
Hi all, my dads history is mostly in my profile but in short he started on Zytiga a year ago. Zytiga worked well but had major side effects and lead to a switch to Erleada. Erleada failed at the time shown in the picture with the orange circle and he switched to Olaprib by the time he got the PSA results
StayingSTRNG
in
Advanced Prostate Cancer
10 months ago
Olaparib? Chemo? or both ?
Hi All, Fathers latest PSA reading is 3.87 (up from 2.3 in 9/23) , he was switched from Enza to Abi last month but apparently it hasnt worked. He was also tested for germline mutations and found to be BRCA 2 +. His blood counts are relatively low with Hgb at 10.7 and RBC at 3.9 What are the options
Hi All, Fathers latest PSA reading is 3.87 (up from 2.3 in 9/23) , he was switched from Enza to Abi last month but apparently it hasnt worked. He was also tested for germline mutations and found to be BRCA 2 +. His blood counts are relatively low with Hgb at 10.7 and RBC at 3.9 What are the options
dudubaya
in
Advanced Prostate Cancer
8 months ago
Narirutin found in lemons, oranges, passion fruit, bergamot and grapefruit may be chemopreventive agent for hormone-resistant PC
Narirutin. A flavonoid found in citrus fruits modulates cell cycle phases and inhibits the proliferation of hormone-refractory prostate cancer cells by targeting hyaluronidase Author links open overlay panelShilpi Singh a b, Akhilesh Kumar Maurya c, Abha Meena a b, Nidhi Mishra c, Suaib Luqman a b
Narirutin. A flavonoid found in citrus fruits modulates cell cycle phases and inhibits the proliferation of hormone-refractory prostate cancer cells by targeting hyaluronidase Author links open overlay panelShilpi Singh a b, Akhilesh Kumar Maurya c, Abha Meena a b, Nidhi Mishra c, Suaib Luqman a b
Graham49
in
Advanced Prostate Cancer
1 year ago
CDK12 gene mutation
My husband continues to be hormone sensitive but Sept. 4, 2023 he developed intense and unrelenting pain in his right mandible. The oncologist and palliative care nurse prescribed morphine and dilaudid to help reduce the pain. These pain meds are helping although he can still feel pain and gets breakthrough
My husband continues to be hormone sensitive but Sept. 4, 2023 he developed intense and unrelenting pain in his right mandible. The oncologist and palliative care nurse prescribed morphine and dilaudid to help reduce the pain. These pain meds are helping although he can still feel pain and gets breakthrough
Decktime
in
Advanced Prostate Cancer
8 months ago
Just completed a whole gland TULSA procedure
This was salvage treatment after failure of SBRT by MRIdian in Mar 2020.PSA nadir after SBRT was 2.4 and it rose to 5.3 just 3 years later, when a PSMA scan showed 2 possible tumours within the gland. A subsequent biopsy confirmed local tumour recurrence with Gleason 4+4. Interventional radiotherapy
This was salvage treatment after failure of SBRT by MRIdian in Mar 2020.PSA nadir after SBRT was 2.4 and it rose to 5.3 just 3 years later, when a PSMA scan showed 2 possible tumours within the gland. A subsequent biopsy confirmed local tumour recurrence with Gleason 4+4. Interventional radiotherapy
Packidge
in
Advanced Prostate Cancer
8 months ago
Can I radiate a tumor mass abutting rectum wall & bladder wall on prostate bed?
RP w/ PLNR 03/2023 PSA RISING Nov 7, 2023 0.11ng/mL <=3.99 ng/mL Oct 10, 2023 0.09ng/mL <=3.99 ng/mL Sep 7, 2023 <0.06ng/mL <=3.99 ng/mL Aug 8, 2023 <0.06ng/mL <=3.99 ng/mL Jul 6, 2023 <0.06ng/mL <=3.99 ng/mL Isn’t it difficult to radiate a mass on prostate
RP w/ PLNR 03/2023 PSA RISING Nov 7, 2023 0.11ng/mL <=3.99 ng/mL Oct 10, 2023 0.09ng/mL <=3.99 ng/mL Sep 7, 2023 <0.06ng/mL <=3.99 ng/mL Aug 8, 2023 <0.06ng/mL <=3.99 ng/mL Jul 6, 2023 <0.06ng/mL <=3.99 ng/mL Isn’t it difficult to radiate a mass on prostate
Shorehousejam
in
Advanced Prostate Cancer
8 months ago
Questions about ADT drugs and insurance
Will Medicare cover Lupron injections under part B as it is not self administered (as opposed to pills)? If so how much will they cover (with a supplement plan). Regarding Orgovyx, since it is a pill and not an injection will it be covered under Medicare part D drug coverage? and if so do all of the
Will Medicare cover Lupron injections under part B as it is not self administered (as opposed to pills)? If so how much will they cover (with a supplement plan). Regarding Orgovyx, since it is a pill and not an injection will it be covered under Medicare part D drug coverage? and if so do all of the
SilverSeppi
in
Advanced Prostate Cancer
1 year ago
Decision Xtandi or radiation
Many posts proceed this one and I am now at a crossroad. Scans since 7/21 showed uptake in either/or illiac, acetabulum and the ischium. After 2/23 scan I had 35 gys radiation to acetabulum. PSA dropped then started rising, 9/23 scan showed SUV uptake 28.4 at ischium. PSA 4.2 Local radiologist is
Many posts proceed this one and I am now at a crossroad. Scans since 7/21 showed uptake in either/or illiac, acetabulum and the ischium. After 2/23 scan I had 35 gys radiation to acetabulum. PSA dropped then started rising, 9/23 scan showed SUV uptake 28.4 at ischium. PSA 4.2 Local radiologist is
alperk
in
Advanced Prostate Cancer
10 months ago
Lutetium 177 for "early" grade 4 pc or amino acid suppression ?
Dear All,It's a story of two brothers in the uk. Older brother was identified with 4+5 pc. His urologist recommended that any sibling be tested for pc. I did so and it was discovered that I had 3+4 pc. Older brother , via our national health care system, NHS, has systemic treatment ( chemo and hormone
Dear All,It's a story of two brothers in the uk. Older brother was identified with 4+5 pc. His urologist recommended that any sibling be tested for pc. I did so and it was discovered that I had 3+4 pc. Older brother , via our national health care system, NHS, has systemic treatment ( chemo and hormone
Wishyouwerehere
in
Prostate Cancer Network
8 months ago
Blood Test Results.
Some of you will remember it took me a month to get blood test results because in the first instance the Doc who arranged them wanted to give me the results. Made about 3 appointments which were cancelled because he changed his working days or whatever so eventually decided that just to get the results
Some of you will remember it took me a month to get blood test results because in the first instance the Doc who arranged them wanted to give me the results. Made about 3 appointments which were cancelled because he changed his working days or whatever so eventually decided that just to get the results
Desanthony
in
Atrial Fibrillation Support
8 months ago
SIB/Flame Protocol
The RO recommends Simultaneous Integrated Boost (SIB) as part of my treatment. PSA was 19.76 (4/2023), then 21.78 (5/2023 to confirm initial PSA). He is concerned that the PSA does not match the Gleason score (4+3, grade 3) as PSA has surpassed 20. Multiplanar MRI and PSMA PET indicated no metastasis
The RO recommends Simultaneous Integrated Boost (SIB) as part of my treatment. PSA was 19.76 (4/2023), then 21.78 (5/2023 to confirm initial PSA). He is concerned that the PSA does not match the Gleason score (4+3, grade 3) as PSA has surpassed 20. Multiplanar MRI and PSMA PET indicated no metastasis
805guy
in
Prostate Cancer Network
10 months ago
Your thoughts on next course of action
First, I'd like to thank the many good folks that contribute this forum. Your inputs have been a life send to me over the past several years, especially Tall Allen who recommended UW Medicine where my MO and RO are located. They have been fantastic to work with. The short story - Diagnosed in 2018.
First, I'd like to thank the many good folks that contribute this forum. Your inputs have been a life send to me over the past several years, especially Tall Allen who recommended UW Medicine where my MO and RO are located. They have been fantastic to work with. The short story - Diagnosed in 2018.
GBMV
in
Advanced Prostate Cancer
10 months ago
PLUVICTO
I finished 6 treatments of Pluvicto in May 2023 with negligible PSA readings. In August of 23 my PSA jumped to 2.3, my September 14 PSA is 16.8. It seems like Pluvicto is losing it's grip. I have an appointment with my oncologist on September 25. I am sure he will order a PSMA scan. I am curious as to
I finished 6 treatments of Pluvicto in May 2023 with negligible PSA readings. In August of 23 my PSA jumped to 2.3, my September 14 PSA is 16.8. It seems like Pluvicto is losing it's grip. I have an appointment with my oncologist on September 25. I am sure he will order a PSMA scan. I am curious as to
Jrb12
in
Advanced Prostate Cancer
10 months ago
PSA 6.9 six years after prostatectomy but PET/CT negative?
Weird situation here. Had a prostatectomy at Hopkins in early 2018. Organ-confined but Gleason on pathology was 4+5. For a little over two years PSA remained undetectable...and then, well, I kind of slacked off the test. Stupid and reckless on my part. After a roughly 3-year interval I recently
Weird situation here. Had a prostatectomy at Hopkins in early 2018. Organ-confined but Gleason on pathology was 4+5. For a little over two years PSA remained undetectable...and then, well, I kind of slacked off the test. Stupid and reckless on my part. After a roughly 3-year interval I recently
Nittany
in
Advanced Prostate Cancer
11 months ago
caught prostate cancer?
I have heard Dr. Schloz of you tube fame and one of our colleagues refer to PCA as “being caught”? Did we catch prostate cancer from a virus? I have a family history my father, his brother, my grandfather. But by far mine is the most aggressive? On my mothers side brca is present but she has had
I have heard Dr. Schloz of you tube fame and one of our colleagues refer to PCA as “being caught”? Did we catch prostate cancer from a virus? I have a family history my father, his brother, my grandfather. But by far mine is the most aggressive? On my mothers side brca is present but she has had
Nowhereman9
in
Advanced Prostate Cancer
1 year ago
Rising PSA last Lutetium 177 December 2022
My husband finished his 6th treatment of Lutetium 177, December 2022 PSA 1, PSA starting to rise May 4.6 September 8.4, the Oncologist can only offer Chemo, can refer him for R223 to another hospital, what are his choices now, chemo nearly killed him in 2010 Got COVID at Easter had 7 vaccinations,
My husband finished his 6th treatment of Lutetium 177, December 2022 PSA 1, PSA starting to rise May 4.6 September 8.4, the Oncologist can only offer Chemo, can refer him for R223 to another hospital, what are his choices now, chemo nearly killed him in 2010 Got COVID at Easter had 7 vaccinations,
Janhpr
in
Advanced Prostate Cancer
8 months ago
sarms
I have been thinking about trying ostarine for my locally advanced prostate cancer, osteoporosis and sarcopenia but I have been reading that sarms do not suppress p/c growth.
I have been thinking about trying ostarine for my locally advanced prostate cancer, osteoporosis and sarcopenia but I have been reading that sarms do not suppress p/c growth.
Radars
in
Advanced Prostate Cancer
1 year ago
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