sarms

[Radars]

I have been thinking about trying ostarine for my locally advanced prostate cancer, osteoporosis and sarcopenia but I have been reading that sarms do not suppress p/c growth.

[KocoPr]

Thats correct but ADT does. If you take Osterine you still need to be on ADT. I have taken it for a year now along with cardarine 10mg each daily while on SOC protocol of Orgovyx and darolutamide. Presently doing non SOC pBAT two wks on high T then two weeks if ADT and during ADT phase i go back on both Osterine and Cardarine. Search my posts on all my numbers after 1 year on it.

[Radars in reply to KocoPr]

thanks so sarms will be no good for me ,my testosterone is below the reference limit =none that is why I have now got severe osteoporosis with sarcopenia .

[KocoPr in reply to Radars]

SARMs helped me with muscle pain and strength thus building muscle puts strain on bone thus building bone density.

but to address bone loss you should have your E2 measured as it is probably undetectable which IMO is unacceptable.

Research low dose E2 add back for ADT treatments.

[Radars in reply to KocoPr]

what you mean add back for adt treatments, since finishing treatment in 2016 ,I have 6monthly psa checks which are undetectable at the moment, there is nothing for sarcopenia at the present.

[KocoPr in reply to Radars]

No no, add back estrogen E2

[Radars in reply to KocoPr]

my estrogen levels are ok been looking up symptoms

[KocoPr]

what is your estrogen level?

[Radars in reply to KocoPr]

don't know, but I have read all the symptoms people have got regarding estrogen problems, I think I will asked to be referred to a oncologist instead of urologist who said no to trt.

[KocoPr in reply to Radars]

If you have no testosterone you have no estrogen. It took 9 months of no T to lower my E2 to <10, then i started seeing symptoms of low E2 and it was ,,,well manopause. Bitchy, skin malodies and the biggest one you definitely have the symptoms of . Bone density.

Why are you reluctant to TELL your urologist or your PC to do a complete male hormone panel which should include all your estrogens. Make sure you ask for estrogen panel.

[Radars in reply to KocoPr]

thanks, I am back under the care of gp ,I have to ask him to refer me to whoever to check my estrogen level.

[PCaWarrior]

SARMs are not usually therapeutic. What they can do is reduce fat gain, bone loss, and muscle loss during ADT. A small dose is best. Approx 3 mg Rad-140 - some guys prefer ostarine but ostarine is a little more androgenic (therefore more caution needs to be exercised).

[maley2711 in reply to PCaWarrior]

Are these "sarms" SOC for the suggested uses...or still at trial stage?

[PCaWarrior in reply to maley2711]

I do not know. One was in a fast tracked trial for BCa. I don't know the status.

I doubt that you will find a doctor that will prescribe them for PCa SOC use. They are slightly androgenic (10:1 to 90:1 anabolic/androgenic ratio).

According to cancer.gov “Upon oral administration, SARM RAD140 acts as an agonist in select tissues, such as skeletal muscle and bone, where it binds to and activates androgen receptors (ARs). In the prostate and breasts, RAD140 acts as an antagonist and blocks AR activation and AR-mediated cellular proliferation. Therefore, this agent may improve bone formation and muscle mass and strength and may inhibit both the growth of the prostate in males and AR-dependent breast cancer cell proliferation.”.

I do not have faith in the prostate AR antagonist properties. I tested them and while they might act differently in other men, they have weak androgenic properties in me.

And, as advertised and as reported by athletes and bodybuilders, they have distinct anabolic properties.

[London441]

How much do you exercise and what kind? Supplementation only works as hard as you do.

[Radars in reply to London441]

with severe osteoporosis it's hard

[London441 in reply to Radars]

Yes that’s true, but inactivity is far worse, and sarms is not the answer. There is much you can do safely.

[Radars in reply to London441]

Yeah, I go for a walk every morning for 30mns to 45mns,I won't take sarms until I have to go back on adt exercise without testosterone and with severe osteoporosis and with sarcopenia you can't make any gains.

[PCaWarrior in reply to Radars]

It's a give and take. I tend to ignore all or nothing advice. I do what I can but do not hesitate to balance my risks.

[London441]

I’m sorry you’re in this condition, but the opposite is true. The less muscle you have, the faster you can begin to improve with consistent effort.

Walking is great, but we need to lift. Get a trainer if you can afford one. Inspiring, transformative results are there to be had, but forget ‘gains’. That term is more applicable to the young. Actual strength gains are much smaller and hard won even in healthy older people. You just want to move forward instead of backward.

[garyjp9]

I think men who do not have osteoporosis need to be very careful about their lecturing men who do have osteoporosis to get off their asses. Do you think we like having to be super cautious about new spinal injuries? Have you ever had the pleasure of a recommended trainer prescribe a lifting exercise only to shrug their shoulders and disappear when you collapse a vertebrae and cannot bend over. No, I'm guessing you have no idea.

[Radars in reply to garyjp9]

yeah with severe osteoporosis you have to be careful some people saying that you must keep increasing the weight as you go along, I am lifting light weights but it's dangerous to lifting more heavier weights, why do some people keep saying you must keep weight training with severe osteoporosis.

[garyjp9]

Because while they are well meaning, they do not understand our situation and have never experienced a sudden and life-altering vertebrae collapse while under the close supervision of a "highly qualified" trainer. When you are in our situation, you come to realize that no one will look out for you but you, or another brother in your same situation.

[Radars in reply to garyjp9]

dead right, they just move on to the next person, when I asked the royal osteoporosis society regarding weight training they said be careful if you use weights only light not heavy, they said and just use your own body weight I am ok to do pressups so that's not bad,

[garyjp9 in reply to Radars]

If they have sent you any tips for things to do or not do in terms of exercise, I'd be interested in reading them. In that case, you could DM me, if it's not too much trouble.

[Radars in reply to garyjp9]

what's dm mean ,easy exercises don't do situps don't bend forward to touch your toes, go on Google and search exercises for severe osteoporosis, they are easy..

[garyjp9]

Thanks. I used DM for direct message. I just sent you one to connect us.