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Benign prostatic hyperplasia
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PSA levels will increase over time, depending on the level of testosterone - Part I
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
janebob99
in
Prostate Cancer Network
5 months ago
Baseline PSMA-Pet scan?
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
duxlubber
in
Advanced Prostate Cancer
5 months ago
Failing ADT
Hi- I thought I would seek some advice before I meet with my MO tomorrow morning. I have responded well to treatment of metPC since my dx 11+ years ago. About 2+ years ago my PSA became measurable and was rising. After about a year or so I think it reached .37. Following a PSMA scan, my MO saw only
Hi- I thought I would seek some advice before I meet with my MO tomorrow morning. I have responded well to treatment of metPC since my dx 11+ years ago. About 2+ years ago my PSA became measurable and was rising. After about a year or so I think it reached .37. Following a PSMA scan, my MO saw only
jfoesq
in
Advanced Prostate Cancer
6 months ago
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Interesting study on combination of statins and metformin in high-risk patient outcomes
https://www.academia.edu/99363002/Individual_and_joint_effects_of_metformin_and_statins_on_mortality_among_patients_with_high_risk_prostate_cancer?email_work_card=view-paper Interesting paper - basically showing that statins reduce PCa mortality among high-risk PCa patients, metformin doesn't appear
https://www.academia.edu/99363002/Individual_and_joint_effects_of_metformin_and_statins_on_mortality_among_patients_with_high_risk_prostate_cancer?email_work_card=view-paper Interesting paper - basically showing that statins reduce PCa mortality among high-risk PCa patients, metformin doesn't appear
Don_1213
in
Advanced Prostate Cancer
5 months ago
PSA to have stabilized after skyrocketing. What does this mean?
With PSA rising very rapidly four months ago after finishing Eclipse Trial, I had SBRT done immediately followed by Provenge. PSA on the day of SBRT was 2.0. It’s my understanding that Provenge will not affect PSA testing so it’s hard to determine progress. Obviously, there is still cancer still there
With PSA rising very rapidly four months ago after finishing Eclipse Trial, I had SBRT done immediately followed by Provenge. PSA on the day of SBRT was 2.0. It’s my understanding that Provenge will not affect PSA testing so it’s hard to determine progress. Obviously, there is still cancer still there
SViking
in
Advanced Prostate Cancer
6 months ago
mHSPCa with undetectable PSA - chemo-only?
Is chemo-only justified, without ADT/androgen receptor pathway inhibitors, in a case like mine with two new mets discovered and with PSA less than 0.1? I have had no SOC medication since 2.5 years, after SRBR to a single identified met. Gleason 9. This study points to ADT not being of benefit to low-PSA
Is chemo-only justified, without ADT/androgen receptor pathway inhibitors, in a case like mine with two new mets discovered and with PSA less than 0.1? I have had no SOC medication since 2.5 years, after SRBR to a single identified met. Gleason 9. This study points to ADT not being of benefit to low-PSA
Purple-Bike
in
Advanced Prostate Cancer
6 months ago
High risk vs. aggressive cancer
I understand the definition of high-risk prostate cancer (Gleason, PSA and/or spread), but that doesn't necessarily seem to be the same thing as aggressive cancer. How can aggressiveness be determined for high risk, localized cancer? Thanks for any insight and information.
I understand the definition of high-risk prostate cancer (Gleason, PSA and/or spread), but that doesn't necessarily seem to be the same thing as aggressive cancer. How can aggressiveness be determined for high risk, localized cancer? Thanks for any insight and information.
RugbyVLS
in
Advanced Prostate Cancer
5 months ago
MY pBAT Stats From June to March 8 months
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
KocoPr
in
Fight Prostate Cancer
5 months ago
Tell Google that "Prostate Cancer" means something
Please help Malecare's YouTube channel reach more men and family members. We need 100 new subscribers to hit 4,500 by the end of the year. That should be an easy reach. Getting to 5,000 subscribers tripwires YouTube and Googles algorithm to elevate "prostate cancer" as a search term, which helps all
Please help Malecare's YouTube channel reach more men and family members. We need 100 new subscribers to hit 4,500 by the end of the year. That should be an easy reach. Getting to 5,000 subscribers tripwires YouTube and Googles algorithm to elevate "prostate cancer" as a search term, which helps all
Darryl
Partner
in
Advanced Prostate Cancer
7 months ago
Clinical trial: keep an eye on this
First results should be available by the first months of 2024. Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive
First results should be available by the first months of 2024. Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive
Maxone73
in
Advanced Prostate Cancer
7 months ago
Low PSA + high Gleason-FYI
I’ve just heard that this is a thing. Unfortunately it seems to affect my outcome. For instance, I had an initial PSA of 4.8 (4.6 after retesting), and I’m Gleason 9. Three of my doctors have mentioned it to me in passing (most recently today), which led me to Google it. https://www.ncbi.nlm.nih.gov
I’ve just heard that this is a thing. Unfortunately it seems to affect my outcome. For instance, I had an initial PSA of 4.8 (4.6 after retesting), and I’m Gleason 9. Three of my doctors have mentioned it to me in passing (most recently today), which led me to Google it. https://www.ncbi.nlm.nih.gov
Jpburns
in
Advanced Prostate Cancer
6 months ago
It's Back!
This post should be good for newbies also. This should show you guys how long you can go!Anyways, 13 years ago I was diagnosed with PCA Gleason 7 PSA 44. With spread outside of prostate. Did 39 treatments off radiation and have been mostly on ADT for the duration except during COVID I took a break
This post should be good for newbies also. This should show you guys how long you can go!Anyways, 13 years ago I was diagnosed with PCA Gleason 7 PSA 44. With spread outside of prostate. Did 39 treatments off radiation and have been mostly on ADT for the duration except during COVID I took a break
Tjc1
in
Advanced Prostate Cancer
6 months ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
5 months ago
ADT response and questions for MO
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Lovecherries
in
Advanced Prostate Cancer
5 months ago
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
Exrunner
in
Advanced Prostate Cancer
5 months ago
Enzalutamide vs Lupron Survival
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
janebob99
in
Prostate Cancer Network
5 months ago
Barry
Hi, stage 4 prostate cancer 9 months in on anti testerone injections degatelix psa level has risen from 77 to 323, what are my chances?
Hi, stage 4 prostate cancer 9 months in on anti testerone injections degatelix psa level has risen from 77 to 323, what are my chances?
littlemount
in
Advanced Prostate Cancer
6 months ago
În panica again
Hello, everybody! Wishing you a happy and bright spring! I need you expertise and oppinions again. My father is taking Xtandy for over 1.2 years and lately psa started to grow, I attached his psa situation since january 2022. I read about Xtandy here all the time. It never worked so good for him, I
Hello, everybody! Wishing you a happy and bright spring! I need you expertise and oppinions again. My father is taking Xtandy for over 1.2 years and lately psa started to grow, I attached his psa situation since january 2022. I read about Xtandy here all the time. It never worked so good for him, I
tuta1960
in
Advanced Prostate Cancer
5 months ago
advice re 0.02 reading
Hi everyone my first ever psa age 53 no symptoms 3.1 jan 2022 mri pri 3 hard prostate Gleason 3+3 no other scans mri did not detect the size of tumour l was told to go on active surveillance My brain said no ,choice given to me was remove prostate or brachytherapy l had operation in May 2022 all good
Hi everyone my first ever psa age 53 no symptoms 3.1 jan 2022 mri pri 3 hard prostate Gleason 3+3 no other scans mri did not detect the size of tumour l was told to go on active surveillance My brain said no ,choice given to me was remove prostate or brachytherapy l had operation in May 2022 all good
Ffghytrrg
in
Advanced Prostate Cancer
6 months ago
Pluvicto Question
Just had third Pluvicto in fusion and Spect scan today and got results. Not sure what this means. If the findings are similar compared to the last scan why does this indicate"technically successful" therapy. Also PSA went down just slightly after infusion number two but went up a little from PSA after
Just had third Pluvicto in fusion and Spect scan today and got results. Not sure what this means. If the findings are similar compared to the last scan why does this indicate"technically successful" therapy. Also PSA went down just slightly after infusion number two but went up a little from PSA after
spencoid2
in
Advanced Prostate Cancer
5 months ago
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