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Embark Phase 3 clinical trial
Came across this today --- https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
Came across this today --- https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
chefjlu
in
Advanced Prostate Cancer
5 months ago
ONCT-534
Greetings, Recently I read that the FDA is now fast tracking this new drug— ONCT-534. Apparently it’s meant to follow-up on drugs such as Abiraterone and Xtandi once they have failed. I’m curious if anyone here is participating in the trial — phase1/2–and if anyone has any information outside of the
Greetings, Recently I read that the FDA is now fast tracking this new drug— ONCT-534. Apparently it’s meant to follow-up on drugs such as Abiraterone and Xtandi once they have failed. I’m curious if anyone here is participating in the trial — phase1/2–and if anyone has any information outside of the
Lavender22
in
Advanced Prostate Cancer
5 months ago
SMYD3 enzyme involved in metastases
From msn Fullscreen button SMYD3 loss impedes PCa progression.(A) Expression of SMYD3 mRNA from TCGA [GTEX normal (n = 105), TCGA tumor adjacent normal (n = 49), primary tumors (n = 495)], Gulzar et al. [normal (n = 35), primary tumor (n = 43)] (30), and Ross-Adams et al. [normal (n = 73), primary
From msn Fullscreen button SMYD3 loss impedes PCa progression.(A) Expression of SMYD3 mRNA from TCGA [GTEX normal (n = 105), TCGA tumor adjacent normal (n = 49), primary tumors (n = 495)], Gulzar et al. [normal (n = 35), primary tumor (n = 43)] (30), and Ross-Adams et al. [normal (n = 73), primary
Derf4223
in
Advanced Prostate Cancer
5 months ago
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Mr Basil Charles
I was diagnosed with mestatic prostate cancer, PSA 29.1Spread to lymph node & bones in rib and spine My treatment plan 4 Abiraterone tablets 250gm & 1 Prednisone daily With a hormonal injection and bone strengthening drip quarterly After 2 years PSA dropped to 0.06 now it's 10.2 Lutetium 177 was
I was diagnosed with mestatic prostate cancer, PSA 29.1Spread to lymph node & bones in rib and spine My treatment plan 4 Abiraterone tablets 250gm & 1 Prednisone daily With a hormonal injection and bone strengthening drip quarterly After 2 years PSA dropped to 0.06 now it's 10.2 Lutetium 177 was
154Eleventh
in
Advanced Prostate Cancer
3 months ago
Updating my husband's journey, hoping it helps others - any words of encouragement are welcome, but please only positive comments
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
SuppWife
in
Advanced Prostate Cancer
3 months ago
WORRIED ABOUT REOCCURRENCE???
Worried....
Stopped IMRT 1 year ago and stopped adt (4 mos) 9 months ago...
9/23/23 Blood Test PSA .1 --- PSA FREE undetectable and Testosterone was 98
3/4/24 Blood Test PSA .2 ----Psa Free Undetectable and Testosterone not in yet.
I am concerned about the increase
Worried....
Stopped IMRT 1 year ago and stopped adt (4 mos) 9 months ago...
9/23/23 Blood Test PSA .1 --- PSA FREE undetectable and Testosterone was 98
3/4/24 Blood Test PSA .2 ----Psa Free Undetectable and Testosterone not in yet.
I am concerned about the increase
JWS13
in
Advanced Prostate Cancer
3 months ago
Pet Scan = "disease not detected"
Ok folks, has anyone come across something like this?...early 2018, PSA in the 50's, biopsy came back negative, a few months later PSA in the 60's, again, another biopsy and a negative finding, 3rd time in the 80's with yet another negative biopsy, then nuclear imaging and bam...stage 4 metastatic, this
Ok folks, has anyone come across something like this?...early 2018, PSA in the 50's, biopsy came back negative, a few months later PSA in the 60's, again, another biopsy and a negative finding, 3rd time in the 80's with yet another negative biopsy, then nuclear imaging and bam...stage 4 metastatic, this
GreyDragon55
in
Advanced Prostate Cancer
3 months ago
ERLEADA brain dead
Hey guys, everyone has been truly helpful on this site I keep posting as I endure my 18-24 months of hormone therapy that I have remaining. The last leg based on the Stampede Trial. I started on Lupron and Zytiga after successful radiation to my lymph node. This was seven years after proton radiation
Hey guys, everyone has been truly helpful on this site I keep posting as I endure my 18-24 months of hormone therapy that I have remaining. The last leg based on the Stampede Trial. I started on Lupron and Zytiga after successful radiation to my lymph node. This was seven years after proton radiation
icanwintwice
in
Advanced Prostate Cancer
5 months ago
promising against soft tissue and bone metastasis: AMG 509
there might be hope!! https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147455-esmo-2023-steap1-x-cd3-xmab-2-1-immune-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer-mcrpc-interim-results-phase-1-amg-509-xaluritamig.html
there might be hope!! https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147455-esmo-2023-steap1-x-cd3-xmab-2-1-immune-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer-mcrpc-interim-results-phase-1-amg-509-xaluritamig.html
Maxone73
in
Advanced Prostate Cancer
5 months ago
nothing new under the EMBARK sun!
Just a new standard of care emerging https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
Just a new standard of care emerging https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
Maxone73
in
Advanced Prostate Cancer
5 months ago
177Lu-PNT2002 Significantly Improves rPFS Vs ARPI in Metastatic Castration-Resistant Prostate Cancer
https://www.onclive.com/view/177lu-pnt2002-significantly-improves-rpfs-vs-arpi-in-metastatic-castration-resistant-prostate-cancer Lutetium seems to be a radiological miracle! Or maybe is the pr2002
https://www.onclive.com/view/177lu-pnt2002-significantly-improves-rpfs-vs-arpi-in-metastatic-castration-resistant-prostate-cancer Lutetium seems to be a radiological miracle! Or maybe is the pr2002
Maxone73
in
Advanced Prostate Cancer
5 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
3 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
3 months ago
PSA vs Testosterone at high T levels - Linear Model
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
janebob99
in
Advanced Prostate Cancer
3 months ago
PSMA Scan to be scheduled - thank you Tall Allen
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
Geno2853
in
Advanced Prostate Cancer
3 months ago
Help to do BAT treatment for my dad. Located in Norway.
Hello everyone! Writing on behalf of my father who is 67 yo and has prostate cancer. We are based in Norway. Prostatectomy done in March -17. Treated with Bicalutamide and Zoladex injection until rise in PSA 18 months ago. Increasing PSA from 6-12 on chemotherapy through last summer. September he was
Hello everyone! Writing on behalf of my father who is 67 yo and has prostate cancer. We are based in Norway. Prostatectomy done in March -17. Treated with Bicalutamide and Zoladex injection until rise in PSA 18 months ago. Increasing PSA from 6-12 on chemotherapy through last summer. September he was
VonKantarellen
in
Advanced Prostate Cancer
3 months ago
PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
3 months ago
Clinical Trial PT 112 ?
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
Enilorac63
in
Advanced Prostate Cancer
3 months ago
Is it PSA recurrence or not...
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
traveller64
in
Advanced Prostate Cancer
3 months ago
Mortality Probability after first PSA rise vs non-castrate testosterone levels (low vs Normal)
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
janebob99
in
Advanced Prostate Cancer
3 months ago
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