I turned 87 just 3 days' ago. My QOL is still good: no pain, and a lot of physical activity. Fatigue is mostly annoying, but I generally can work through it. The issue is my concern with a slowly rising PSA. Today's blood test showed a PSA of 1.5.
How concerned should I be, and are there steps to take that would help? Poollover
It would help if there was more information in your bio.
Not sure what else you want to know.
All I know from your bio is that you "added Zytiga-1000mg about 3 weeks ago and it has brought my PSA down to .98 from 1.8 with only Orgovyx." And from your post, which says the PSA has risen to 1.5.
It would be helpful to know if you still have a prostate or not, what treatment you have had and when, and if you have metastasis.
Just going from that little information you gave, I see two points. First, your PSA seemed a little resistant to ADT. You don't say how long you were on Orgovyx, but it took my PSA down to 0.38 in 1 month. Adding Zytiga took the PSA down to 0.11 in another month, and after 6 months I am at 0.02.
Second, your PSA is now actually rising on Orgovyx and Zytiga. That could mean you are now castrate-resistant and need to move on to chemo and radioligand therapies.
At 87, chemo and radiation , in my opinion, would do more harm than good. Doing something is not always better than just living your life a doing nothing.
You may be right, particularly as ADT doesn't appear to be doing much for what they cost me, and I don't mean financial.
Quality of life is important. PC is an industry and they tend to over treat. Partly due to money but also out of fear of being sued if they tell you to leave it alone. It’s important to do your own research and make your own decisions. I would recommend reading Anthony Horans book Rise and Fall of the the great prostate scam. His credentials are impeccable and his book really opened my eyes. I wish you well my friend.
Rising slowly after what therapy or therapies?
After Orgovyx and Zytiga and I switched from Prednisone to Dexamethasone at your suggestion. When initially tested I was Gleason 9 with many bone Mets. That was about 11 months ago. Since the cancer has already left the barn, it doesn't make sense to remove said organ, but why not radiate it. However, I'm 87 yrs. old. Is that a factor? Though I suffer from fatigue I'm still living an active enjoyable life. Essentially, I know I can't be cured, but would like as many QOF days or years as possible. I'm still without pain, but I'm slowly getting weaker. How much of that is cancer or age related, or both? I have a strong background in science and have little interest in wishful thinking. What would you do?
There is no benefit to irradiating the prostate and no known benefit to changing treatment while your PSA is low and slow.
Thanks for your incite.
Being 87 years old........ ain't so bad.................................................. it's terrible.
(Happy Belated birthday wishes).
Good Luck, Good Health and Good Humor.
j-o-h-n
I know nothing about them, but perhaps research the use of estrogen patches for comfort?
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