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FDA approves a new IND application of 225Ac-J591 (Actinium)
The FDA has granted clearance to an investigational new drug (IND) application for 225Ac-J591 (CONV01-α), a prostate-specific membrane antigen-targeted monoclonal antibody under investigation for the treatment of patients with advanced prostate cancer, announced Convergent Therapeutics, the developer
The FDA has granted clearance to an investigational new drug (IND) application for 225Ac-J591 (CONV01-α), a prostate-specific membrane antigen-targeted monoclonal antibody under investigation for the treatment of patients with advanced prostate cancer, announced Convergent Therapeutics, the developer
Maxone73
in
Advanced Prostate Cancer
4 months ago
Addition of an ARSI to standard ADT significantly increases the risk of fractures and falls in men with prostate cancer
Jones C, Gray S, Brown M, et al. Risk of fractures and falls in men with advanced or metastatic prostate cancer receiving androgen deprivation therapy and treated with novel androgen receptor signalling inhibitors: a systematic review and meta-analysis of randomised controlled trials. Eur Urol Oncol.
Jones C, Gray S, Brown M, et al. Risk of fractures and falls in men with advanced or metastatic prostate cancer receiving androgen deprivation therapy and treated with novel androgen receptor signalling inhibitors: a systematic review and meta-analysis of randomised controlled trials. Eur Urol Oncol.
Graham49
in
Advanced Prostate Cancer
4 months ago
Cortisol test result
Hi, I have just had some blood test results come back today. Currently on 5.5mg, but have been taking 6mg (Sat 30th..Sun, Mon, Tues) as have had lots going on, bit stressful but good stress not bad! the 0.5mg did help. All results are ok including PV, ESR, CRP. Also had a basal cortisol test (partially
Hi, I have just had some blood test results come back today. Currently on 5.5mg, but have been taking 6mg (Sat 30th..Sun, Mon, Tues) as have had lots going on, bit stressful but good stress not bad! the 0.5mg did help. All results are ok including PV, ESR, CRP. Also had a basal cortisol test (partially
Saffron23
in
PMRGCAuk
4 months ago
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'Wednesday Word"
Since my question yesterday was concerning 'brain fog', I thought my word for today should be [u][i]
encephalopathy
[/i][/u] - here are specifics about the word This is a blanket term referring to any brain dysfunction. It can commonly be called 'brain fog'. However, [u][i]
encephalopathy
Since my question yesterday was concerning 'brain fog', I thought my word for today should be [u][i]
encephalopathy
[/i][/u] - here are specifics about the word This is a blanket term referring to any brain dysfunction. It can commonly be called 'brain fog'. However, [u][i]
encephalopathy
DonnaBoll
Administrator
in
PBC Foundation
4 months ago
PSA after chemo # 4
Hi My husbands last chemo was # 3 and PSA was 0.14, he just got the results from Chemo # 4 and it was at 0.12. This is the slowest decline if you look in the profile Iisted all his PSA results. Should we be worried that this last one barely moved ? Or is this slower decline good news? Thanks for any
Hi My husbands last chemo was # 3 and PSA was 0.14, he just got the results from Chemo # 4 and it was at 0.12. This is the slowest decline if you look in the profile Iisted all his PSA results. Should we be worried that this last one barely moved ? Or is this slower decline good news? Thanks for any
positive-thinking
in
Advanced Prostate Cancer
4 months ago
How Much Carbidopa Levodopa After 5-10 Years? Any other meds?
I am about to "celebrate" the six year anniversary of my Parkinson's disease diagnosis. I currently take five 25/100 Carbidopa Levodopa tablets per day, usually around 9:00 a.m., noon, 3:00 p.m., 6:00 p.m., and 9:00 p.m. although timing varies slightly from day to day. Lately, I have noticed that I
I am about to "celebrate" the six year anniversary of my Parkinson's disease diagnosis. I currently take five 25/100 Carbidopa Levodopa tablets per day, usually around 9:00 a.m., noon, 3:00 p.m., 6:00 p.m., and 9:00 p.m. although timing varies slightly from day to day. Lately, I have noticed that I
jimcaster
in
Cure Parkinson's
4 months ago
Crohns/IBD
I have undiagnosed Crohns/IBD and continuous flares. I had surgery in 2011 resection of 20cm colon. What treatments are effective?
I have undiagnosed Crohns/IBD and continuous flares. I had surgery in 2011 resection of 20cm colon. What treatments are effective?
Lalande
in
Thyroid UK
4 months ago
Rising PCA - on ADT Holiday
Diagnosed Stage 4 oligometastatic (low volume) PCA in 2021. Gleason 7, 4+3 . Completed RT and 18 months on ADT (Nubeqa) paused the ADT in September after PSA non detectable and a fresh set of scans showed no “evidence of disease”. Continued to do bloodwork quarterly and PSA remained at 0. Until
Diagnosed Stage 4 oligometastatic (low volume) PCA in 2021. Gleason 7, 4+3 . Completed RT and 18 months on ADT (Nubeqa) paused the ADT in September after PSA non detectable and a fresh set of scans showed no “evidence of disease”. Continued to do bloodwork quarterly and PSA remained at 0. Until
Kkash
in
Advanced Prostate Cancer
4 months ago
Confused
UPDATE: April 5, 2024 Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned
UPDATE: April 5, 2024 Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned
MsHope
in
Advanced Prostate Cancer
4 months ago
Psa level
Just came off degarlix as psa level was rising, now on xtadi apalutamide how long does it take for psa level to fall and by how much?
Just came off degarlix as psa level was rising, now on xtadi apalutamide how long does it take for psa level to fall and by how much?
littlemount
in
Advanced Prostate Cancer
4 months ago
fibroscan score 7.9 f1 finrosis
I don’t understand this report as 7.9 Kos should indicate f2 fibrosis not f1 also the did not give me a cap score Not overweight very fit active no alcohol or any kind of hepatitis not hereditary conditions either So quite confused
I don’t understand this report as 7.9 Kos should indicate f2 fibrosis not f1 also the did not give me a cap score Not overweight very fit active no alcohol or any kind of hepatitis not hereditary conditions either So quite confused
TacosPizzaIcecream
in
British Liver Trust
4 months ago
My gfr is om 15 % already but I dont want dialysis
Hi everyone happy Easter, hope everyone is well so I'm already at 15 % gfr and so worried I do want to get in dialysis I want to go straight to the transplants . I when to recently get blood work at my gyno and it should my gfr 15 % but I have a cold and was a bit dehydrated since I drank k 2 bottle
Hi everyone happy Easter, hope everyone is well so I'm already at 15 % gfr and so worried I do want to get in dialysis I want to go straight to the transplants . I when to recently get blood work at my gyno and it should my gfr 15 % but I have a cold and was a bit dehydrated since I drank k 2 bottle
jennifer24
in
Early CKD Support
4 months ago
NCT04662580 - All about ARX517 as Monotherapy
Hello, Tomorrow I am going to participate in ARX517 as Monotherapy. Here is the clinical trial: https://www.clinicaltrials.gov/study/NCT04662580. Share your questions / positive comments. I will update here Special request to
Tall_Allen
- Please tell : what should I ask ? [
Hello, Tomorrow I am going to participate in ARX517 as Monotherapy. Here is the clinical trial: https://www.clinicaltrials.gov/study/NCT04662580. Share your questions / positive comments. I will update here Special request to
Tall_Allen
- Please tell : what should I ask ? [
God_Loves_Me
in
Advanced Prostate Cancer
4 months ago
Prostrate Removed, PSA increasing
Hello to all, Is there anyone who had their prostrate removed but PSA is increasing? Oncologist wants to try a new hormonal drug. Radiation was administered after surgery. PSA is increasing. We appreciate your feedback. P.S. Edited profile: “Last CAT Scan was November 2023 - Showed no metastases
Hello to all, Is there anyone who had their prostrate removed but PSA is increasing? Oncologist wants to try a new hormonal drug. Radiation was administered after surgery. PSA is increasing. We appreciate your feedback. P.S. Edited profile: “Last CAT Scan was November 2023 - Showed no metastases
BlessedParchy
in
Advanced Prostate Cancer
4 months ago
Is Jevtana easier to tolerate than docetaxel?
I have noticed that some men on this site have had over 30 infusions of Jevtana. My husband has had completed 10 sessions of docetaxel. The last three were given with a second dose of Carboplatin. Jevtana is new to us. How is it tolerated? Why can it be given at such a high number of doses?
I have noticed that some men on this site have had over 30 infusions of Jevtana. My husband has had completed 10 sessions of docetaxel. The last three were given with a second dose of Carboplatin. Jevtana is new to us. How is it tolerated? Why can it be given at such a high number of doses?
roboocme
in
Advanced Prostate Cancer
4 months ago
IMRT WITHOUT THE JELL
I'm scheduled for IMRT Radistion without the jell. Doc says the jell may push cancer microscopic cells away from the prostate. He said the cancer is about to protrude through the capsule and microsopic cancer cells could be out of the capsule and did not want to take a chance of putting the jell in and
I'm scheduled for IMRT Radistion without the jell. Doc says the jell may push cancer microscopic cells away from the prostate. He said the cancer is about to protrude through the capsule and microsopic cancer cells could be out of the capsule and did not want to take a chance of putting the jell in and
woppaginny
in
Advanced Prostate Cancer
4 months ago
Husband with PSP
Hi there My husband was 80 last week also diagnosed with Psp after an initial diagnosis of Parkinson’s He is Madopar four times a day plus to Amantandine the medication has helped a lot with his tremor His mobility is very poor, he had another fall today. The lack of empathy is very common and
Hi there My husband was 80 last week also diagnosed with Psp after an initial diagnosis of Parkinson’s He is Madopar four times a day plus to Amantandine the medication has helped a lot with his tremor His mobility is very poor, he had another fall today. The lack of empathy is very common and
Poodlelady1
in
PSP Association
4 months ago
Cat's Claw
Anyone out there know of taking Cat's Claw tiincture for Parkinson's shake ( tremor)? Anyother benefit?
Anyone out there know of taking Cat's Claw tiincture for Parkinson's shake ( tremor)? Anyother benefit?
b-bobble
in
Cure Parkinson's
4 months ago
Kidney issues because of CLL
Hello all! Anyone had kidney issues related to CLL? I will do the treatment not because of my lab results but because CLL filled my kidneys with white cells and led my to nephrotic syndrome. My hematologist is confident that with the treatment they will start to work again because those with cells
Hello all! Anyone had kidney issues related to CLL? I will do the treatment not because of my lab results but because CLL filled my kidneys with white cells and led my to nephrotic syndrome. My hematologist is confident that with the treatment they will start to work again because those with cells
BMFCDRW
in
CLL Support
4 months ago
Liver tumor
Hi there, I have been diagnosed 2 years ago with a rear benign condition in my peritoneum. Because of this, I have MRIs and CT scans every 4-5 months. In January, my doctors found out a new lesion in my liver. I had a MRI if my liver in March. They come back to me and said that the lesion not changed
Hi there, I have been diagnosed 2 years ago with a rear benign condition in my peritoneum. Because of this, I have MRIs and CT scans every 4-5 months. In January, my doctors found out a new lesion in my liver. I had a MRI if my liver in March. They come back to me and said that the lesion not changed
dibk
in
British Liver Trust
4 months ago
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