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PSA now at 15 time to start a treatment but don’t know which drugs.
It is time to beat the beast once and for all. I had RP and EBRT 2015 now PSA is climbing pretty quickly. PSA Trend 05/17/2022: 15.2 04/14/2022:13.45 03/09/2022: 13.3 02/09/2022: 10.3 01/12/2022: 8.4 12/01/2021: 8.93 09/15/2021: 3.6 07/21/2021: 3.08 06/21/2021: 2.4 03/23/2021: 1.8 02/25/2021
It is time to beat the beast once and for all. I had RP and EBRT 2015 now PSA is climbing pretty quickly. PSA Trend 05/17/2022: 15.2 04/14/2022:13.45 03/09/2022: 13.3 02/09/2022: 10.3 01/12/2022: 8.4 12/01/2021: 8.93 09/15/2021: 3.6 07/21/2021: 3.08 06/21/2021: 2.4 03/23/2021: 1.8 02/25/2021
KocoPr
in
Prostate Cancer Network
2 years ago
High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice
A new Finnish-Swedish paper (with no mention of NATO) [1] Dr. Myers has said that the purpose of ADT is to deny PCa access to dihydrotestosterone [DHT]. A minority of men produce DHT via the alternative pathway that does not involve testosterone [T]. Myers was one of the few doctors who checked DHT
A new Finnish-Swedish paper (with no mention of NATO) [1] Dr. Myers has said that the purpose of ADT is to deny PCa access to dihydrotestosterone [DHT]. A minority of men produce DHT via the alternative pathway that does not involve testosterone [T]. Myers was one of the few doctors who checked DHT
pjoshea13
in
Advanced Prostate Cancer
2 years ago
ADT, HDR Brachy, EBRT, Zytiga
Looking for input from this great community. I’m a high risk PC 72 yo. I’ve been on ADT since April 1. Getting HDR BT this Tuesday from Dr. Wong at UCSF. Expect to start EBRT two weeks after. Told by Dr. Wong that Zytiga for two years is likely warranted. He will refer me to MO for that. I’d be very
Looking for input from this great community. I’m a high risk PC 72 yo. I’ve been on ADT since April 1. Getting HDR BT this Tuesday from Dr. Wong at UCSF. Expect to start EBRT two weeks after. Told by Dr. Wong that Zytiga for two years is likely warranted. He will refer me to MO for that. I’d be very
WaterRat14
in
Prostate Cancer Network
2 years ago
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Duration of ADT
Just for a quick re cap, diagnosed December 2020. RP January 2021 with Gleason 4+3, extra-prostatic extension, 1 node pos T3aN1. Started ADT and abiraterone then 4m later pelvic RT. PSA still undetectable and Testosterone <2. The original plan was for 2 years of ADT and AA. At ESMO 2021 Dr
Just for a quick re cap, diagnosed December 2020. RP January 2021 with Gleason 4+3, extra-prostatic extension, 1 node pos T3aN1. Started ADT and abiraterone then 4m later pelvic RT. PSA still undetectable and Testosterone <2. The original plan was for 2 years of ADT and AA. At ESMO 2021 Dr
hg115pb
in
Advanced Prostate Cancer
2 years ago
PSA jump after 2weeks post-RALP - does this indicate CRPC?
Hi all. This situation is a bit abnormal, but wanted to gather some thoughts. My father was DX'ed last September with Gleason 4+4, tertiary 5. He had his RALP + PLND 2 weeks ago. Pathology showed ECE+, PNI+, SVI+, LVI-, 2/16 small LN mets (unfortunately, poorer than what imaging showed), and close PSM
Hi all. This situation is a bit abnormal, but wanted to gather some thoughts. My father was DX'ed last September with Gleason 4+4, tertiary 5. He had his RALP + PLND 2 weeks ago. Pathology showed ECE+, PNI+, SVI+, LVI-, 2/16 small LN mets (unfortunately, poorer than what imaging showed), and close PSM
sixmongoos
in
Advanced Prostate Cancer
2 years ago
Start of 36 mo of ADT?
I started on 36 months of ADT in Feb 2020 (Neoadjuvant) followed by 44 sessions of IMRT from May 2020 to July 2020 with Continuous ADT from Feb to now. When does the 36 months start from? From the first injection in Feb or from the finish of IMRT in July. I’ve found conflicting answers on line.
I started on 36 months of ADT in Feb 2020 (Neoadjuvant) followed by 44 sessions of IMRT from May 2020 to July 2020 with Continuous ADT from Feb to now. When does the 36 months start from? From the first injection in Feb or from the finish of IMRT in July. I’ve found conflicting answers on line.
Dracus
in
Prostate Cancer Network
2 years ago
Resistance bands for weight bearing exercise
Anyone using resistance bands in lieu of weights for weight bearing exercise? If so which kind? Any links to YouTube for training programs to prevent ADT muscle waste would be helpful. Thanks
Anyone using resistance bands in lieu of weights for weight bearing exercise? If so which kind? Any links to YouTube for training programs to prevent ADT muscle waste would be helpful. Thanks
Calhoun113
in
Advanced Prostate Cancer
2 years ago
Metastasized prostate cancer found in my lymph system after 8 years. Sneaky crap is NOT going to win!
Finished 45 radiation treatments, followed by hormone therapy for stage 4 prostate cancer, ending in February 2012. Was diagnosed with metastasized stage 4 in my lymph glands on November 29, 2021. Refusing chemo. Accepting Hormone shots and holding off on Xtandi for now. (Net monthly cost is well over
Finished 45 radiation treatments, followed by hormone therapy for stage 4 prostate cancer, ending in February 2012. Was diagnosed with metastasized stage 4 in my lymph glands on November 29, 2021. Refusing chemo. Accepting Hormone shots and holding off on Xtandi for now. (Net monthly cost is well over
Old90
in
Advanced Prostate Cancer
2 years ago
ADT Vacation - Update 3
Well, I finally had my PSMA scan this week and met with my MO. The scan showed a small met on my pelvic bone very near to the met or a part of the met that was previously radiated but possibly outside the radiation field. Besides that I’m clear. Pending a consultation with my RO we are thinking/hoping
Well, I finally had my PSMA scan this week and met with my MO. The scan showed a small met on my pelvic bone very near to the met or a part of the met that was previously radiated but possibly outside the radiation field. Besides that I’m clear. Pending a consultation with my RO we are thinking/hoping
fireandice123
in
Advanced Prostate Cancer
2 years ago
Overview of ADT.
A nice overview from the government. For many of us not a lot new here but speaking for myself, I would have learned a lot very rapidly if I had read this 4 years ago (right after diagnosis). Hormone Therapy for Prostate Cancer Fact Sheet - NCI https://www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet
A nice overview from the government. For many of us not a lot new here but speaking for myself, I would have learned a lot very rapidly if I had read this 4 years ago (right after diagnosis). Hormone Therapy for Prostate Cancer Fact Sheet - NCI https://www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet
Hidden
in
Advanced Prostate Cancer
2 years ago
Why I Choose an Unproven Treatment
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
MateoBeach
in
Fight Prostate Cancer
2 years ago
Why I Choose an Unproven Treatment
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
MateoBeach
in
Advanced Prostate Cancer
2 years ago
We have reached castrate resistance...what to do next?
I have been following this forum for a couple of years now, and have learned so much from all of you. But this is my first time to post...I knew this time would eventually come, but somehow it still caught me off guard. Dad is now 75; he was diagnosed with stage IV metastatic prostate cancer December
I have been following this forum for a couple of years now, and have learned so much from all of you. But this is my first time to post...I knew this time would eventually come, but somehow it still caught me off guard. Dad is now 75; he was diagnosed with stage IV metastatic prostate cancer December
Bmvg02
in
Advanced Prostate Cancer
2 years ago
30 months with PCA - experiences with ADT, Docetaxel, Xtandi / Nubeqa, Provenge and experimental immunotherapy trial.
Hi, I posted for the first time on this forum after my father (59) was diagnosed with stage IV prostate cancer in November of 2019. I want to share our progress in this fight so far so that it can be added to the repository and used by others down the line to make informed decisions about treatment
Hi, I posted for the first time on this forum after my father (59) was diagnosed with stage IV prostate cancer in November of 2019. I want to share our progress in this fight so far so that it can be added to the repository and used by others down the line to make informed decisions about treatment
Namork
in
Advanced Prostate Cancer
2 years ago
Orgovyx and estradiol?
Howdy all, been following some discussions here about using estradiol patches with ADT and I was wondering if anyone is using estradiol with Orgovyx. I've been on Orgovyx for over 7 months now and my PSA has been undetectable so far and I feel I'm tolerating it well. See my profile for my full treatment
Howdy all, been following some discussions here about using estradiol patches with ADT and I was wondering if anyone is using estradiol with Orgovyx. I've been on Orgovyx for over 7 months now and my PSA has been undetectable so far and I feel I'm tolerating it well. See my profile for my full treatment
NewPotatoCaboose
in
Advanced Prostate Cancer
2 years ago
Rank Neutraceuticals / Off-Label Drugs By Most Likely Most Beneficial
I'm curious about the opinions of members here on how they would currently rank Neutraceutical and off-label use drugs in order of highest benefit potential (most confirming clinical trial evidence combined with actual therapeutic or synergistic therapeutic effect) in slowing/stopping PCa progression
I'm curious about the opinions of members here on how they would currently rank Neutraceutical and off-label use drugs in order of highest benefit potential (most confirming clinical trial evidence combined with actual therapeutic or synergistic therapeutic effect) in slowing/stopping PCa progression
jazj
in
Advanced Prostate Cancer
2 years ago
Time for action?
Hi It’s been 4 years since my last contact with this site (though I view it daily). Over that time my PSA has been slowly, but surely, edging up. My history in brief is dx Dec2013 with PSA 5.1 G9Tb3 PNI ECE. Had 78gy of radiation therapy early in 2014 and 3 years on Lupron (finished Feb/2017). No
Hi It’s been 4 years since my last contact with this site (though I view it daily). Over that time my PSA has been slowly, but surely, edging up. My history in brief is dx Dec2013 with PSA 5.1 G9Tb3 PNI ECE. Had 78gy of radiation therapy early in 2014 and 3 years on Lupron (finished Feb/2017). No
Birdwood
in
Advanced Prostate Cancer
2 years ago
Intermittent secondary ADT
I'm currently taking Xtandi while waiting to start a CAR-T trial. Due to the way scheduling is working out, I'm starting and stopping Xtandi three times. It occurs to me that this might have a benefit similar to Bipolar Androgen Therapy, where it might delay resistance to Xtandi and kill more of the
I'm currently taking Xtandi while waiting to start a CAR-T trial. Due to the way scheduling is working out, I'm starting and stopping Xtandi three times. It occurs to me that this might have a benefit similar to Bipolar Androgen Therapy, where it might delay resistance to Xtandi and kill more of the
Javelin18
in
Advanced Prostate Cancer
2 years ago
Continuing intermittent ADT? or more?
I appreciate having learned much following this site. 74 year old, very active, runner, hiker, retired ER RN, married, sexually active Brief long hx: Diagnosed 2001 PSA 3.2 (high velocity), RP Gleason 3+4, one nerve spared, negative margins and nodes. 2015 BCR, 2016 salvage radiation to bed for
I appreciate having learned much following this site. 74 year old, very active, runner, hiker, retired ER RN, married, sexually active Brief long hx: Diagnosed 2001 PSA 3.2 (high velocity), RP Gleason 3+4, one nerve spared, negative margins and nodes. 2015 BCR, 2016 salvage radiation to bed for
whitebird
in
Advanced Prostate Cancer
2 years ago
Does this sound like NePCA?
Last ct scan was 6 months ago it was clear but psa was on the rise. Over the next few months psa rose to 7.2 and then back to 6.6 6 weeks ago. My father recently had a pace maker fitted and chest X-ray revealed a couple of spots. Was sent for ct scan getting results this week. Hx diagnosed 2018 with
Last ct scan was 6 months ago it was clear but psa was on the rise. Over the next few months psa rose to 7.2 and then back to 6.6 6 weeks ago. My father recently had a pace maker fitted and chest X-ray revealed a couple of spots. Was sent for ct scan getting results this week. Hx diagnosed 2018 with
Poppi07
in
Advanced Prostate Cancer
2 years ago
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