Does this sound like NePCA?

[Poppi07]

Last ct scan was 6 months ago it was clear but psa was on the rise. Over the next few months psa rose to 7.2 and then back to 6.6 6 weeks ago. My father recently had a pace maker fitted and chest X-ray revealed a couple of spots. Was sent for ct scan getting results this week. Hx diagnosed 2018 with extensive Mets responded well to chemo, adt and then recently xtandi for 2 years. I’m scared these spots suggest neuroendocrine variant. Thoughts?

[Tall_Allen]

If it responded to chemo, ADT and Xtandi, it definitely is not neuroendocrine. There are many types of low PSA PCa that are not NEPC.

[Poppi07 in reply to Tall_Allen]

Thank you! So grateful we have ppl like you here with such a breadth of information. Cheers

[Poppi07]

Ok- thanks I’ll hold tight for today and see what these scans reveal. Much appreciated

[Hidden]

He responded to ADT and Xtandi. Not NEPC.

[dhccpa]

How involved is getting the Chromogranin A blood test?

[Hidden in reply to dhccpa]

Go online to ultalabtests.com and order one yourself unless you want to go through the doctor. $168. Just to clear out my FSA upon retirement I did that for fibrinogen, ldh, chromagranin-A, hepatic function panel, bone-specific ALP, sed rate, C-reactive protein, Thyroid panels, and of course, PSA ultra sensitive and testosterone free and total. Got out of all that for around $500. My Chromagranin-A was 360 ng/ml with normal at <311, but none of the others were out of kilter so i chalked that up to me being an inflammatory kind of guy. Plus this may have been Ultalab's version of the Chromagranin-A; there seems to be more than one test.

[dhccpa]

Thanks