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Androgen deprivation therapy (ADT)
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Intracrinology-Revisited and Prostate Cancer
Thus, adaptive responses in the canonical, alternative and backdoor pathways due to
ADT
would be effectively surmounted by inhibition of AKR1C3. The challenge is to develop AKR1C3 isoform selective inhibitors that do not inhibit the highly related AKR1C1 and AKR1C2 enzymes.
Thus, adaptive responses in the canonical, alternative and backdoor pathways due to
ADT
would be effectively surmounted by inhibition of AKR1C3. The challenge is to develop AKR1C3 isoform selective inhibitors that do not inhibit the highly related AKR1C1 and AKR1C2 enzymes.
KocoPr
in
Fight Prostate Cancer
2 years ago
Dubious ADT treatment
Overall I'm somewhat worried this whole ordeal with starting
ADT
so early and not even following it correctly did more harm than good. Is it an expected result after stopping this treatment?
Overall I'm somewhat worried this whole ordeal with starting
ADT
so early and not even following it correctly did more harm than good. Is it an expected result after stopping this treatment?
Mustbecursed
in
Advanced Prostate Cancer
2 years ago
Very slow start getting treatment and diagnosis
Hi everyone, My dad went to the doctor recently and discovered he has a psa of 255. His doctor ordered him a psma pet scan for a week later which was supposed to be today. He shows up and Kaiser cancelled the scan. They told me it happens a lot that radiology appointments need to be cancelled (? Not
Hi everyone, My dad went to the doctor recently and discovered he has a psa of 255. His doctor ordered him a psma pet scan for a week later which was supposed to be today. He shows up and Kaiser cancelled the scan. They told me it happens a lot that radiology appointments need to be cancelled (? Not
AppleTree43
in
Advanced Prostate Cancer
1 year ago
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T3 monotherapy people
Just a quick question for those on T3 only out of curiosity - what is your overall dose, your split dose (if any) and how long did it take you to get there? I know it’s different for everyone but would be interesting to see how others work their dosing ☺️ So far gradually up to 65mcg, definitely
Just a quick question for those on T3 only out of curiosity - what is your overall dose, your split dose (if any) and how long did it take you to get there? I know it’s different for everyone but would be interesting to see how others work their dosing ☺️ So far gradually up to 65mcg, definitely
Beau55
in
Thyroid UK
11 months ago
How content should I be with my current treatment 🤷
Sounds like a logic hole to me 🤔 And when I've brought up to my MO the idea of just
ADT
vacation (s) much less BAT, the conversation seems to dissipate. So I'm wavering.
Sounds like a logic hole to me 🤔 And when I've brought up to my MO the idea of just
ADT
vacation (s) much less BAT, the conversation seems to dissipate. So I'm wavering.
Lewellen
in
Advanced Prostate Cancer
2 years ago
What Now Pt 2
Is it time for a vacation from
ADT
, or time for a new Oncologist, or both?
Is it time for a vacation from
ADT
, or time for a new Oncologist, or both?
Hidden
in
Advanced Prostate Cancer
2 years ago
Is it the NDT (Thailand)
Have taken 2.5 grains NDT for many years. Recently started suffering from burning feet pads and tongue swelling late evening. Have noticed that the batch number for the NDT I currently take was hi-lighted for some reason on a facebook page but cannot find the page and reason why. The GP has referred
Have taken 2.5 grains NDT for many years. Recently started suffering from burning feet pads and tongue swelling late evening. Have noticed that the batch number for the NDT I currently take was hi-lighted for some reason on a facebook page but cannot find the page and reason why. The GP has referred
dyfrdwy
in
Thyroid UK
11 months ago
Let's Talk Kidney Issues
Could these kidney issues be related to PC treatment,
ADT
, low T, incontinence, radiation? Anyone else having Kidney issues since being diagnosed or treated for PC?
Could these kidney issues be related to PC treatment,
ADT
, low T, incontinence, radiation? Anyone else having Kidney issues since being diagnosed or treated for PC?
Moespy
in
Advanced Prostate Cancer
2 years ago
First PSMA pet scan
He’s been having regular pet scans , all good, no new Mets, thank God Since PSA doubling month over month, on
ADT
and Casodex, time for something else? PSA still low considering. .19. seeing MO after PSMA , advise/ thoughts, TIA
He’s been having regular pet scans , all good, no new Mets, thank God Since PSA doubling month over month, on
ADT
and Casodex, time for something else? PSA still low considering. .19. seeing MO after PSMA , advise/ thoughts, TIA
Keeper70
in
Advanced Prostate Cancer
2 years ago
iron test results help please
I must admit that even after a few years, while I mostly understand my thyroid test results, my iron tests continue to confuse me - I just can’t seem to get my head around the significance of the different parts. So I wondered if someone who actually understands could please explain in really simple
I must admit that even after a few years, while I mostly understand my thyroid test results, my iron tests continue to confuse me - I just can’t seem to get my head around the significance of the different parts. So I wondered if someone who actually understands could please explain in really simple
Mazes
in
Thyroid UK
11 months ago
NDT Named Patient basis
Hello everyone. I'm just seeking an update: Is NDT still only prescribed on NHS on a named patient basis? I was listening to the interview of Lynn last year and there was talk this may no longer be required. Am thinking of moving GP surgeries as its barely functioning but don't want to jinx my NHS NDT
Hello everyone. I'm just seeking an update: Is NDT still only prescribed on NHS on a named patient basis? I was listening to the interview of Lynn last year and there was talk this may no longer be required. Am thinking of moving GP surgeries as its barely functioning but don't want to jinx my NHS NDT
waveylines
in
Thyroid UK
11 months ago
Did not get baseline testosterone level at start of my Eligard shots.
How important is getting a baseline testosterone level at the start of
ADT
? My
ADT
therapy may last 2.5 years. My second
ADT
shot and testosterone level test is Nov.3. Any comments would be greatly appreciated.
How important is getting a baseline testosterone level at the start of
ADT
? My
ADT
therapy may last 2.5 years. My second
ADT
shot and testosterone level test is Nov.3. Any comments would be greatly appreciated.
Danskor
in
Advanced Prostate Cancer
2 years ago
Just getting started
RO is suggesting 40 sessions of IMRT/IGRT and 2 years of
ADT
. Not advisable to use a spacer due to the location of the extracapsular extension of the lesion. Lymph nodes to be treated. Will use fiducials with the possibility of a Brachy boost.
RO is suggesting 40 sessions of IMRT/IGRT and 2 years of
ADT
. Not advisable to use a spacer due to the location of the extracapsular extension of the lesion. Lymph nodes to be treated. Will use fiducials with the possibility of a Brachy boost.
OldVTGuy
in
Advanced Prostate Cancer
2 years ago
Another vacation?
I changed MO's in order to try intermittent
ADT
, hence the third vacation.
I changed MO's in order to try intermittent
ADT
, hence the third vacation.
kainasar
in
Advanced Prostate Cancer
2 years ago
Metastatic Hormone-Sensitive Prostate Cancer: Is Docetaxel Really Needed? Researchers suggest simpler ADT+ASI as default therapy.
[/i] [i]
No clinical trials have compared
plus an ASI head-to-head with
ADT
and docetaxel in these patients.
[/i] [i]
No clinical trials have compared
plus an ASI head-to-head with
ADT
and docetaxel in these patients.
cujoe
in
Fight Prostate Cancer
2 years ago
Update #10: The Adrenal Gateway
Hello 👋 Following on from my previous update here: https://healthunlocked.com/thyroiduk/posts/149797821/9-thyroid-hormones-introduced-i-can-finally-tolerate-t3 I have had some bloods back. I also found I am clear for adrenal antibodies 🎉 so I don’t have Addison’s. In 2022 on 88 T4, 10 T3 [u][
Hello 👋 Following on from my previous update here: https://healthunlocked.com/thyroiduk/posts/149797821/9-thyroid-hormones-introduced-i-can-finally-tolerate-t3 I have had some bloods back. I also found I am clear for adrenal antibodies 🎉 so I don’t have Addison’s. In 2022 on 88 T4, 10 T3 [u][
Hidden
in
Thyroid UK
11 months ago
Curcumin (Theracurmin) Improves Mild Cognitive Impairment and Memory - A Randomized Clinical Trial
What we call "Chemo-Brain" is a form of MCI resulting from cancer treatments including chemotherapy and also
ADT
in some of us with APC. This includes myself so I am very interested in this result.
What we call "Chemo-Brain" is a form of MCI resulting from cancer treatments including chemotherapy and also
ADT
in some of us with APC. This includes myself so I am very interested in this result.
MateoBeach
in
Fight Prostate Cancer
1 year ago
MH Support
I am now off
ADT
, and testing every 6 months. Libido is returning, but my equipment has been through the wringer. I’m 60 and would some day like to somehow resume relations with spouse. This, plus the assumption of cancer returning at some point, has me down.
I am now off
ADT
, and testing every 6 months. Libido is returning, but my equipment has been through the wringer. I’m 60 and would some day like to somehow resume relations with spouse. This, plus the assumption of cancer returning at some point, has me down.
C-RI
in
Advanced Prostate Cancer
1 year ago
Sildenafil for ADT side effect?
My Medical Oncologist is a DO and thinks I may be on
ADT
for a total of 18 months. I may start 28 sessions of EBRT soon. I'm worried about penile atrophy. Would it be a good idea to ask my urologist for sildenafil to prevent penile atrophy?
My Medical Oncologist is a DO and thinks I may be on
ADT
for a total of 18 months. I may start 28 sessions of EBRT soon. I'm worried about penile atrophy. Would it be a good idea to ask my urologist for sildenafil to prevent penile atrophy?
Danskor
in
Advanced Prostate Cancer
2 years ago
PSA #’s elevated from sex (After ADT and RT)
I’ve been on Active Surveillance since completing my
ADT
and RT both in 2017 &18 finally coming out of castration in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
I’ve been on Active Surveillance since completing my
ADT
and RT both in 2017 &18 finally coming out of castration in 2019 / early 2020 with a basement T level, so I began Penile Rehab. Well over a year after that, I was able to resume (what I now refer to as) sexual relations with my wife!
Jimhoy
in
Prostate Cancer Network
2 years ago
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