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Experiences with
Androgen deprivation therapy (ADT)
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High-Dose Transdermal Estradiol as ADT
Does anyone have any experience with this? According to my understanding: It's not FDA approved, but used here in the U.S., and all over the rest of the world. It's at least as effective in lowering T to castrate levels. It carries a far more tolerable profile of SEs than LHRH drugs, presumably
Does anyone have any experience with this? According to my understanding: It's not FDA approved, but used here in the U.S., and all over the rest of the world. It's at least as effective in lowering T to castrate levels. It carries a far more tolerable profile of SEs than LHRH drugs, presumably
Horse12888
in
Advanced Prostate Cancer
6 months ago
Thanks and hope to all
Brachytherapy prior with
ADT
for the last 7 months. Things seem to be going as smoothly as it sometimes does.
Brachytherapy prior with
ADT
for the last 7 months. Things seem to be going as smoothly as it sometimes does.
Yokohama2023
in
Advanced Prostate Cancer
4 months ago
After bicalutimide and a high testosterone level is pre treatment T just guess work?
some input/advice/ thoughts as I make a decision on how far to push to the SOC for my high risk G9, given my oncologist is saying 15 months adjuvant (I am nervous of anything less than 18 months) is enough given my co morbidities, age at 73 , current low T at 0,6 (17) and PSA of 0.01 throughout the
ADT
some input/advice/ thoughts as I make a decision on how far to push to the SOC for my high risk G9, given my oncologist is saying 15 months adjuvant (I am nervous of anything less than 18 months) is enough given my co morbidities, age at 73 , current low T at 0,6 (17) and PSA of 0.01 throughout the
ADT
SimMartin
in
Prostate Cancer Network
4 months ago
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PSA post Salvage Radiation
He hasn’t been on
ADT
, is that the next step? He’s BRCA2 positive. We’ll also make an appointment with his oncologist . I appreciate any guidance/help on what we should ask/research as I’m quite new to this and, of course, worried. thank you!!
He hasn’t been on
ADT
, is that the next step? He’s BRCA2 positive. We’ll also make an appointment with his oncologist . I appreciate any guidance/help on what we should ask/research as I’m quite new to this and, of course, worried. thank you!!
Silverlings
in
Advanced Prostate Cancer
4 months ago
Agonists vs. antagonists (the latter not to be confused with a character in a novel!)
I know many of you on this site are beyond
ADT
, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx).
I know many of you on this site are beyond
ADT
, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx).
bluesnjazz
in
Advanced Prostate Cancer
3 months ago
It's Back!
Did 39 treatments off radiation and have been mostly on
ADT
for the duration except during COVID I took a break of 18 months or so. Went metastatic about 3 1/2 to 4 years ago and started Xtandi.
Did 39 treatments off radiation and have been mostly on
ADT
for the duration except during COVID I took a break of 18 months or so. Went metastatic about 3 1/2 to 4 years ago and started Xtandi.
Tjc1
in
Advanced Prostate Cancer
3 months ago
Survey!
So, I and other members can get an idea on how you feel about
vacation(s). Please just answer YES if you think they’re okay, or NO, if you think they’re not.
So, I and other members can get an idea on how you feel about
vacation(s). Please just answer YES if you think they’re okay, or NO, if you think they’re not.
j-o-h-n
in
Advanced Prostate Cancer
6 months ago
De-escalation
I am working with my own MO on de-escalation so no
ADT
injection for me at the end of September and so am on the Apalutamide monotherapy. ( only been a couple of weeks). Will report my QOL situation plus any change to. My PSA which has been undetectable for 14 months.
I am working with my own MO on de-escalation so no
ADT
injection for me at the end of September and so am on the Apalutamide monotherapy. ( only been a couple of weeks). Will report my QOL situation plus any change to. My PSA which has been undetectable for 14 months.
Brysonal
in
Fight Prostate Cancer
6 months ago
Second Opinion
I have been on
ADT
for 18 months. I started Eligard injections and Xtandi. However, I had a number of cardiac events including a mild heart attack and went off the Xtandi for 9 months.
I have been on
ADT
for 18 months. I started Eligard injections and Xtandi. However, I had a number of cardiac events including a mild heart attack and went off the Xtandi for 9 months.
jcarey79
in
Advanced Prostate Cancer
8 months ago
Long survivors with ADT + Xtandi (Enzulatamide)
I am advised to start
ADT
+ Xtandi. Who are longest still on this combination without getting castration resistant?
I am advised to start
ADT
+ Xtandi. Who are longest still on this combination without getting castration resistant?
ElemanJ
in
Advanced Prostate Cancer
9 months ago
Criteria for "my ADT has stopped working and we have to move to another"
Hello - So my third post
ADT
initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up.
Hello - So my third post
ADT
initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up.
jackwfrench
in
Advanced Prostate Cancer
4 months ago
Thoughts on Denosumab in my case
On monthly
ADT
injections, radiation starting soon. ——————- T score interpretation according to the National Osteoporosis Foundation: T-score at or above -1.0 Normal T-score between -1.0 and -2.5 osteopenia T-score at or below -2.5 osteoporosis REGION: L-spine (L1-4): BMD (g/cm2): 1.139 g/cm2
On monthly
ADT
injections, radiation starting soon. ——————- T score interpretation according to the National Osteoporosis Foundation: T-score at or above -1.0 Normal T-score between -1.0 and -2.5 osteopenia T-score at or below -2.5 osteoporosis REGION: L-spine (L1-4): BMD (g/cm2): 1.139 g/cm2
Hope49823
in
Advanced Prostate Cancer
2 months ago
Ten Months After All Treatments Ended
After the side effects of
ADT
wore off I started to feel better, even though my testosterone is still low. It’s not a vacation. I just reached the end of my 24 months of
ADT
. I hope and pray that both the testosterone and the PSA continue to remain at low levels.
After the side effects of
ADT
wore off I started to feel better, even though my testosterone is still low. It’s not a vacation. I just reached the end of my 24 months of
ADT
. I hope and pray that both the testosterone and the PSA continue to remain at low levels.
TottenhamMan
in
Advanced Prostate Cancer
8 months ago
Hot Flashes and Veozah
I am 19 months into my 2 years on
ADT
+ Zytiga & P. 6 months into it, I started experiencing severe hot flashes. Severe = Full body sweats, dripping off my brow, palms wet and needing to mop it off my chest or change my shirt. Every 1 -2 hours. I tried 4 antidepressants that didn't work.
I am 19 months into my 2 years on
ADT
+ Zytiga & P. 6 months into it, I started experiencing severe hot flashes. Severe = Full body sweats, dripping off my brow, palms wet and needing to mop it off my chest or change my shirt. Every 1 -2 hours. I tried 4 antidepressants that didn't work.
Huzzah1
in
Advanced Prostate Cancer
3 months ago
Edema
Due to
ADT
, I have swelling of the stomach due to edema, i guess. Anybody have the same problem? Treatent I should go over with my doc? Also a bit of gynomastia. .
Due to
ADT
, I have swelling of the stomach due to edema, i guess. Anybody have the same problem? Treatent I should go over with my doc? Also a bit of gynomastia. .
gsun
in
Advanced Prostate Cancer
9 months ago
Urinary bother; is Flomax a solution?
SBRT plus
ADT
for 12 months after clean PSMA and 3+4, 4+3, and 4+4. Still up peeing 3 times a night after 4.5 months post radiation. (Down from 8 times). Does anyone know if Flomax will help? Or are there other solutions?
SBRT plus
ADT
for 12 months after clean PSMA and 3+4, 4+3, and 4+4. Still up peeing 3 times a night after 4.5 months post radiation. (Down from 8 times). Does anyone know if Flomax will help? Or are there other solutions?
Photographerhere
in
Prostate Cancer Network
7 months ago
EBRT - Is it the right thing and what to expect?
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of
ADT
of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84.
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of
ADT
of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84.
JazzMan42
in
Advanced Prostate Cancer
23 days ago
Shoud I be concerned with my PSA rising from .79 to 1.01 in about 10 months?
Diagnosed with prostate cancer in August'18 with PSA of 7.84, Greason score of 7 (4+3) before being treated with SBRT without
ADT
at UCLA in October'18. Reached nadir at .79 after 4.5 years after SBRT treatment.
Diagnosed with prostate cancer in August'18 with PSA of 7.84, Greason score of 7 (4+3) before being treated with SBRT without
ADT
at UCLA in October'18. Reached nadir at .79 after 4.5 years after SBRT treatment.
mike2344
in
Prostate Cancer Network
3 months ago
HDR boost Brachytherapy + IMRT
All RO’s I’ve met with want to wait 2-3 months for the
ADT
to do its thing and shrink the primary tumor and lymph nodes before they that radiation start treatment. One RO I met with wants to treat with just IMRT. Another I met with wants to use HDR Brachy boost + IMRT.
All RO’s I’ve met with want to wait 2-3 months for the
ADT
to do its thing and shrink the primary tumor and lymph nodes before they that radiation start treatment. One RO I met with wants to treat with just IMRT. Another I met with wants to use HDR Brachy boost + IMRT.
Cenerus
in
Advanced Prostate Cancer
28 days ago
Time to PSA Nadir is related to progression-free-survival
Cohort:
ADT
monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points very well, with a high correlation coefficient, R^2 = 0.944, and a low p = 0.040.
Cohort:
ADT
monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points very well, with a high correlation coefficient, R^2 = 0.944, and a low p = 0.040.
janebob99
in
Advanced Prostate Cancer
1 month ago
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