Long survivors with ADT + Xtandi (Enzulatamide)

[ElemanJ]

5 years after RPE and RT my PSA is rising again. I am advised to start ADT + Xtandi. Who are longest still on this combination without getting castration resistant?

[RyderLake2]

Hello,

I was five years on Xtandi (enzalutamide) before switching to Zytiga (abiraterone) plus Prednisone as part of a clinical trial. My PSA continues to be quite low so I am not castrate resistant yet.

[ElemanJ in reply to RyderLake2]

With or withou ADT (Lupron or similar)?

[RyderLake2 in reply to ElemanJ]

Hello,

Except for one year when I was on Firmagon (degarelix) I remained taking Zoladex (goserelin acetate) while I was on Xtandi. I am still on Zoladex injections, ten years and three months since diagnosis at the end of May, 2013. Hope that helps!

[John-carp]

Hey

I am seven years on intermittent ADT. Currently I am three years into my 2nd vacation and undetectable and monitor carefully - so for me it feels like a lot of options out there to keep the beast in check.

[chaplainj in reply to John-carp]

What is your intermittent protocol consist of. Thanks and wish you a nice evening. Blessings! Chaplain J

[ElemanJ in reply to chaplainj]

Currently I am not on medication.

[John-carp in reply to chaplainj]

Hey. I am currently on three years since last treatment. Watch Psa carefully and if it moves to detectable I will get scans etc. this vacation was following treatments after a previous vacation where PSA increased got a scan radiation on the creatures and ADP. Make sense

[kainasar in reply to John-carp]

Im no expert but recc to everyone to get a PSMA scan after this much treatment. Scan uncovers the sleeping monster.

[ElemanJ in reply to kainasar]

Did one allready. Unfortunately my tumor (metastasis) has no PSMA expression at PSA 1,5 ng/ml.

[larry_dammit]

good morning. I’ve been on this treatment now since I finished chemo in 12/16. Almost 7 years on xtandi Psa is 0.05 and has stayed there since finishing chemo. Hope this helps. Good luck warrior 🙏🙏

[ElemanJ in reply to larry_dammit]

Are you on Xtandi alone or Xtandi + ADT?

[larry_dammit in reply to ElemanJ]

Xtandi plus eligard and exgiva

[lcfcpolo]

Just passed 3 years on Xtandi and ADT. Good luck.

[Magnus1964]

Everyone responds differently to medications. I was on Casodex for 5 years, zytiga for 3.5 years, and xtandi for 4 years.

[kainasar in reply to Magnus1964]

May I ask - abirat and enzalutamide + ADT? what kind? thanks.

[Magnus1964 in reply to kainasar]

Casodex is bicalutimide

Zytiga is aboraterone

Xtandi is enzalutamide

[alephnull]

I was never offered Xtandi until PCa went CR. They wouldn't even consider Xtandi until I reached that milestone.

17 months in, and I'm undetectable, but feel like carp!

Tired all the time and my cognition is certainly down dramatically.

[Justfor_ in reply to alephnull]

Have you tried lowering dosage to the minimum effective one instead of the maximum tolerable. User "Stoneartist" is doing that.

[Hidden in reply to alephnull]

Could you switch to Darolutamide? Does not penetrate the Blood Brain Barrier, side effects much lighter than with Enza

[larry_dammit]

I’ve been on ADT And Xtandi now for almost 8 years, Mets all over. PSA after chemo. 0.05