De-escalation

[Brysonal]

So I am following the de-escalation trials as discussed here:

dailynews.ascopubs.org/do/c....

I am working with my own MO on de-escalation so no ADT injection for me at the end of September and so am on the Apalutamide monotherapy. ( only been a couple of weeks).

Will report my QOL situation plus any change to. My PSA which has been undetectable for 14 months.

Anyone on these trials as I would be interested to hear.

Regards all

[KocoPr]

Lol! Im confused is it de escation, se escalation, or deescalarion?

You should take it easy on the liquid meds brother.😜

[Brysonal in reply to KocoPr]

Lol...I've amended my dodgy spelling!

[Brysonal]

I was looking for a bit more info on Arm A of Libertas trial as it seems a bit vague

Clinical trial extract

[Lizzo30]

You may benefit from researching the health benefits of melatonin for heart health and prostate cancer

[Justfor_]

De-escalation is a polite way of saying: "stop the silliness of throwing around kitchen sinks". Intermittent anti-androgen treatment, like the Libertas trial, is better than fixed standard dosage, but lacking behind proportional dosage adjustment. OP is aware of my Bicalutamide maneuvers, but persuading his MO isn't a trivial thing.

[NPfisherman]

Brysonal,

Good luck on de-escalation plans...

Fish

[NPfisherman]

I am in my own n=1 de-escalation plan doing IADT and then vacationing...

Based on the article, I am an excellent candidate based on my PSA scores...

Bonne chance, mon ami

Fish