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Abiraterone
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Bone scan. Thoughts?
We are planning on going straight into another form of therapy (probably
abiraterone
) along with continued ADT. Would it be worthwhile to pursue a bone biopsy to see what those lesions really are? If cancer, could he potentially get radiation there?
We are planning on going straight into another form of therapy (probably
abiraterone
) along with continued ADT. Would it be worthwhile to pursue a bone biopsy to see what those lesions really are? If cancer, could he potentially get radiation there?
mediocra
in
Advanced Prostate Cancer
5 years ago
Glucocorticoids & Bone demineralization.
"Results from the ERA 223 trial of
abiraterone
combined with radium-223 among men with chemotherapy-naïve castration-resistant prostate cancer and bone metastases show no improvement in survival free from symptomatic skeletal events.
"Results from the ERA 223 trial of
abiraterone
combined with radium-223 among men with chemotherapy-naïve castration-resistant prostate cancer and bone metastases show no improvement in survival free from symptomatic skeletal events.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Addition of Metformin after Progression on Abiraterone.
Metformin was added to
abiraterone
continuously at 1000 mg twice daily in uninterrupted 4-week cycles.
Metformin was added to
abiraterone
continuously at 1000 mg twice daily in uninterrupted 4-week cycles.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
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Calling all PC nerds: Facts/opinions/views on Zytiga (Abiraterone) metabolism?
Some background: Zytiga itself is
abiraterone
acetate, the salt form of
abiraterone
that is more readily absorbed than pure
abiraterone
and resistant to premature metabolism.
Some background: Zytiga itself is
abiraterone
acetate, the salt form of
abiraterone
that is more readily absorbed than pure
abiraterone
and resistant to premature metabolism.
SeosamhM
in
Advanced Prostate Cancer
5 years ago
Treatment failure
Cabazitaxel and
Abiraterone
has made him so weak he can’t eat at all for 2 weeks and he has weight loss ,His oncologist said disappointing things and I all I can do is crying
Cabazitaxel and
Abiraterone
has made him so weak he can’t eat at all for 2 weeks and he has weight loss ,His oncologist said disappointing things and I all I can do is crying
Annie1373
in
Advanced Prostate Cancer
5 years ago
We should admit it
I think it’s end of our journey,Dad diagnosised on May13th with metastasis.Nothing worked on him Docetaxcel,
Abiraterone
and cabazitaxel ...Now he states that he has pain his chest ...I think there’s no hope ..We should admit it
I think it’s end of our journey,Dad diagnosised on May13th with metastasis.Nothing worked on him Docetaxcel,
Abiraterone
and cabazitaxel ...Now he states that he has pain his chest ...I think there’s no hope ..We should admit it
Annie1373
in
Advanced Prostate Cancer
5 years ago
Darolutamide
The percentages of patients who received subsequent treatment are lower than those reported in the SPARTAN trial, in which the trial design included the provision of
abiraterone
for patients in whom metastases developed.
The percentages of patients who received subsequent treatment are lower than those reported in the SPARTAN trial, in which the trial design included the provision of
abiraterone
for patients in whom metastases developed.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Thoughts on BAT
So far, most trials have involved patients who had failed ADT 1 (Zolodex, Lupron) and the second order antiandrogens like Enzalutamide and
Abiraterone
. So they were in the context of evident resistance against Abi and Enza shown by rising PSA (and I think shortening doubling times).
So far, most trials have involved patients who had failed ADT 1 (Zolodex, Lupron) and the second order antiandrogens like Enzalutamide and
Abiraterone
. So they were in the context of evident resistance against Abi and Enza shown by rising PSA (and I think shortening doubling times).
kaptank
in
Advanced Prostate Cancer
5 years ago
Abiraterone/Zytiga at beginning of treatment for oligometastatic cancer, but with CVD
We were given the possibility to begin with firmagon + Zytiga from beginning of treatment (plus radiation to prostate, pelvis + mets), Gleason 9 T3b N1 M1, PSA 28. Because of atherosclerosis (70% blockage) not sure of adding Zytiga now, also if research shows advantage. In addition I have the impression
We were given the possibility to begin with firmagon + Zytiga from beginning of treatment (plus radiation to prostate, pelvis + mets), Gleason 9 T3b N1 M1, PSA 28. Because of atherosclerosis (70% blockage) not sure of adding Zytiga now, also if research shows advantage. In addition I have the impression
Hidden
in
Advanced Prostate Cancer
5 years ago
Treatment plan
I mentioned Brachytherapy but he said more dose would go to the prostate which would mean less to lymph nodes and
Abiraterone
has same results as chemo but would have to be paid for out of pocket. What do you think?
I mentioned Brachytherapy but he said more dose would go to the prostate which would mean less to lymph nodes and
Abiraterone
has same results as chemo but would have to be paid for out of pocket. What do you think?
Fdccs
in
Advanced Prostate Cancer
5 years ago
Cardiac arrhythmia considerations of hormone cancer therapies.
In prostate cancer, androgen deprivation therapy is associated with long QT and Torsade de pointes, and possibly atrial fibrillation for
abiraterone
. In this review, we have summarized the clinical and preclinical data focusing on cardiac arrhythmia considerations of hormone cancer therapies."
In prostate cancer, androgen deprivation therapy is associated with long QT and Torsade de pointes, and possibly atrial fibrillation for
abiraterone
. In this review, we have summarized the clinical and preclinical data focusing on cardiac arrhythmia considerations of hormone cancer therapies."
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Generic Zytiga - abiraterone acetate price
A little over a month ago, the specialty pharmacy services that dispensed Zytiga offered a generic option. I went ahead and accept it. Just received a billing statement from my Medicare supplement (AARP United Healthcare) and they show a 30% price drop for this generic. Got me to thinking, should I shop
A little over a month ago, the specialty pharmacy services that dispensed Zytiga offered a generic option. I went ahead and accept it. Just received a billing statement from my Medicare supplement (AARP United Healthcare) and they show a 30% price drop for this generic. Got me to thinking, should I shop
Cmdrdata
in
Advanced Prostate Cancer
6 years ago
Phase 3 ARCHES trial - Enzalutamide + ADT
It made me uneasy, since
Abiraterone
is a form of ADT, and the androgen receptor antagonists, such as Casodex & Enzalutamide can be viewed as forms of ADT. In fact, I was pulled up on it, as others also view these drugs as ADT elements. Anyway, here again, ADT is being used in its old sense.}
It made me uneasy, since
Abiraterone
is a form of ADT, and the androgen receptor antagonists, such as Casodex & Enzalutamide can be viewed as forms of ADT. In fact, I was pulled up on it, as others also view these drugs as ADT elements. Anyway, here again, ADT is being used in its old sense.}
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Starting a new drug "Abiraterone"
He is starting me on "
Abiraterone
". Anyone have input on side effects? Kip & Molly
He is starting me on "
Abiraterone
". Anyone have input on side effects? Kip & Molly
Hidden
in
Advanced Prostate Cancer
6 years ago
My Journey so far since diagnosis of prostate cancer
In the meantime I am in a fair bit of discomfort and have been put on
abiraterone
which I hope will be effective to last until March.
In the meantime I am in a fair bit of discomfort and have been put on
abiraterone
which I hope will be effective to last until March.
Muirk1960
in
Advanced Prostate Cancer
6 years ago
ERLEADA® (apalutamide) - TITAN Study.
Abiraterone
plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer. New England Journal of Medicine. June 2017. 4 ClinicalTrials.gov. A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC (TITAN).
Abiraterone
plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer. New England Journal of Medicine. June 2017. 4 ClinicalTrials.gov. A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC (TITAN).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
"Novel Hormonal Therapies" Before and After Chemotherapy
KEYWORDS: Gleason score;
abiraterone
; age; enzalutamide; orteronel PMID: 30620216 DOI: 10.1089/cbr.2018.2702
KEYWORDS: Gleason score;
abiraterone
; age; enzalutamide; orteronel PMID: 30620216 DOI: 10.1089/cbr.2018.2702
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Metastasis-Free Survival in Prostate Cancer: Faster Drug Approvals, Better Drugs?
But the landscape of metastatic prostate cancer changed in 2011, when
abiraterone
acetate (with prednisone) became the first second-generation antiandrogen approved to treat metastatic CRPC, demonstrating a 4-month survival benefit over placebo in the second line of treatment.
But the landscape of metastatic prostate cancer changed in 2011, when
abiraterone
acetate (with prednisone) became the first second-generation antiandrogen approved to treat metastatic CRPC, demonstrating a 4-month survival benefit over placebo in the second line of treatment.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Niraparib - The GALAHAD study (NCT02854436).
Besides GALAHAD, Janssen is also conducting the MAGNITUDE Phase 3 trial (NCT03748641), testing Zejula in combination with Zytiga (
abiraterone
acetate) and prednisone in adults with metastatic prostate cancer.
Besides GALAHAD, Janssen is also conducting the MAGNITUDE Phase 3 trial (NCT03748641), testing Zejula in combination with Zytiga (
abiraterone
acetate) and prednisone in adults with metastatic prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
New to this, but have followed for a year
Anderson where I have endured Lupron. 6 rounds of Taxotere, and now I am on this cynical trial https://www.mdanderson.org/patients-family/diagnosis-treatment/clinical-trials/clinical-trials-index/clinical-trials-detail.ID2014-0386.html This trial to designed to see if two already approved drugs (
Abiraterone
Anderson where I have endured Lupron. 6 rounds of Taxotere, and now I am on this cynical trial https://www.mdanderson.org/patients-family/diagnosis-treatment/clinical-trials/clinical-trials-index/clinical-trials-detail.ID2014-0386.html This trial to designed to see if two already approved drugs (
Abiraterone
Raylin
in
Advanced Prostate Cancer
5 years ago
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