combination drug Olaparib and Abiraterone

[Iloveyoudad]

Hello. Has anybody undergone or undergoing a combination drug of Olaparib 150 mg 2 tabs 2x a day, Abiraterone Acetate 500mg 2 tabs a day, and Prednisone 5mg 1 tab 2x a day?

[dudubaya]

Yes, my dad who is BRCA2 +ve was given the same combination till Olaparib was effective. I think this is due to some recent study which shows synergestic effect between olaparib and abiraterone

[speranza10 in reply to dudubaya]

That's right, this study is called PROPEL and it has given good results even in BRCA negative patients

[WisdomSeeking]

Hello,

what is current PSA of your dad, what about his lung mets, ...? Please update the bio of your dad - last update is from end of 2023.

Is abiraterone still working?

[Ztlf]

My husband has been on abiraterone and 5 mg prednisone (plus eligarde injections every three months). He had a brief (20 sessions) very localized radiation treatment as well in October. He has done well so far--but they did start him on 10 mg of prednisone, which seemed to cause hypotension. He is planning to go on a brief break from the abiraterone. His PSA is now undetectable (from 53 in Jan. 2023). He was diagnosed with metastatic PC in January 2023 through a PSMA Pet Scan. His Gleason score was 3/3 in October 2023. He was diagnosed at 79 and has some other conditions, which has made the doctors be quite cautious, I believe.

[mrssnappy]

My husband added Olaparib to Abi and Prednisone in March 2024 when Abi started to fail. You can check profile for details on his journey. So far so good.