I have been taking methotrexate for 11 weeks for skin morphea, but have developed a collection of possible side effects: cramp, night sweats, eyes watering with tears running down my cheeks, very heavy sleeping but wake tired, vertigo, bubbling sound in one ear, a bit deaf, hoarse voice, big muscles in bottom and back of thighs aching. But the worst is swollen abdomen, or bloating - it feels tight and looks pregnant, and I put on 7 lbs in three week. A bit of problem weeing as well - going oftener and producing less. None of these are listed for methotrexate!
The situation is complicated by (A) stopping my thyroid treatment (levothyroxine 25 and 50 alternate days), (B) cutting my HRT in half (0.625 Premarin instead of 1.3), and (C) finishing a course of prednisolone, which started at the same time as the methotrexate.
My feeling is that the metho is the problem, and I've now stopped it. Not sure it was really doing any good anyway. I had got up to 10 mg once a week. It took two days out of my life every week, with feeling spaced out and sleepy and unable to do anything. I think I could have UVA treatment instead - can anyone say if that has helped them?
My doctor is sending me for an ultrasound scan. It can't be ovarian cancer since they were taken out in a total hysterectomy 35 years ago. I'm now 74.