I have been on Enhertu for over a year but my last two infusions are causing longer periods of nausea and fatigue .It was only for two days after the pre meds wore off.This time it has been a full week.Anyone else notice this?
I wonder if my Enhertu has run it's course because that was what I experienced when first diagnosed with metastatic breast cancer.
I felt sick to my stomach and didn't feel like eating 🤪
Hey there,
I'm sorry you feel poorly.
I know for me that when a treatment starts to fail, the side effects, especially the digestive side effects, get worse. Also, my doc calls me "heavily treated" so the combined toxicity of everything can be a factor.
I just started Enhertu this week and the pre-meds are finally wearing off so I can try to ascertain what this is going to be like and hopefully "buy" a year out of this med.
I'm chewing peppermint gum right now to stop my nausea.
My doctor gave me Ondansentron for nausea but it doesn't really seem to help much
I'm in the same position as you. I've been on Enhertu for over a year. I had a break for a couple of months due to worsening side effects and whilst I recovering from an op on my foot. I'm now having it every 4 weeks instead of 3 to give my body time to recover between cycles.
Thirteen months is the average progression free time on this drug. I don't feel like I've progressed (scans in next two weeks). I've been told it's long term toxicity and I'm not surprised. I've had almost constant chemotherapy and 3 rounds of stereotactic radiotherapy to my brain. during the last 6 years. Add to that all the scans with contrast and it's a wonder the build up of toxicity didn't appear sooner!
My question to the oncologist when I get to speak to her is "will I be able to tolerate another drug/s ?"
That sounds like the pre meds. Anti sickness tablets and steroids
No this was a new trial with Enhertu plus a first in human PARP inhibitor pill taken daily for seven days
She was in the Boston area
Her post was three days ago -- entitled "Starting a new trial - PETRA," and her username is garlic grower. She was taking PARP for 7 days -- after infusion of Enhertu, I think? Anyway, scroll down. Her post is there.
Thanks
So I am curious how you are doing now. I hope you are feeling better.
I just finished 4th round and met with NP. She says that side effects, especially digestive and exhaustion DO get worse. This med is probably not working for me - my CA-15 is inching up - not doubling like when previous meds have failed - but we are going to do one more round December 3 before my vacation and scans when I return. It sucks because I don't have a lot of options left. I do not like this med, I am almost always nauseous - I'm taking a lot of Pantaprozole for stomach acid to keep from vomiting during week 2. I'm simply not interested in sleeping my life away. I am ok with side effects when drug is working but....I will wait and see what the scans show and try to enjoy my vaca in December. It's the best I can do.
Thanks for letting me vent on your post.
I am doing quite well on Enhertu.No progression whatsoever and some evidence of improvement.The days after my infusion pre-drugs wear off my Oncologist has given me steroids pills for the fatigue and two different anti-nausea drugs to alternate on those days.I am so sorry you don't seem to tolerate this drug 😩. Hopefully your December3 round will prove to be better. Maybe ask for steroids to keep you from sleeping so much,?
This is the best treatment I have had and hope it keeps working for me(I have been on it for about 13 months).
Prayers for your body to feel more able to tolerate and become comfortable with your treatment 👍❤️
Thanks for responding. I will inquire as to your suggestions. Have an awesome day
First scan after Enhertu
Day 2 Enhertu infusion 
Enhertu side effect: pneumonitis (lung inflammation)
