Longer side effects after Enhertu infusion

[Figletf]

I have been on Enhertu for over a year but my last two infusions are causing longer periods of nausea and fatigue .It was only for two days after the pre meds wore off.This time it has been a full week.Anyone else notice this?

I wonder if my Enhertu has run it's course because that was what I experienced when first diagnosed with metastatic breast cancer.

I felt sick to my stomach and didn't feel like eating 🤪

[Iwasborntodothis]

Hey there,

I'm sorry you feel poorly.

I know for me that when a treatment starts to fail, the side effects, especially the digestive side effects, get worse. Also, my doc calls me "heavily treated" so the combined toxicity of everything can be a factor.

I just started Enhertu this week and the pre-meds are finally wearing off so I can try to ascertain what this is going to be like and hopefully "buy" a year out of this med.

I'm chewing peppermint gum right now to stop my nausea.

[Figletf in reply to Iwasborntodothis]

My doctor gave me Ondansentron for nausea but it doesn't really seem to help much

[Andersl in reply to Figletf]

I've been given cyclyzine along with ondansetron. I take one and if it doesn't work I take the other as well.

[Andersl]

I'm in the same position as you. I've been on Enhertu for over a year. I had a break for a couple of months due to worsening side effects and whilst I recovering from an op on my foot. I'm now having it every 4 weeks instead of 3 to give my body time to recover between cycles.

Thirteen months is the average progression free time on this drug. I don't feel like I've progressed (scans in next two weeks). I've been told it's long term toxicity and I'm not surprised. I've had almost constant chemotherapy and 3 rounds of stereotactic radiotherapy to my brain. during the last 6 years. Add to that all the scans with contrast and it's a wonder the build up of toxicity didn't appear sooner!

My question to the oncologist when I get to speak to her is "will I be able to tolerate another drug/s ?"

[Figletf in reply to Andersl]

Thanks for your input😊I hear people say on here that they are given 7 pills along with their Enhertu treatments.I have no idea what that is for ?

[Andersl]

That sounds like the pre meds. Anti sickness tablets and steroids

[Figletf in reply to Andersl]

No this was a new trial with Enhertu plus a first in human PARP inhibitor pill taken daily for seven days

She was in the Boston area

[TammyCross in reply to Figletf]

Her post was three days ago -- entitled "Starting a new trial - PETRA," and her username is garlic grower. She was taking PARP for 7 days -- after infusion of Enhertu, I think? Anyway, scroll down. Her post is there.

[Figletf in reply to TammyCross]

Thanks