Verzenio alone

[DinNorCal]

I was wondering if anyone has used Verzenio after Ibrance and Fulvestrant have failed? I did get a couple good years on the Ibrance/Fulvestrant

I am ER+ HR- and have used all my hormone treatment options and am facing IV Chemo. However my Dr. says Verzenio may be an option.

‘Thanks for any encouraging insights.

[Pbsoup]

I am on a revisit of CDK4/6 (Kisqali after Ibrance several years ago). Just started and it is intended as a place holder so we'll see. Let me know how it goes with you. I had a scan yesterday and the results aren't great, so he might tell me this isn't the time to experiment. We'll see. I so want to avoid IV. I think what is next is Enhertu. I just started Kisqali so hopefully can give it a bit of time to see...

Sorry--I realize this isn't exactly encouraging. I snooped around when we decided on Kisqali and have seen women who get quite a few months on a CDK4/6 revisit. My sense is one doesn't get the several years that can happen when it's a first line therapy. But it can kick the IV can down the road...

Where are you treated?

[DinNorCal in reply to Pbsoup]

Pbsoup

Thanks for your reply. I appreciate the input.

I live in Northern California and am in the UCDavis health system. I really like my oncologist.

We have to just keep pushing forward. I’m so resistant to IV Chemo but know it’s coming. So frustrated thinking about hair loss, as I feel on this chemo treatments I will never get hair back once it’s gone, because I’ll be on chemo for the rest of my life. Not like your on chemo for a few months then your done with it.

Thanks for listening 💕

[Pbsoup in reply to DinNorCal]

The hair thing is real! Plus I do t want all the side effects. I ride horses and really don’t want to give up.

Keep be in the loop on how it goes!

P

[TammyCross in reply to DinNorCal]

Someone I knew had to go on IV chemo pretty quickly since other meds didn't work. It did a good job for a few years so she went on a maintenance dose and her hair came back. Fuzz, but no longer bald.

[NShaft]

Have you had a recent liquid biopsy? There are new meds for the ESR1 and PIKA3 (?) mutations. I am on Orserdu for ESR1 and it is pretty easy.

[Salmon4 in reply to NShaft]

Hi Nshaft

I just started Orserdu. How long have you been on Orserdu? And have you had any side effects? I think this is my last choice before IV chemo

Thanks

[NShaft in reply to Salmon4]

I’ve been on it since March 2023. Very few side effects. Fatigue is the worst for me.

[TammyCross]

I went on Verzenio + letrozole/anastrozole after Ibeance and fulvestrant. I had a great run on the latter, NEAD. On Verzenio. I got a year of stable. Not as good but something. I don't know about Verzenio alone. It is generally harder than the other targeted therapies. My 2nd opinion dic ar MSK said she would have tried Kisqali next. It is more effective and has fewer side effects. I did try that next, nothing, but I was probably ESR1÷by then.I would hope you can try Kisqali instead of Verzenio.

For all of you afraid of IV chemo, I am now on Xeloda, oral chemo. You don't lose your hair. Supposed to be good for a couple of years. I don't know yet if it is working for me. Signs are not good. If not, Orserdu.

[DinNorCal]

Tammy, I was on Xeloda for about 9 months, it was very tolerable. then moved to Orsurdu (the latest treatment). Orserdu did not help me. Thus next trying the Verzenio.

We just keep fighting and praying for new discovery of treatments.

[Aprilfoolz1]

 DinNorCal and  Pbsoup and all, I know a woman on another MBC discussion board who did well on Ibrance / fulvestrant for 5 years . Had progression and switched to Affinitor /Aromosin and then xeloda . She is currently doing GREAT on a clinical trial , which is a cdk 4/6, a cdk 2 and fulvestrant. So, this is her second time on a cdk4/6 (but with the cdk 2 added ) . Trial is currently recruiting at UCSF .

Trial number is NCT04606446 , she refers to it as a Kat6 / CDK 4/6 trial and I believe it is a Pfizer trial .

[DinNorCal in reply to Aprilfoolz1]

Thank you Aprilfoolz1, I will do some research on that 👍

[Aprilfoolz1 in reply to DinNorCal]

I know Davis isn't super close to SF but I'm really happy this trial is going well , more options for us in the near future (I hope ).

[Pbsoup in reply to Aprilfoolz1]

thank you! I will ask my doctor about it.