Following up on a genomics report (47 pages ! Plus 54 min consult) and came across this study (phase 2 basket trial) in the US.
Essentially when exhausting, or before, standard of care options, allows patients to trial off label approved drugs using genomics to identify specific targetable variations, mutations.
Having said that they also trialed solid tumour treatments eg Pembrolizumab in patients with MBC with HTMB,
pubmed.ncbi.nim.nih.gov/338...
Genomics test called guardant360 in the US? ( blood or tissue)
Not universal benefit but for advanced, Metatastic cancers.
In the US insurance driven industry more emphasis on optimum treatment (cost?) ie targeted, precision therapies. Surgeons advocate from 2019.
The not so good in US? Big pharma, free enterprise, price gouging.
The fastest growth of personal debt in US.
ihi.org/insights/crisis-med...
In AU, UK ? Canada? is not socialised but more a safety net for those less well off, by definition private insurance spreads cost amongst a pool. Under huge pressure post Covid but still functioning.
In Canada?, UK, ? Australia, not standard of care but some clinicians can have it done in the public system.
We paid $3300 but now we have an onc part public and has contacts.
If having a biopsy, tissue the more robust.
old-prod.asco.org/research-...
Expensive protocol for non US citizens.🤨
Fortunately Australia has a similar but smaller scale, MoST program.
Australia has highest cancer rate in the world but one of the best survival rates.
Can anyone explain why advanced countries like Australia, New Zealand, Ireland, US have the highest rates but Sudan, South Sudan, Djibouti, Timor Leste have the lowest? (source: Dana - Faber)
Intermittent fasting, ketogenic diet? Metabolic theory, Warburg effect? Sugar? (Blood glucose more likely) . Curcumin? Natural fresh food?
Over 40% lifestyle, diet cancer risk factor but what the government don’t feature is the toxic environment we are exposed to in every day life.
Treatments incorporating metabolic theory are proving alusive but some evidence enhancing chemo, radiation ie traditional .
PET scans show the uptake of glucose by cancer cells, a possible avenue of further research.
Metformin, a diabetic treatment drug, has shown to reduce the risk of most cancers, some more than others. Pub Med - The relationship between Metformin consumption and cancer risk.
Immunology is the other new frontier showing promise , CAR T cell therapy proving effective in autoimmune diseases showing promise in some cancer treatments included with chemo.
I am liking the cancer pod, The moss report, Dr Li, Blaylock, integrative medicine.
On second tier, Fulvestrant. Oral SERD can’t come soon enough. 🙏🏻
Public system only funds CDK4/6 initially ie Ibrance yet it is the AI, Arimadex that invariably fails and combination therapy could be continued with say Verzenio, Fulvestrant as informed by genomics.
An analysis suggested CDK4/6 could be held in reserve thus saving money.
A new concept is not to wait for progression but mix it up, low dose oral chemo etc.
Not likely to be supported in the traditional cookie cutter standard of care Oncologist cohort.
Do no harm has frightened many, the best interests of the patient is my preference.
I personally want every evidence based rabbit hole explored for my dear partner.
Side effects 🤬
Has anyone used, know of infra red sauna?
The guru’s claiming special insight with a book, subscription deal stay clear of.
Bless.
Upcoming mastectomy and genomics
piqray
Experience and advice on treatment options with and without Ibrance.
