SKIN METS | VINORELBINE (Navelbine)

[matisse29]

Hi there

My skin mets have progressed and I’m now off 18 months of hormone therapies and back onto chemo, this time on oral Vinorelbine, which I am due to start in a few days’ time. Would appreciate any experiences with this drug. And treatment or skin mets.

I was diagnosed with metastatic breast cancer in Mar 2018 on discovering two tiny nodules on skin of chest wall - treated with capecitabine (Xeloda) first for six months. Bad side effects initially, though I fared better when they dropped the dosage after 2 cycles but it wasn’t effective. I then fared better with Tamoxifen for up to a year but progression in Nov 2019 to skin, rib/bone and pleura. Moved onto Exemestane, Denusomab injections and Pleurx. Latest CT shows stable disease except for what I pointed out to Onc a fortnight ago with visibly new skin nodules and lesions on chest was which seem to have progressed markedly in last few weeks (and causing a lot of discomfort in a few places - rash/inflammation). So now, we’re going for Vinorelbine. Nervous about side effects follow Cape experience!

[Barbteeth]

Hi there

I’ve just looked up this drug and the side effects are similar to everolimus which I’ve been taking for almost six months...like you I read the side effects and was scared to death...however apart from anaemia I’ve actually felt reasonably ok so I just wanted to tell you this

You may be absolutely fine...any drug change is scary...it’s the unknown

Good luck with it

Barb xx

[matisse29]

Thank you, Barb! That’s reassuring to hear. Glad you’ve been pretty much ok on everolimus. (though anaemia not so good). Hope positive effects continue for you! Nicki

[Bubbles001]

I had skin mets on my chest a year ago. Did you have a biopsy? Mine were triple negative even though my liver is 99% ER positive. I was treated in a clinical trial w Lynparza and Tecentriq, an immunotherapy. They cleared up and have not come back. The liver tumors are still there. You might ask about a biopsy and immunotherapy if your current treatment doesn’t work.

[matisse29 in reply to Bubbles001]

Thanks, Bubbles. I start on 14 May. Fingers. Tossed!

[SeattleMom]

Dear Matisse,

From what I’ve read, Vinorelbine is used to treat non small cell lung cancer. Why is this being prescribed for your MBC?

God bless you!

🙏🏻🙏🏻💗💗 Linda

[matisse29 in reply to SeattleMom]

HI LInda - it's also prescribed for breast cancer. And available as an oral chemo as well as IV.

I'll get the meds on Wednesday. Fingers crossed!

[SeattleMom in reply to matisse29]

You are in my thoughts and prayers!! God bless you!!

(Sorry my research was in error.)

XXOO Linda

[matisse29]

Thank you, Sandra! Appreciate this. Sorry it’s taken so long to respond. I start on 14 May. Fingers crossed!