I am new to this as I was diagnosed Stage 4 from the start with mets to my liver and bones. I switched treatment centers and my oncologist to Mayo in Rochester. I was previously just on Herceptin every three weeks with really no side effects. Mayo is starting me on Herceptin and Perjeta every three weeks and Taxol every week. I am ER, PR and HER2 positive. I just turned 50 and was premenopausal yet so I am receiving the Zoladex shot to put me in menopause. I have been reading that Taxol has some side effects that can be difficult for some, diarrhea and neuropathy. Please share your experiences with this combo and suggestions to help with the side effects, food that helps, supplements that I can take that will help that I can run through my oncologist.