Just following up on a recent post recommending magnesium malate for RLS, quoting recommendations made by Californian company Pure Biogenics in promoting their RLS supplement Seratame.
Looking into this, experiments on rats suggested that malate may be the most bio-available form of magnesium; there have also been studies showing good results treating fibromyalgia with a combination of magnesium and malic acid (although another study has not repeated these findings).
Checking further, I discovered that Seratame is now being promoted with the same claims made for magnesium glycinate - a salt which many forum members (particularly those in the US) will already be familiar with.
On querying the reformulation with Pure Biogenics they advised that during Covid there was a worldwide shortage of Mg malate so they had switched to Mg glycinate.
I did ask the company to give details of studies supporting their initial decision to formulate with Mg malate (specifically), but they've failed to respond. I also asked them why another heavily promoted ingredient in Seratame was probiotic Lactobacillus acidophilus and why this was changed to L. plantarum, but again no reply.
I have no views on the effectiveness of either formulation of Seratame, not having tried it.
I personally have had success with Mg citrate, this being more readily available OTC in the UK than Mg glycinate.
Magnesium supplement for RLS
RLS / BID / Magnesium
Magnesium and RLS
RLS Absence and Clarification
Magnesium and dopamine
