Magnesium salts and RLS: malate, glyc... - Restless Legs Syn...

Restless Legs Syndrome

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Magnesium salts and RLS: malate, glycinate or citrate

ChrisColumbus profile image
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Just following up on a recent post recommending magnesium malate for RLS, quoting recommendations made by Californian company Pure Biogenics in promoting their RLS supplement Seratame.

Looking into this, experiments on rats suggested that malate may be the most bio-available form of magnesium; there have also been studies showing good results treating fibromyalgia with a combination of magnesium and malic acid (although another study has not repeated these findings).

Checking further, I discovered that Seratame is now being promoted with the same claims made for magnesium glycinate - a salt which many forum members (particularly those in the US) will already be familiar with.

On querying the reformulation with Pure Biogenics they advised that during Covid there was a worldwide shortage of Mg malate so they had switched to Mg glycinate.

I did ask the company to give details of studies supporting their initial decision to formulate with Mg malate (specifically), but they've failed to respond. I also asked them why another heavily promoted ingredient in Seratame was probiotic Lactobacillus acidophilus and why this was changed to L. plantarum, but again no reply.

I have no views on the effectiveness of either formulation of Seratame, not having tried it.

I personally have had success with Mg citrate, this being more readily available OTC in the UK than Mg glycinate.

healthunlocked.com/rlsuk/po...

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ChrisColumbus
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ChrisColumbus profile image
ChrisColumbus

Just for info, looking back, there have been a couple of Posts about Seratame on here: 3 years ago from someone saying that it helped them, and 4 years ago from someone asking whether anyone had tried it. There were no Replies to either Post.

GuillaumeL profile image
GuillaumeL

Seems like conventional promotional material from a supplement company. From your research, they seem to be trying to develop a niche product discourse: "this type of magnesium works better than this other type of magnesium!"

On a side note, basing ambitious health claims on a single rat study is a classic health grifter tactic.

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