After suffering with 24/7 all over the body RLS for 25 years, I found a Movement Disorder Clinic in Denver, Colorado. Took 5 months to get an appointment but has been SO worth it! I literally had no quality of life. I had seen many neurologists over the years, was prescribed Mirapex, requip to max dosage, 4mg Neupro patch which all eventually made me so much worse. Dr. Rajeev Kumar at the Rocky Mountain Movement Disorder Center assesed me and said I was in the top 1% of people who suffer from RLS. He initially prescribed gabapentin (up to 1,800mg), which didn't work, then on to Horizant, then Lyrica to no avail. All the while I was still on the 4mg Neupro patch. The goal was to find a drug that worked then wean me off the patch, which was making me worse. After trying all the different drugs he finally prescribed Methadone 5mg twice daily. I have relief for the first time in 25 years, AND I have been able to wean off the Neupro Patch! Dr. Kumar has said that it's unlikely I will experience augmentation with the methadone but he's not ruling it out because my case is so severe. If needed, he will refer me to a pain management clinic for further treatment, I'm thrilled and I am mostly symptom free and feeling great!!