HI all. I suffered from RLS before doctors were even familiar with the term. I had heard about restless legs syndrome on TV and wanted to try the new drug (Requip) they were advertising to help people suffering with the symptoms mentioned. I found a Dr. who had heard of it and prescribed it for me, starting at the lowest dose and working up to a maximum allowed of 4 mg a day. I have been on Requip (ropinirole) for 20 years and it has been a God-send for me. Mirapex (pramipexole) is another good one! Both the generics and brand names are drugs called dopamine agonists and although fantastic for a lot of people, they are not for everyone because there are side effects with every drug. Again, I consider myself very lucky to have found one that has worked successfully for 20 years.
Opioids are also very effective, but extremely hard to get from a Dr. given our society's current drug addiction rate. I had them along with ropinirole while I was in the hospital stuck in bed not moving, a situation in which my RLS should have been its worst but it wasn't and I contribute that to the opioids. There is no other explanation.