Hi Can anyone tell me of their experience with Targinact. As I am having to take higher doses of Tramadol (take four over an evening) and I am constipated most of the time I thought I might ask my G.P. for Targinact. If I come off Tramadol onto the new meds would I get withdrawal symptoms? Be grateful for any advice. I also take Temazepam at night before I go to bed.