I found this article because I noticed my husbands salivary secretions are still quite heavy using the newly prescribed drug, Atropine .... I discovered Glycopyrrolate's efficacy as compared to Atropine and will go back to the original prescription in 4 hours (though Atropine has a half life of 2 hours)
Another article noted that half of the Atropine taken is "lost " in the urine.....and as noted only has a half life of 2 hours.....My husband probably slobbered a 1/2 liter worth yesterday!
Praise the Lord he's sloberin' at all
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J R Soc Med. 1980 Oct; 73(10): 727–730.
Comparison of the effects of atropine and glycopyrrolate on various end-organs1
R K Mirakhur and J W Dundee
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Atropine and glycopyrrolate (glycopyrronium bromide), a quaternary ammonium drug, were evaluated in volunteers following intramuscular administration with respect to effects on various end-organs with cholinergic innervation. Glycopyrrolate appears to be five to six times more potent than atropine in its antisialogogue effect and also exhibits a selective, though prolonged, effect on salivary secretion and sweat gland activity. It has minimal cardiovascular, ocular and central nervous system effects.
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