Metformin - 1,000mg time release - started this for pre-diabetes, it didn't seem to keep cancer from recurring OR maybe it kept the cancer from coming back worse - Metformin in cancer prevention and therapy
Fenbendazole - 3x4gm weekly - Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways | Scientific Reports
Loratidine - 10mg nightly - switched from cetirizine for hay fever when I read about its anti-cancer potential - Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment
IP6 & Inositol - 1,600mg twice daily - Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis- II. Effects on integrins and focal adhesions. - PubMed - NCBI
DIM - 300mg once daily - Multiple therapeutic and preventive effects of 3,3′-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia
Artemisinin - 200mg daily - Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
Sodium Butyrate - 600mg daily - Sodium Butyrate Induces Growth Inhibition and Apoptosis in Human Prostate Cancer DU145 Cells by Up-Regulation of the Expression of Annexin A1
I think that's all. There are more studies than these, didn't want to list them all. Whether these substances actually work or not...who knows? At least there's some science behind them. Whether it's good science or not...who knows? But I thought I'd throw everything I can find at the cancer, see if something sticks. I'd throw the kitchen sink at it if I thought it might work. If any of these actually do work - well, I'm taking so many that I'll never know which one(s). Don't care really. My PSA was going up, been going down since I started the fenben. Next PSA coming up this week. I'm hoping for the best.
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kapakahi
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I have no idea if your supplement regimen is helping you or not, but I understand your desire to try everything. Having a disease like cancer makes you feel that your future is out of your hands and we all desire to do something to fight it, even if there's no well proven thing to do.
According to the articles I've read, exercise and good diet are also helpful in combating the cancer.
Specifically, I've only recently become aware of literature re: metformin and cancer. Something re: metformin and lung cancer just crossed my desk yesterday. More generally there is this:
Good luck to you. I am also on several meds and supplements in the hope of slowing things down. Please keep us posted on how you are going. We need some hopeful stories. I'm taking mebendazole but may swop to Fenbendazole soon as it seems to block more pathways.
Many many people are doing what you are doing and getting some success with various cancer types. I wish you every success.
I would recommend you increase the IP6 dose. Your dose is too light to fight prostate cancer cells in my experience. You seem to be taking two capsules in the AM & PM. They must be taken by themselves on an empty stomach (two hours no food or meds). Please switch to the powder version of your capsule manufacturer. Take two full scoops Am and again in the PM. (I personally take a much larger dose.)
Have you read AKM Shamsuddin's 2011 text on "IP6 & Inositol"? It is outstanding.
Never forget Dr. Shamsuddin's advice: IP6 is a dose-dependent medication. The heavier the dose, the better the results.
I also highly recommend reading the published articles of Dr. Rajesh Agarwal of the University of Colorado School of Health Sciences - Denver. He is known for his work on prostate cancer and Shamsuddin recommends his work.
You will find his work at pubmed.gov and there is a youtube video where he talks about the specific results of a prostate cancer study and the identified pathway IP6 affects.
I'm taking a total of 3200 mg per day - is that enough? Half in the morning on an empty stomach, half in the evening - 8 pills 400mg each - unfortunately, sometimes my evening dose comes within 2 hours of eating, but if I get up in the middle of the night to take some I'll never get back to sleep, and it also means I have to disconnect my CPAP. I thought of trying the powder, haven't yet. Haven't read Shamsuddin's article.
My personal opinion is that 3.2 g is insufficient. I have a Gleason eight cancer cell. When I was taking the equivalent of 48 capsules throughout the day it wasn’t enough. It had to increase another 50% to gain traction and reduce my PSA. I know that may sound like a staggering dose.
The first time I had a visit with my urologist after going to a heavy dose he was taken aback by the PSA number. He insisted I have a DRE ( my prostate had not been removed because I was stage 4). I had not told him I was taking IP six. When palpating my prostate he said in a surprised tone you don’t have any nodules. I told him that was a good thing wasn’t it? He mumbled something. I told him six months later. After moving to Florida I found a new urologist. He read my medical chart and the part about no nodules on the prostate. He acted very skeptical and insisted on his doing a DRE. After completing the most thorough exam I’ve ever experienced, he said there are no nodules!
Think hard about your schedule. It’s important to keep IP six away from any protein molecules. The IP six molecules will bind to the proteins and become ineffective.
Good luck with these. If I were in your position, I would try anything and everything that has the slightest chance of defeating cancer. I have been fortunate with my two (unrelated) cancers (so far), both having been found and treated (by surgery) at Stage I and II respectively. The main thing is, you are working at it and not giving up. Best wishes.
Latest PSA 9/16/19: 1.996. That's a 33% increase in one month - not yet scary, but it's probably more than a typical anomaly in PSA (my PSAs are low compared to what most guys here have experienced because 1) no mets and 2) my prostate was hemi-ablated 4 years ago by HIFU, so I have only half a gland left). This is a reversal of what I hoped was a trend downward as fenben kills the cancer. It coincides with my adding 4 more anti-cancer supplements to the regimen in the last couple of weeks: IP-6, DIM, artemisinin, and sodium butyrate. So in case they're interfering with fenben, I guess I'll cut those out and continue with just the fenben for another month - this time daily instead of 3 days on/4 days off - and once again hope for the best.
Update: the latest PSA dropped back down to 1.5 - so it's really bouncing around for unknown reasons (11/18 0.9; 4/19 1.8; 5/19 2.27; 6/19 1.8; 7/19 1.5; 9/19 1.99; 10/19 1.5). I stopped the IP-6, DIM, artemisinin, and sodium butyrate - I'm not as sure about their cancer-fighting abilities as I am about fenben (and I'm not convinced about fenben yet but think the possibilities for it are higher than the others), thought maybe they could interfere with fenben, they were getting expensive, and I was having problems swallowing so many pills.
After reading Tall Allen's comments about vitamin E - my multi has 400mg of the d-alpha kind implicated in cancer - I halved the multi (it's pretty high in most vitamins so half is more than enough) and also added the gamma version of E, which I read works against cancer and also may reduce the amount of d-alpha in blood and tissues. Unfortunately, the capsule also contains a small amount of d-alpha (33mg), so all I can do is hope that the gamma counteracts the d-alpha. It also has 500mg of "mixed" tocopherols in it (without saying what the mix is), and I don't know how those react with cancer, though the linked article below does credit delta-E with some anti-cancer properties. cancerpreventionresearch.aa...
As others here have noted, there's a study suggesting that fenben plus d-alpha E causes apoptosis in prostate cancer cells. This study in 2011 saying alpha E good was followed in 2012 by the study above saying alpha E bad. But you have to read the fine print: the 2011 researchers confess that "Statistical analysis was performed with [Microsoft] excel 2007." Seriously? Excel 2007? Well, there ya go - so much for that study's legitimacy! [From Wikipedia: "The accuracy and convenience of statistical tools in Excel has been criticized as mishandling missing data, as returning incorrect values due to inept handling of round-off and large numbers, as only selectively updating calculations on a spreadsheet when some cell values are changed, and as having a limited set of statistical tools."]
Meanwhile, I've made the ground-breaking discovery that woodworking is associated with prostate cancer! How, you may ask? I'm a beginning woodworker - well, I'd call it woodwrecker right now, and in a fit of frustration at finding 1/8" at one end of a table leg is mysteriously different than 1/8" at the other end (multiplied by all the different measurements I take daily), 3 days ago I made the most delicious chocolate chip cookies I've ever made (just guessing at measurements) and have been pigging out on them since after months of behaving myself and controlling my sugar intake. Well, since cancer cells take up more sugar than normal cells, the other change I've made in my regimen is to raise my metformin intake from 1g to 2g daily (time release), one morning and one evening. So that's how woodworking is associated with prostate cancer.
I know, I know, the news media will glom onto this discovery and change "associated with" to "causes" and I'll have to change my phone number to avoid all the calls for comment and advice. I guess my advice would be to take up fingerpainting instead of woodworking, and be sure the paint you use has no VOCs.
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Where I'm at so far....
Rising PSA after RP June 2018
My RO Wants Me to Do_ADT, HDR & EBRT
How to determine what is a normal PSA after radiation therapy?
