Actemra and chest discomfort

[91066Jackson]

Tomorrow will be my third injection of Actemra as I attempt to taper from 40 mg daily down to 30 mg daily. I have more headaches than usual but nothing I can’t live with. But for the last two weeks I’ve had what feels like a big gas bubble in my chest and through to my back (right side). Anyone else experience this? Any comments? Thanks in advance for your responses.

[PMRpro Ambassador]

Have you spoken to your GP or - even better - your rheumy nurse helpline? You should have a contact number when you are on a biologic.

Have you had a blood test this week? You should be monitored quite closely at first - my first blood test is after 2 weeks.

[SheffieldJane]

As chest infections are one of the common side effects of Actemra, I would certainly tell your doctor about this symptom. They used to routinely give you a chest X-Ray before prescribing this drug. I think, for TB. This might be a good idea. The “ bubble” is an odd symptom to report. I wonder if it is anything to do with your oesophageal area? I found that I was experiencing symptoms in my upper digestive system. I also routinely had a wheezy chest but no infection was diagnosed. I was X Rayed though.

[PMRpro Ambassador in reply to SheffieldJane]

Pancreatitis is a possible adverse effect.

[SheffieldJane in reply to PMRpro]

Yes but surely not after 2 doses?

[PMRpro Ambassador in reply to SheffieldJane]

Difficult to say isn't it - it is mainly associated with long term use, you are right. But a PMR friend had a gastric bleed after 3 doses of ibuprofen ordered by her GP for PMR. any GI problems really do need to be reported - they may be nothing to do with the TCZ but an unconnected coincidental problem.

[91066Jackson in reply to SheffieldJane]

Didn’t know about the chest infection issue but I will pursue with my rheumy and/or GP and see where it goes. Thanks so much for responding, Jane.

[Sharitone]

I haven't had anything like that, but I hope you'll let us know how you get on.