There is occasional discussion about CBD oil and if it could modulate our illness. I came across this research article and it looks like it has a definite affect on IL2 not IL6.
A tough read but interesting.
ncbi.nlm.nih.gov/pmc/articl...
Enjoy.
CBD again🤔: There is occasional discussion about... - PMRGCAuk
CBD again🤔
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fmkkm
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PMRproAmbassador
Presumably parallels the fact that anti-TNF drugs don't work in PMR at least and are specifically warned against in the guidelines. Though I think there is some evidence that T-cells are involved in GCA in some patients - which is probably why Actemra doesn't work 100% in all patients.
That’s so interesting. Is it possible that the ones who Actemra does not work for have another form of vasculitis?
Unlikely, in that the patients in the clinical trials would have had confirmed GCA, most likely by TAB in which case the giant cells would have been seen. However, there is some evidence that there are different pathways producing cytokines, the inflammatory substances that are involved. Not sure how tocilizumab works except it interferes with the pathways producing IL-6. But there is more than one pathway.
Can you phrase this article in layman's terms please?
"Taken together, these data suggest that CBD suppresses T cell function and that CB1 and/or CB2 play a critical role in the magnitude of the in vitro anti-sRBC IgM AFC response."
"A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity. T cells can be distinguished from other lymphocytes, such as B cells and natural killer cells, by the presence of a T-cell receptor on the cell surface."
All drugs and hormones etc work by attaching to receptors on various cells. No receptor, no effect basically. The cannaboid receptors CB1 and CB2 don't have a high affinity for CBD but are crucial to how much effect there is.
It is just a study that investigated HOW CBD works: it suppresses the T-cells which are central to the immune response and in some way via particular receptors.
But more than that - would take me a week or so to read and get my head round it! Wrong pay grade 
Thanks so much for reviewing. I was always under the impression that GCA involved just macrophages. I just read another study that said both Tcell lymphocytes and macrophages. When these lymph cells go into a hyper immune state it involves IL-2. So maybe there is something to CBD benefiting GCA symptoms?
I have bee using CBD oil for about 3 months.It has really helped me .I take 11 mg before I go to sleep and I sleep through the night without pain.Than ,you wake up rested and don’t have the fatigue during the day.It has also helped me to taper .
I did a lot of research and you have to buy top quality that is 3rd party tested and doesn’t have additives.i use Extra strength hemp extract oil.
Olive oil flavor.
Hope this is a help.
Hi,
That sounds great. Even if it doesn’t directly affect the disease just getting good sleep is amazing. I would also think it’s affect on stress would help with flares.
Best/fm
• in reply toBaileyw06
That's very interesting. Can you advise as to the strength of the capsules and perhaps the company who supplied or made them? Healthspan in Guernsey supply cannabidiol (CBD) at a strength of 6.4mg and I believe other strengths.
Baileyw06• in reply to
I use Charlottes Web and it has no THC.I use the oil not the capsules. On the label it reads hemp co2,extract number of milligrams and aerial which is the way it is processed, which is the purest of forms, I use the extra strength.You really need to the research on the brand you buy because it is not regulated.I am in the states.They say you should start at the lower dose and than increase.
• in reply toBaileyw06
Thank you, I shall investigate because I have trouble sleeping due to another painful condition related to nerve pain. I was given amitriptyline but I don't like the side effects.
Kenneth77• in reply to
Took amitriptyline75mg for a few years for sleep. the sedative action was among the best, but the side effects were annoying to be kind. then Dalmane (flurazepam) worked great, but extremely habit forming in that you can't stop easily. I now use 50mg promethazine + 12.5mg of zolpidem.
• in reply toKenneth77
Thanks for the input and Interesting to say the least, i'm tempted to stick to insomnia, if it wasn't for the pain I would. I must look up promethazine and zolpidem but I would think that they were addictive like most things to help with sleep and pain. However I appear to be one of those people who can't tolerate a lot of medicines, for instance I thought I was dying when I tried gabapentin and statins were horrific.
Happy days.
HeronNS• in reply to
Calcium supplement has helped me, others use magnesium. Just a couple of capsules (about 300 mg calcium altogether) near bedtime with a small snack, in my case usually a large spoonful of plain full fat yoghurt. It wasn't able to completely override heavy duty stress connected to my renovations and move, but even so I only had one night when I gave up and got up, and the rest of the time I've had no trouble falling asleep and staying that way, although I do get up very early. Several years on still helps.
• in reply toHeronNS
Thanks I'll give it a go!
Baileyw06• in reply to
Hope it works for you
• in reply toBaileyw06
I don't know how that happened, I replied to you but somehow I replied to myself !
See the reply to myself. I'm probably still asleep 😉
• in reply to
I tried it last night. Well it did and it didn't 🤔 I went to bed at about 10.30 pm and fell asleep quite quickly. I woke at 1.30 am thinking it was time to get up. I did manage to get back to sleep fairly quickly and finally woke again and got up at 6.30 am. So their was some improvement. I shall give it a go for a few weeks so monitor the situation.
Baileyw06• in reply to
It might take a few days to work, you might try increasing the dose
Suet3942• in reply to
That is my sleep circle exactly.
• in reply toSuet3942
Oh really, but I must admit it's somewhat annoying 🤗
Suet3942• in reply to
You can say that again!
• in reply toSuet3942
Maybe we should form a club. We could call it 'The 1.30am Wide Awake Club' (TWAC) 
• in reply to
Troupe rather than club? Sorry i am such a child 😂
Sign me up. Been awake at 1.30am evety night but 1 in the past 3 weeks. Blaming everything on sleep deprivation.
• in reply to
Well we have to blame it on something, sleep deprivation is my excuse as well 🤗
• in reply to
Cbd doesn't come free of effects ...as usual...but its weighing quality of life vs side effects.
cbdoilreview.org/cbd-cannab...
I would Rather have tbe full version with THC ...hope they add the medicinal use to other chronic pain conditions. I certainly found it helped with my fibromyalgia despite the risks.
Baileyw06• in reply to
I was lucky,I haven’t had any side effects and it has helped my quality of life.
• in reply toBaileyw06
Its great to have the option. 🤞
Because of the way it effects the enzyme in tbe liver that metabolises other drugs that i take beyond pred, i am very nervous. One paper i read mentioned how it can make pred less or more efficient, same for other meds too. I have enough of a hard time balancing them now! If it helped me sleep i would love to have it. If i see a special deal.i will buy and try. That way if it does mess with my meds i wont feel bad throwing it away when i am on a limited budget.
Baileyw06• in reply to
Do you have a Lucky’s, that is where I got my Charlotte ‘s Web.They had a return policy that I could return it with the receipt if it didn’t work.
• in reply toBaileyw06
I cant find uk version. As you can see its 4am and i have been up for hours so if it worked cbd would be great. There is talk of banning it for 18mths to do clinical tests.
dailymail.co.uk/news/articl...
Baileyw06• in reply to
Sorry to hear that
• in reply toBaileyw06
I have diabetes and read tbe other day tbat it can help treat that so yku never know it may be on prescription eventually.
diabetes.co.uk/news/2015/Ap...
The Newcastle/Glasgow study seems to suggest that their supervised very low calorie diet can reverse Type 2 and insulin resistance.
• in reply toBaileyw06
Sorry as you can see i try to do my research before i try things! Whereas as a whippersnapper i tried things to see if i liked them😜😂
• in reply toBaileyw06
It is the daily mail though!
Is this what you have?
charlottesweb.com/extra-str...
No you either need the 11 mg extra strength and use 2 droppers or the 23mg extra strength and use 1 dropper
I buy what ever is on sale of those 2 and I like the olive oil the best
The brand is right
• in reply to
Thank you for that, I found it very informative and useful. Under the circumstances I won't try it.
powerwalk• in reply to
Did you have the medicinal version? That helped with the fibro?
Hello, ive been taking curcumin and Vit D for about 3 months, and I think it is helping - im on 10mg of Pred for my PMR, and just a little bit of morni ng stiffness which soon goes. Im going to stay on 10mg until back from my trail walk in early May, then attempt the slow taper to 9mg. Thanks to everyone for all the valuable info!
There was a programme on the other day about cbd and about diets to reverse diabetes. I taped it but havent had time to watch it yet.
Health: Truth or Scare, Series 3: Episode 1: bbc.co.uk/iplayer/episode/m... via @bbciplayer
Increased THC makes it more effective, if you can deal with the Euphoria, it's called the Entourage Effect. The anti inflammatory and pain easing properties of CBD and THC together are synergistically better. Here in Florida, they just legalized marijuana dispensaries to sell " Flower" or buds of the plant for smoking or vaping. For me and 3 years of PMR stuck now at 7.5 mgs/day, it helps as does the giddy side effect of getting stoned and dealing philosphically with our condition and lot in life. It brings peace to PTSD sfferers. I'm 65 and smoked the stuff in College in the 70's recreationally. One survey said today's Millenials prefer it over alcohol. This herbal plant from God's Green Earth is natural and safe, no one ever died from overdose excess. Whatever gets you through the night said John Lennon, a Pot, Weed, Cannabis Advocate.
• in reply tosalparadise127
Still "illegal" in the uk although i doubt one would end up in court for personal use. Still funds and is funded by organised crime most often. At least you can follow the provenance when its legalised. The only people you see smoking and vaping outdoors around are young kids....who are driving. I could stand in the street and get stoned sniffing the cars as they go past. The problem is that some of skunk and other high thc plants do seem to be causing psychological issues and psychosis as it is much more powerful since the 90s.
nhs.uk/news/mental-health/s...
I often thought the benefits i got for fibromyalgia were more of the not worrying about the pain anymore. I.e dealing philosphically with the illness.
I am not ready to try THC yet, as long as this is working
I’ve been taking CBD and turmeric for a few weeks. Couldn’t tolerate pred and needed something while waiting to see a rheumi.
Impact so far is:
Greatly reduced fatigue
Reduced pain - not taking painkillers most days
Better sleep
Rosacea and psoriasis also improving.
Sadly no real difference with range of movement in hips
Beyond me - any conclusions in everyday English that you can take out of the article and pass on?
I did, at the top of the thread.
sorry just realised that after I sent it x
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